Investigation of annexin A5 as a biomarker for Alzheimer's disease using neuronal cell culture and mouse model

• Published in: Journal of neuroscience research Vol. 88; no. 12; pp. 2682 - 2692
• Main Authors: Yamaguchi, Mami, Kokai, Yasuo, Imai, Shin-Ichi, Utsumi, Kumiko, Matsumoto, Kyoichi, Honda, Hirohito, Mizue, Yuka, Momma, Masako, Maeda, Tetsu, Toyomasu, Shozo, Ito, Yoichi M., Kobayashi, Seijyu, Hashimoto, Eri, Saito, Toshikazu, Sohma, Hitoshi
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.09.2010
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - blood; Alzheimer Disease - diagnosis; Alzheimer Disease - pathology; Alzheimer's disease; Amyloid beta-Protein Precursor - biosynthesis; Amyloid beta-Protein Precursor - genetics; Amyloid beta-Protein Precursor - physiology; Animals; annexin A5; Annexin A5 - biosynthesis; Annexin A5 - blood; biomarker; Biomarkers - blood; Ca2+ stress; Calcium Signaling - physiology; Cell Culture Techniques - methods; Cells, Cultured; Cerebral Cortex - metabolism; Cerebral Cortex - pathology; Disease Models, Animal; Female; Gene Expression Regulation - physiology; Homeostasis - genetics; Homeostasis - physiology; Humans; Male; Mice; Mice, Inbred ICR; Mice, Transgenic; Neurons - cytology; Neurons - metabolism; Neurons - pathology; Organ Specificity - genetics; Organ Specificity - physiology

Alzheimer's disease (AD) differs from other forms of dementia in its relation to amyloid β peptide (Aβ). Aβ, a proteolytic product of amyloid precursor proteins (APP), has a toxic effect on neuronal cells, which involves perturbation of their Ca2+ homeostasis. This effect implies that changes o...