Newt A1 cell-derived extracellular vesicles promote mammalian nerve growth

• Published in: Scientific reports Vol. 13; no. 1; pp. 11829 - 14
• Main Authors: Middleton, Ryan C., Liao, Ke, Liu, Weixin, de Couto, Geoff, Garcia, Nahuel, Antes, Travis, Wang, Yizhou, Wu, Di, Li, Xinling, Tourtellotte, Warren G., Marbán, Eduardo
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 22.07.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/378/368/2431; 631/378/87; 631/61/2300/1514; 631/80/86; 631/80/86/820; Animals; Axonogenesis; Cell differentiation; Cell interactions; Cell survival; Cells, Cultured; Embryogenesis; Embryonic growth stage; Extracellular Vesicles; Gene expression; Growth factors; Humanities and Social Sciences; Mammals; Microscopy; Mitogen-Activated Protein Kinase 7 - metabolism; multidisciplinary; Nerve growth factor; Nerve Growth Factor - metabolism; Neurites - metabolism; Neurons; Neurons - cytology; Neurons - metabolism; Ontology; Paracrine signalling; Rats; Science; Science (multidisciplinary); Signal Transduction; Stem cells; Superior cervical ganglion

Newts have the extraordinary ability to fully regenerate lost or damaged cardiac, neural and retinal tissues, and even amputated limbs. In contrast, mammals lack these broad regenerative capabilities. While the molecular basis of newts’ regenerative ability is the subject of active study, the underl...