MicroRNA-221 Regulates Hypertrophy of Ligamentum Flavum in Lumbar Spinal Stenosis by Targeting TIMP-2

• Published in: Spine (Philadelphia, Pa. 1976) Vol. 41; no. 4; p. 275
• Main Authors: Xu, Yun-qiang, Zhang, Zhen-hui, Zheng, Yong-fa, Feng, Shi-qing
• Format: Journal Article
• Language: English
• Published: United States 01.02.2016
• Subjects: Cells, Cultured; Down-Regulation; Gene Expression Profiling; Humans; Hypertrophy - metabolism; Ligamentum Flavum - metabolism; MicroRNAs - analysis; MicroRNAs - genetics; MicroRNAs - metabolism; Tissue Inhibitor of Metalloproteinase-2 - analysis; Tissue Inhibitor of Metalloproteinase-2 - metabolism

A study of lumbar ligamentum flavum (LF). The aim of this study was to identify LF hypertrophy related microRNAs (miRNAs) expression profile and to investigate the role of miRNAs in the development of LF hypertrophy in lumbar spinal stenosis (LSS). Although histologic and biologic literature on LF h...