Overview of major molecular alterations during progression from Barrett's esophagus to esophageal adenocarcinoma

• Published in: Annals of the New York Academy of Sciences Vol. 1381; no. 1; pp. 74 - 91
• Main Author: Kalatskaya, Irina
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.10.2016; Wiley Subscription Services, Inc
• Subjects: Accumulation; Adenocarcinoma; Adenocarcinoma - diagnosis; Adenocarcinoma - genetics; Adenocarcinoma - metabolism; Animals; Barrett Esophagus - diagnosis; Barrett Esophagus - genetics; Barrett Esophagus - metabolism; Barrett's esophagus; Biochemistry; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Cancer; cancer progression; Correlation; Cyclin-Dependent Kinase Inhibitor p18 - genetics; Cyclin-Dependent Kinase Inhibitor p18 - metabolism; Data mining; Disease Progression; Documents; Dysplasia; E-cadherin; Epithelium; esophageal adenocarcinoma; Esophageal cancer; Esophageal Neoplasms - diagnosis; Esophageal Neoplasms - genetics; Esophageal Neoplasms - metabolism; Esophagus; Extraction; Genes; Genetic transformation; genomic alterations; Health risk assessment; Health risks; Humans; Intestine; Membrane Proteins - genetics; Membrane Proteins - metabolism; NADPH Oxidase 5; NADPH Oxidases - genetics; NADPH Oxidases - metabolism; p53 Protein; Patients; Reactive Oxygen Species - metabolism; Risk factors; Transcription; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism; cancer progression; esophageal adenocarcinoma; genomic alterations; Barrett's esophagus

Esophageal adenocarcinoma (EAC) develops in the sequential transformation of normal epithelium into metaplastic epithelium, called Barrett's esophagus (BE), then to dysplasia, and finally cancer. BE is a common condition in which normal stratified squamous epithelium of the esophagus is replace...