Overview of major molecular alterations during progression from Barrett's esophagus to esophageal adenocarcinoma

Esophageal adenocarcinoma (EAC) develops in the sequential transformation of normal epithelium into metaplastic epithelium, called Barrett's esophagus (BE), then to dysplasia, and finally cancer. BE is a common condition in which normal stratified squamous epithelium of the esophagus is replace...

Full description

Saved in:
Bibliographic Details
Published inAnnals of the New York Academy of Sciences Vol. 1381; no. 1; pp. 74 - 91
Main Author Kalatskaya, Irina
Format Journal Article
LanguageEnglish
Published United States Blackwell Publishing Ltd 01.10.2016
Wiley Subscription Services, Inc
Subjects
Online AccessGet full text

Cover

Loading…
Abstract Esophageal adenocarcinoma (EAC) develops in the sequential transformation of normal epithelium into metaplastic epithelium, called Barrett's esophagus (BE), then to dysplasia, and finally cancer. BE is a common condition in which normal stratified squamous epithelium of the esophagus is replaced with an intestine‐like columnar epithelium, and it is the most prominent risk factor for EAC. This review aims to impartially systemize the knowledge from a large number of publications that describe the molecular and biochemical alterations occurring over this progression sequence. In order to provide an unbiased extraction of the knowledge from the literature, a text‐mining methodology was used to select genes that are involved in the BE progression, with the top candidate genes found to be TP53, CDKN2A, CTNNB1, CDH1, GPX3, and NOX5. In addition, sample frequencies across analyzed patient cohorts at each stage of disease progression are summarized. All six genes are altered in the majority of EAC patients, and accumulation of alterations correlates well with the sequential progression of BE to cancer, indicating that the text‐mining method is a valid approach for gene prioritization. This review discusses how, besides being cancer drivers, these genes are functionally interconnected and might collectively be considered a central hub of BE progression.
AbstractList Esophageal adenocarcinoma (EAC) develops in the sequential transformation of normal epithelium into metaplastic epithelium, called Barrett's esophagus (BE), then to dysplasia, and finally cancer. BE is a common condition in which normal stratified squamous epithelium of the esophagus is replaced with an intestine‐like columnar epithelium, and it is the most prominent risk factor for EAC. This review aims to impartially systemize the knowledge from a large number of publications that describe the molecular and biochemical alterations occurring over this progression sequence. In order to provide an unbiased extraction of the knowledge from the literature, a text‐mining methodology was used to select genes that are involved in the BE progression, with the top candidate genes found to be TP53 , CDKN2A , CTNNB1 , CDH1 , GPX3 , and NOX5 . In addition, sample frequencies across analyzed patient cohorts at each stage of disease progression are summarized. All six genes are altered in the majority of EAC patients, and accumulation of alterations correlates well with the sequential progression of BE to cancer, indicating that the text‐mining method is a valid approach for gene prioritization. This review discusses how, besides being cancer drivers, these genes are functionally interconnected and might collectively be considered a central hub of BE progression.
Esophageal adenocarcinoma (EAC) develops in the sequential transformation of normal epithelium into metaplastic epithelium, called Barrett's esophagus (BE), then to dysplasia, and finally cancer. BE is a common condition in which normal stratified squamous epithelium of the esophagus is replaced with an intestine-like columnar epithelium, and it is the most prominent risk factor for EAC. This review aims to impartially systemize the knowledge from a large number of publications that describe the molecular and biochemical alterations occurring over this progression sequence. In order to provide an unbiased extraction of the knowledge from the literature, a text-mining methodology was used to select genes that are involved in the BE progression, with the top candidate genes found to be TP53, CDKN2A, CTNNB1, CDH1, GPX3, and NOX5. In addition, sample frequencies across analyzed patient cohorts at each stage of disease progression are summarized. All six genes are altered in the majority of EAC patients, and accumulation of alterations correlates well with the sequential progression of BE to cancer, indicating that the text-mining method is a valid approach for gene prioritization. This review discusses how, besides being cancer drivers, these genes are functionally interconnected and might collectively be considered a central hub of BE progression.
Author Kalatskaya, Irina
Author_xml – sequence: 1
  givenname: Irina
  surname: Kalatskaya
  fullname: Kalatskaya, Irina
  email: irina.kalatskaya@oicr.on.ca, irina.kalatskaya@oicr.on.ca
  organization: Ontario Institute for Cancer Research, MaRS Centre, Ontario, Toronto, Canada
BackLink https://www.ncbi.nlm.nih.gov/pubmed/27415609$$D View this record in MEDLINE/PubMed
BookMark eNqNkU1v1DAQhi3Uim4XLvwAZIkDCCnFH0nGOZaKLbSr9gAIcbK8zmTJkthbO2nZf4-X7fbQQ4UPY3n0zKuxnmNy4LxDQl5xdsLT-eA2Jp5wyWX-jEw45FVWllIckAljAJmqhDwixzGuGONC5fCcHAnIeVGyakLW17cYblu8o76hvVn5QHvfoR07E6jpBgxmaL2LtB5D65Z0HfwyYIypR5vge_rRhIDD8DZSjH79yyzHSAe_f6DpqKnReWuCbZ3vzQty2Jgu4sv7e0q-zz59O_ucza_Pv5ydzjObVyLPFLNQL1gjsagWBZoytwujFENgNQhRSVYKq6QqOBMKjKxlbgWUoqhVIQol5JS82-WmjW9GjIPu22ix64xDP0bNlQQpOKj8P1BRAoeqYgl98whd-TG49BHNK5YiOQd4klIyiYJtmZL3O8oGH2PARq9D25uw0ZzprVi9Fav_iU3w6_vIcdFj_YDuTSaA74C7tsPNE1H66ufp131otptp44B_HmZM-K1LkFDoH1fnGuaXYnYhCj2TfwFROb2C
CODEN ANYAA9
CitedBy_id crossref_primary_10_18632_oncotarget_13391
crossref_primary_10_1016_j_heliyon_2024_e32271
crossref_primary_10_3390_medicines4030067
crossref_primary_10_1155_2019_2059516
crossref_primary_10_1016_j_giec_2016_12_002
crossref_primary_10_1111_his_14828
crossref_primary_10_3390_ijms221910301
crossref_primary_10_1016_j_advms_2018_04_002
crossref_primary_10_1016_j_bbcan_2019_05_003
crossref_primary_10_1016_j_hoc_2017_01_003
crossref_primary_10_1113_EP086204
crossref_primary_10_1002_mc_22708
crossref_primary_10_18632_oncotarget_16635
crossref_primary_10_3390_ijms24097817
crossref_primary_10_1038_s41598_022_09494_1
crossref_primary_10_3892_br_2018_1134
crossref_primary_10_34172_mejdd_2022_251
crossref_primary_10_1016_j_canlet_2018_09_017
crossref_primary_10_2174_1566524019666190405121139
Cites_doi 10.1001/jama.2011.513
10.1136/jcp.50.3.212
10.1038/35106593
10.1016/0925-4773(96)00597-7
10.1016/S0046-8177(99)90175-2
10.1038/bjc.1995.191
10.1002/bjs.18003815005
10.1038/ng.3343
10.1097/SLA.0000000000000424
10.1136/gut.2007.146290
10.1111/j.1572-0241.2001.04236.x
10.1136/bmjopen-2014-006640
10.1016/S0165-4608(98)00036-3
10.1101/gad.1971610
10.1007/s00428-004-1042-0
10.1016/S0002-9440(10)65570-8
10.1016/S0016-5085(98)70016-2
10.1038/366704a0
10.1159/000147748
10.18632/oncotarget.4512
10.1007/s00401-012-0958-8
10.1038/bjc.1995.34
10.1309/3QLC-5MF1-JYXU-A5XX
10.1038/ajg.2015.152
10.1126/science.1260419
10.1038/18884
10.1016/j.mrfmmm.2010.12.016
10.1126/science.275.5307.1787
10.1101/cshperspect.a003053
10.1016/j.canlet.2004.01.020
10.1177/0192623309356453
10.1152/ajpgi.00321.2013
10.1111/j.1442-2050.2004.00434.x
10.1101/cshperspect.a001008
10.3892/ijmm.2011.640
10.1007/s00464-015-4103-3
10.1038/sj.onc.1204902
10.1309/1DB6-GFVH-RA6W-Q07Y
10.1074/jbc.M700297200
10.1091/mbc.8.2.287
10.1242/jcs.115.13.2771
10.1242/jcs.00224
10.1158/0008-5472.CAN-04-1738
10.1152/ajpgi.00186.2010
10.1136/gutjnl-2013-305997
10.1007/s00418-014-1258-2
10.1038/labinvest.2008.67
10.1038/ng.2591
10.1136/gut.2005.083295
10.1093/carcin/bgu083
10.1158/2159-8290.CD-12-0189
10.1002/ijc.20212
10.1101/gad.511109
10.2174/15680096113136660102
10.1007/s00428-009-0769-z
10.1186/bcr309
10.1006/bbrc.2002.6591
10.1016/j.prp.2012.03.007
10.1136/gutjnl-2013-305372
10.1038/8991
10.1152/ajpcell.00080.2013
10.1002/path.1884
10.1093/jnci/92.22.1805
10.1016/0092-8674(95)90214-7
10.1593/neo.05328
10.1053/j.gastro.2005.08.053
10.1158/1055-9965.EPI-05-0246
10.1152/ajpgi.00064.2011
10.1002/(SICI)1097-0215(19970502)71:3<355::AID-IJC8>3.0.CO;2-X
10.1002/ijc.28016
10.1111/j.1442-2050.2009.00953.x
10.1093/nar/gkt441
10.1097/PAI.0b013e318168598b
10.3748/wjg.14.1044
10.1074/jbc.M603353200
10.1111/j.1442-2050.2007.00749.x
10.1016/0016-5085(94)90818-4
10.1093/hmg/ddp537
10.1136/jcp.2004.023721
10.1093/jnci/djr203
10.1053/gast.2002.33427
10.1001/archsurg.1997.01430310042007
10.1016/S0748-7983(98)80122-4
10.1038/sj.onc.1209338
10.1126/science.2144364
10.1002/path.4058
10.1309/L1Q3-E3AQ-APU9-NA0A
10.1016/j.ejca.2015.12.002
10.1093/jnci/95.10.750
10.1038/nrm1699
10.1186/s13000-016-0473-7
10.1158/0008-5472.CAN-09-2518
10.1016/S0021-9258(18)43889-6
10.1002/cncr.23419
10.1007/s12032-014-0250-y
10.1152/ajpgi.00291.2007
10.1101/cshperspect.a000919
10.1111/jgh.13289
10.1038/sj.bjc.6690577
10.3748/wjg.v16.i45.5669
10.1073/pnas.96.12.6937
10.1111/j.1582-4934.2008.00336.x
10.1016/0016-5085(93)91058-P
10.1053/gast.2002.32370
10.1371/journal.pone.0149735
10.1038/sj.bjc.6603744
10.1038/bjc.1998.44
10.1038/ng.3013
10.1242/jcs.112.8.1237
10.1111/j.1572-0241.2002.05444.x
10.1126/science.281.5382.1509
ContentType Journal Article
Copyright 2016 The Authors. published by Wiley Periodicals Inc. on behalf of The New York Academy of Sciences.
2016 New York Academy of Sciences.
2016 The New York Academy of Sciences
Copyright_xml – notice: 2016 The Authors. published by Wiley Periodicals Inc. on behalf of The New York Academy of Sciences.
– notice: 2016 New York Academy of Sciences.
– notice: 2016 The New York Academy of Sciences
DBID BSCLL
24P
WIN
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7QG
7QL
7QP
7QR
7ST
7T5
7T7
7TK
7TM
7TO
7U7
7U9
8FD
C1K
FR3
H94
K9.
M7N
P64
RC3
SOI
7X8
DOI 10.1111/nyas.13134
DatabaseName Istex
Open Access: Wiley-Blackwell Open Access Journals
Wiley Online Library
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
Animal Behavior Abstracts
Bacteriology Abstracts (Microbiology B)
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Environment Abstracts
Immunology Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
Neurosciences Abstracts
Nucleic Acids Abstracts
Oncogenes and Growth Factors Abstracts
Toxicology Abstracts
Virology and AIDS Abstracts
Technology Research Database
Environmental Sciences and Pollution Management
Engineering Research Database
AIDS and Cancer Research Abstracts
ProQuest Health & Medical Complete (Alumni)
Algology Mycology and Protozoology Abstracts (Microbiology C)
Biotechnology and BioEngineering Abstracts
Genetics Abstracts
Environment Abstracts
MEDLINE - Academic
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Virology and AIDS Abstracts
Oncogenes and Growth Factors Abstracts
Technology Research Database
Toxicology Abstracts
Nucleic Acids Abstracts
ProQuest Health & Medical Complete (Alumni)
Neurosciences Abstracts
Biotechnology and BioEngineering Abstracts
Environmental Sciences and Pollution Management
Genetics Abstracts
Animal Behavior Abstracts
Bacteriology Abstracts (Microbiology B)
Algology Mycology and Protozoology Abstracts (Microbiology C)
AIDS and Cancer Research Abstracts
Chemoreception Abstracts
Immunology Abstracts
Engineering Research Database
Industrial and Applied Microbiology Abstracts (Microbiology A)
Calcium & Calcified Tissue Abstracts
Environment Abstracts
MEDLINE - Academic
DatabaseTitleList CrossRef
MEDLINE - Academic
MEDLINE

Virology and AIDS Abstracts
Virology and AIDS Abstracts
AIDS and Cancer Research Abstracts
Database_xml – sequence: 1
  dbid: 24P
  name: Wiley_OA刊
  url: https://authorservices.wiley.com/open-science/open-access/browse-journals.html
  sourceTypes: Publisher
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Sciences (General)
Biology
EISSN 1749-6632
EndPage 91
ExternalDocumentID 4231152111
10_1111_nyas_13134
27415609
NYAS13134
ark_67375_WNG_7LK2FJ25_F
Genre article
Journal Article
Review
GroupedDBID ---
--Z
-~X
.3N
.55
.GA
.GJ
.Y3
05W
0R~
10A
1CY
1OB
1OC
23M
31~
33P
3O-
3SF
4.4
50Y
50Z
51W
51X
52M
52N
52O
52P
52S
52T
52U
52W
52X
53G
5GY
5HH
5LA
5RE
5VS
66C
692
6J9
702
79B
7PT
8-0
8-1
8-3
8-4
8-5
8UM
930
A03
AAESR
AAEVG
AAHHS
AAMDK
AANLZ
AAONW
AASGY
AAXRX
AAZKR
ABCQN
ABCUV
ABDBF
ABEML
ABJNI
ABLJU
ABPVW
ACAHQ
ACBWZ
ACCFJ
ACCZN
ACGFO
ACGFS
ACIWK
ACPOU
ACPRK
ACSCC
ACXBN
ACXQS
ADBBV
ADEOM
ADIZJ
ADKYN
ADMGS
ADOJD
ADOZA
ADXAS
ADZMN
ADZOD
AEEZP
AEGXH
AEIGN
AEIMD
AELAQ
AENEX
AEQDE
AEUQT
AEUYR
AFBPY
AFFNX
AFFPM
AFGKR
AFPWT
AFRAH
AFSWV
AFZJQ
AHBTC
AHEFC
AHMBA
AI.
AIAGR
AITYG
AIURR
AIWBW
AJBDE
AJXKR
ALAGY
ALMA_UNASSIGNED_HOLDINGS
ALUQN
AMBMR
AMYDB
ATUGU
AUFTA
AZBYB
AZFZN
AZVAB
BAFTC
BDRZF
BFHJK
BHBCM
BIYOS
BMNLL
BMXJE
BNHUX
BROTX
BRXPI
BSCLL
BY8
C45
CAG
CO8
COF
CS3
D-E
D-F
DC6
DCZOG
DPXWK
DR2
DRFUL
DRSTM
EBD
EBS
EJD
EMOBN
ESX
F00
F01
F04
F5P
FEDTE
FZ0
G-S
G.N
GODZA
H.T
H.X
HF~
HGLYW
HVGLF
HZI
HZ~
I-F
IH2
IX1
J0M
K48
L7B
LATKE
LC2
LC3
LEEKS
LH4
LITHE
LOXES
LP6
LP7
LUTES
LW6
LYRES
MEWTI
MK4
MRFUL
MRSTM
MSFUL
MSSTM
MXFUL
MXSTM
N04
N05
N9A
NF~
NHB
O66
O9-
OHT
OIG
OK1
OVD
P2P
P2W
P2X
P4D
PALCI
PQQKQ
Q.N
Q11
QB0
R.K
RAG
RIWAO
RJQFR
ROL
RX1
S10
SAMSI
SJN
SUPJJ
SV3
TEORI
TUS
UB1
UPT
V8K
VH1
W8V
W99
WBKPD
WH7
WHWMO
WIH
WIK
WOHZO
WQJ
WRC
WUP
WVDHM
WXSBR
X7M
XG1
YBU
YOC
YSK
ZGI
ZKB
ZXP
ZZTAW
~02
~IA
~KM
~WT
24P
WIN
CGR
CUY
CVF
ECM
EIF
NPM
AAMNL
AAYXX
ACRPL
ACYXJ
CITATION
7QG
7QL
7QP
7QR
7ST
7T5
7T7
7TK
7TM
7TO
7U7
7U9
8FD
C1K
FR3
H94
K9.
M7N
P64
RC3
SOI
7X8
ID FETCH-LOGICAL-c4924-80c7db0f3e59b5ea64cba880e70d72293062c838510287a3d34c27625d8525823
IEDL.DBID 24P
ISSN 0077-8923
IngestDate Wed Dec 04 01:54:10 EST 2024
Wed Dec 04 01:15:16 EST 2024
Tue Nov 19 04:36:29 EST 2024
Tue Nov 19 03:47:22 EST 2024
Fri Dec 06 02:56:32 EST 2024
Sat Sep 28 08:48:45 EDT 2024
Sat Aug 24 00:45:24 EDT 2024
Wed Oct 30 09:48:21 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords cancer progression
esophageal adenocarcinoma
genomic alterations
Barrett's esophagus
Language English
License Attribution-NonCommercial
2016 New York Academy of Sciences.
http://creativecommons.org/licenses/by-nc/4.0
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c4924-80c7db0f3e59b5ea64cba880e70d72293062c838510287a3d34c27625d8525823
Notes ArticleID:NYAS13134
istex:1B93144B29D9C8DE2038792C74E8C4EC9C85DF05
ark:/67375/WNG-7LK2FJ25-F
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ObjectType-Article-1
ObjectType-Feature-2
OpenAccessLink https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fnyas.13134
PMID 27415609
PQID 1833137331
PQPubID 946344
PageCount 18
ParticipantIDs proquest_miscellaneous_1837321784
proquest_miscellaneous_1826717990
proquest_journals_1908371177
proquest_journals_1833137331
crossref_primary_10_1111_nyas_13134
pubmed_primary_27415609
wiley_primary_10_1111_nyas_13134_NYAS13134
istex_primary_ark_67375_WNG_7LK2FJ25_F
PublicationCentury 2000
PublicationDate October 2016
PublicationDateYYYYMMDD 2016-10-01
PublicationDate_xml – month: 10
  year: 2016
  text: October 2016
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: New York
PublicationTitle Annals of the New York Academy of Sciences
PublicationTitleAlternate Ann. N.Y. Acad. Sci
PublicationYear 2016
Publisher Blackwell Publishing Ltd
Wiley Subscription Services, Inc
Publisher_xml – name: Blackwell Publishing Ltd
– name: Wiley Subscription Services, Inc
References Falkenback, D., M. Nilbert, S. Oberg & J. Johansson. 2008. Prognostic value of cell adhesion in esophageal adenocarcinomas. Dis. Esophagus 21: 97-102.
Murray, L., A. Sedo, M. Scott, et al. 2006. TP53 and progression from Barrett's metaplasia to oesophageal adenocarcinoma in a UK population cohort. Gut 55: 1390-1397.
Maley, C.C., P.C. Galipeau, X. Li, et al. 2004. The combination of genetic instability and clonal expansion predicts progression to esophageal adenocarcinoma. Cancer Res. 64: 7629-7633.
Bandla, S., J.H. Peters, D. Ruff, et al. 2014. Comparison of cancer-associated genetic abnormalities in columnar-lined esophagus tissues with and without goblet cells. Ann. Surg. 260: 72-80.
Peng, D.F., M. Razvi, H. Chen, et al. 2009. DNA hypermethylation regulates the expression of members of the Mu-class glutathione S-transferases and glutathione peroxidases in Barrett's adenocarcinoma. Gut 58: 5-15.
Wu, T.T., T. Watanabe, R. Heitmiller, et al. 1998. Genetic alterations in Barrett esophagus and adenocarcinomas of the esophagus and esophagogastric junction region. Am. J. Pathol. 153: 287-294.
Washington, K., A. Chiappori, K. Hamilton, et al. 1998. Expression of beta-catenin, alpha-catenin, and E-cadherin in Barrett's esophagus and esophageal adenocarcinomas. Mod. Pathol. 11: 805-813.
Bongiorno, P.F., M. al-Kasspooles, S.W. Lee, et al. 1995. E-cadherin expression in primary and metastatic thoracic neoplasms and in Barrett's oesophagus. Br. J. Cancer 71: 166-172.
Connell-Crowley, L., J.W. Harper & D.W. Goodrich. 1997. Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation. Mol. Biol. Cell 8: 287-301.
Quelle, D.E., F. Zindy, R.A. Ashmun & C.J. Sherr. 1995. Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell 83: 993-1000.
Kanai, Y., S. Ushijima, A.M. Hui, et al. 1997. The E-cadherin gene is silenced by CpG methylation in human hepatocellular carcinomas. Int. J. Cancer 71: 355-359.
He, T.C., A.B. Sparks, C. Rago, et al. 1998. Identification of c-MYC as a target of the APC pathway. Science 281: 1509-1512.
Berx, G. & F. Van Roy. 2001. The E-cadherin/catenin complex: an important gatekeeper in breast cancer tumorigenesis and malignant progression. Breast Cancer Res. 3: 289-293.
Wu, L., C. Timmers, B. Maiti, et al. 2001. The E2F1-3 transcription factors are essential for cellular proliferation. Nature 414: 457-462.
Si, J., J. Behar, J. Wands, et al. 2008. STAT5 mediates PAF-induced NADPH oxidase NOX5-S expression in Barrett's esophageal adenocarcinoma cells. Am. J. Physiol. Gastrointest. Liver Physiol. 294: G174-G183.
Björnstedt, M., J. Xue, W. Huang, et al. 1994. The thioredoxin and glutaredoxin systems are efficient electron donors to human plasma glutathione peroxidase. J. Biol. Chem. 269: 29382-29384.
Farhadi, A., J. Fields, A. Banan & A. Keshavarzian. 2002. Reactive oxygen species: are they involved in the pathogenesis of GERD, Barrett's esophagus, and the latter's progression toward esophageal cancer? Am. J. Gastroenterol. 97: 22-26.
Feith, M., H.J. Stein, J. Mueller & J.R. Siewert. 2004. Malignant degeneration of Barrett's esophagus: the role of the Ki-67 proliferation fraction, expression of E-cadherin and p53. Dis. Esophagus 17: 322-327.
Persons, D.L., W.S. Croughan, K.A. Borelli & R. Cherian. 1998. Interphase cytogenetics of esophageal adenocarcinoma and precursor lesions. Cancer Genet. Cytogenet. 106: 11-17.
Reid, B.J., L.J. Prevo, P.C. Galipeau, et al. 2001. Predictors of progression in Barrett's esophagus II: baseline 17p (p53) loss of heterozygosity identifies a patient subset at increased risk for neoplastic progression. Am. J. Gastroenterol. 96: 2839-2848.
Zhang, H.Y., K. Hormi-Carver, X. Zhang, et al. 2009. In benign Barrett's epithelial cells, acid exposure generates reactive oxygen species that cause DNA double-strand breaks. Cancer Res. 69: 9083-9089.
Sanz-Ortega, J., S. Hernández, M.C. Saez, et al. 2003. 3p21, 5q21, 9p21 and 17p13.1 allelic deletions are potential markers of individuals with a high risk of developing adenocarcinoma in Barrett's epithelium without dysplasia. Hepatogastroenterology 50: 404-407.
Clément, G., R. Braunschweig, N. Pasquier, et al. 2006. Alterations of the Wnt signaling pathway during the neoplastic progression of Barrett's esophagus. Oncogene 25: 3084-3092.
Wong, D.J., M.T. Barrett, R. Stöger, et al. 1997. P16INK4a promoter is hypermethylated at a high frequency in esophageal adenocarcinomas. Cancer Res. 57: 2619-2622.
Si, J., X. Fu, J. Behar, et al. 2007. NADPH oxidase NOX5-S mediates acid-induced cyclooxygenase-2 expression via activation of NF-κB in Barrett's esophageal adenocarcinoma cells. J. Biol. Chem. 282: 16244-16255.
Pinheiro, H., R. Bordeira-Carriço, S. Seixas, et al. 2010. Allele-specific CDH1 downregulation and hereditary diffuse gastric cancer. Hum. Mol. Genet. 19: 943-952.
Kawakami, K., J. Brabender, R.V. Lord, et al. 2000. Hypermethylated APC DNA in plasma and prognosis of patients with esophageal adenocarcinoma. J. Natl. Cancer Inst. 92: 1805-1811.
Zhuang, Z., A.O. Vortmeyer, E.J. Mark, et al. 1996. Barrett's esophagus: metaplastic cells with loss of heterozygosity at the APC gene locus are clonal precursors to invasive adenocarcinoma. Cancer Res. 56: 1961-1964.
Jankowski, J., P. Newham, O. Kandemir, et al. 1994. Differential expression of E-cadherin in normal, metaplastic and dysplastic esophageal mucosa-a putative biomarker. Int. J. Oncol. 4: 441-448.
James, C.D., J. He, V.P. Collins, et al. 1993. Localization of chromosome 9p homozygous deletions in glioma cell lines with markers constituting a continuous linkage group. Cancer Res. 53: 3674-3676.
Olivier, M., M. Hollstein & P. Hainaut. 2010. TP53 mutations in human cancers: origins, consequences, and clinical use. Cold Spring Harb. Perspect. Biol. 2: a001008.
Tannapfel, A., C. Busse, L. Weinans, et al. 2001. INK4a-ARF alterations and p53 mutations in hepatocellular carcinomas. Oncogene 20: 7104-7109.
Dulak, A.M., P. Stojanov, S. Peng, et al. 2013. Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity. Nat. Genet. 45: 478-486.
Wongsurawat, V.J., J.C. Finley, P.C. Galipeau, et al. 2006. Genetic mechanisms of TP53 loss of heterozygosity in Barrett's esophagus: implications for biomarker validation. Cancer Epidemiol. Biomarkers Prev. 15: 509-516.
Uhlén, M., L. Fagerberg, B.M. Hallström, et al. 2015. Proteomics. Tissue-based map of the human proteome. Science 347: 1260419.
Bian, Y.S., M.C. Osterheld, C. Fontolliet, et al. 2002. p16 Inactivation by methylation of the CDKN2A promoter occurs early during neoplastic progression in Barrett's esophagus. Gastroenterology 122: 1113-1121.
Tarmin, L., J. Yin, X. Zhou, et al. 1994. Frequent loss of heterozygosity on chromosome 9 in adenocarcinoma and squamous cell carcinoma of the esophagus. Cancer Res. 54: 6094-6096.
Binato, M., R.R. Gurski, R.B. Fagundes, et al. 2009. P53 and Ki-67 overexpression in gastroesophageal reflux disease-Barrett's esophagus and adenocarcinoma sequence. Dis. Esophagus 22: 588-595.
Klaunig, J.E., L.M. Kamendulis & B.A. Hocevar. 2010. Oxidative stress and oxidative damage in carcinogenesis. Toxicol. Pathol. 38: 96-109.
Tao, W. & A.J. Levine. 1999. P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of mdm2. Proc. Natl. Acad. Sci. U.S.A. 96: 6937-6941.
Fitzgerald, R.C., M. di Pietro, K. Ragunath, et al. 2014. British society of gastroenterology guidelines on the diagnosis and management of Barrett's oesophagus. Gut 63: 7-42.
Barrett, N.R. 1950. Chronic peptic ulcer of the oesophagus and 'oesophagitis.' Br. J. Surg. 38: 175-182.
Klump, B., C.J. Hsieh, K. Holzmann, et al. 1998. Hypermethylation of the CDKN2/p16 promoter during neoplastic progression in Barrett's esophagus. Gastroenterology 115: 1381-1386.
Parisi, T., A. Pollice, A. Di Cristofano, et al. 2002. Transcriptional regulation of the human tumor suppressor p14(ARF) by E2F1, E2F2, E2F3, and Sp1-like factors. Biochem. Biophys. Res. Commun. 291: 1138-1145.
González, M.V., M.L. Artímez, L. Rodrigo, et al. 1997. Mutation analysis of the p53, APC, and p16 genes in the Barrett's oesophagus, dysplasia, and adenocarcinoma. J. Clin. Pathol. 50: 212-217.
Hong, J., M. Resnick, J. Behar, et al. 2010. Acid-induced p16 hypermethylation contributes to development of esophageal adenocarcinoma via activation of NADPH oxidase NOX5-S. Am. J. Physiol. Gastrointest. Liver Physiol. 299: G697-G706.
Eads, C.A., R.V. Lord, S.K. Kurumboor, et al. 2000. Fields of aberrant CpG island hypermethylation in Barrett's esophagus and associated adenocarcinoma. Cancer Res. 60: 5021-5026.
Shi, X.Y., B. Bhagwandeen & A.S. Leong. 2008. p16, cyclin D1, Ki-67, and AMACR as markers for dysplasia in Barrett esophagus. Appl. Immunohistochem. Mol. Morphol. 16: 447-452.
Cheng, J.Q., S.C. Jhanwar, Y.Y. Lu & J.R. Testa. 1993. Homozygous deletions within 9p21-p22 identify a small critical region of chromosomal loss in human malignant mesotheliomas. Cancer Res. 53: 4761-4763.
Kuilman, T., C. Michaloglou, W.J. Mooi & D.S. Peeper. 2010. The essence of senescence. Genes Dev. 24: 2463-2479.
Darlavoix, T., W. Seelentag, P. Yan, et al. 2009. Altered expression of CD44 and DKK1 in the progression of Barrett's esophagus to esophageal adenocarcinoma. Virchows Arch. 454: 629-637.
Poehlmann, A., D. Kuester, P. Malfertheiner, et al. 2012. Inflammation and Barrett's carcinogenesis. Pathol. Res. Pract. 208: 269-280.
Corn, P.G., E.I. Heath, R. Heitmiller, et al. 2001. Frequent hypermethylation of the 5′CpG island of E-cadherin in esophageal adenocarcinoma. Clin. Cancer Res. 7: 2765-2769.
Stachler, M.D., A. Taylor-Weiner, S. Peng, et al. 2015. Paired exome analysis of Barrett's esophagus and adenocarcinoma. Nat. Genet. 47: 1047-1055.
Hay, E.D. 1995. An overview of epithelio-mesenchymal transformation. Acta Anat. (Basel) 154: 8-20.
Lee, C.H., K.L. Pan, Y.C. Tang, et al. 2015. LDOC1 silenced by
2009; 89
1998; 281
2010; 16
2004; 445
2012; 123
2010; 19
2002; 97
1997; 275
2015; 143
2016; 31
2000; 92
2003; 50
1993; 366
1998; 153
1997; 8
1998; 152
1950; 38
2004; 210
2001; 61
2009; 13
2006; 208
1997; 50
2010; 24
1994; 269
1997; 57
2006; 25
2008; 21
2006; 281
2014; 17
2008; 112
2010; 2
1998; 11
2001; 414
2009; 69
2010; 38
1990; 249
2007; 282
2000; 114
2006; 55
2014; 46
2009; 454
2007; 96
1995; 154
1993; 105
2012; 228
2001; 20
2016; 11
2014; 306
2011; 301
2011; 305
2002; 62
1993; 53
2002; 122
2010; 299
2015; 110
2005; 129
2005; 7
2005; 6
2014; 35
2014; 260
1999; 30
1999; 112
1998; 77
2014; 31
2004; 64
1995; 71
2003; 116
2011; 711
2015; 347
2002; 117
2002; 115
1998; 115
2014; 63
1999; 80
2003; 95
2012; 208
2009; 58
2015; 47
2013; 13
2000; 60
1999; 96
2011; 27
1994; 107
2001; 96
2009; 23
2009; 22
2015; 6
2015; 5
2002; 291
2013; 45
1997; 132
2008; 16
2013; 305
2013; 41
2006; 15
2008; 14
1999; 1
1996; 59
1991; 6
1996; 56
2016; 55
1998; 24
2004; 111
2011; 103
1995; 83
2012; 2
1997; 71
2015; 29
2001; 7
2004; 17
2013; 133
2001; 3
2016
2015
1998; 106
1999; 398
2009; 1
1994; 4
2008; 294
1994; 54
2005; 58
e_1_2_10_21_1
e_1_2_10_44_1
e_1_2_10_40_1
e_1_2_10_109_1
Washington K. (e_1_2_10_61_1) 1998; 11
e_1_2_10_93_1
e_1_2_10_2_1
e_1_2_10_18_1
e_1_2_10_74_1
e_1_2_10_97_1
e_1_2_10_116_1
e_1_2_10_6_1
e_1_2_10_55_1
e_1_2_10_14_1
e_1_2_10_78_1
e_1_2_10_112_1
e_1_2_10_13_1
e_1_2_10_32_1
e_1_2_10_51_1
e_1_2_10_120_1
e_1_2_10_82_1
Bailey T. (e_1_2_10_60_1) 1998; 152
e_1_2_10_128_1
e_1_2_10_63_1
e_1_2_10_105_1
e_1_2_10_124_1
e_1_2_10_25_1
e_1_2_10_48_1
e_1_2_10_67_1
e_1_2_10_101_1
Timmer M.R. (e_1_2_10_7_1) 2015
e_1_2_10_45_1
e_1_2_10_41_1
e_1_2_10_90_1
Sadot E. (e_1_2_10_86_1) 2002; 115
e_1_2_10_71_1
e_1_2_10_117_1
Wong D.J. (e_1_2_10_36_1) 2001; 61
e_1_2_10_94_1
e_1_2_10_52_1
e_1_2_10_3_1
e_1_2_10_19_1
e_1_2_10_113_1
e_1_2_10_38_1
e_1_2_10_98_1
e_1_2_10_56_1
e_1_2_10_79_1
e_1_2_10_15_1
e_1_2_10_10_1
e_1_2_10_33_1
e_1_2_10_121_1
Corn P.G. (e_1_2_10_70_1) 2001; 7
Hajra K.M. (e_1_2_10_75_1) 2002; 62
Sanz‐Ortega J. (e_1_2_10_37_1) 2003; 50
e_1_2_10_106_1
e_1_2_10_129_1
e_1_2_10_83_1
e_1_2_10_64_1
e_1_2_10_102_1
e_1_2_10_49_1
e_1_2_10_26_1
e_1_2_10_23_1
e_1_2_10_46_1
e_1_2_10_69_1
Tarmin L. (e_1_2_10_27_1) 1994; 54
e_1_2_10_42_1
Zhuang Z. (e_1_2_10_87_1) 1996; 56
Eads C.A. (e_1_2_10_68_1) 2000; 60
e_1_2_10_110_1
Cheng J.Q. (e_1_2_10_29_1) 1993; 53
e_1_2_10_91_1
e_1_2_10_72_1
e_1_2_10_95_1
e_1_2_10_118_1
e_1_2_10_4_1
e_1_2_10_53_1
e_1_2_10_16_1
e_1_2_10_39_1
e_1_2_10_76_1
e_1_2_10_99_1
e_1_2_10_114_1
e_1_2_10_8_1
e_1_2_10_57_1
e_1_2_10_34_1
e_1_2_10_11_1
e_1_2_10_30_1
e_1_2_10_119_1
Bennett W.P. (e_1_2_10_22_1) 1991; 6
e_1_2_10_80_1
e_1_2_10_84_1
e_1_2_10_107_1
e_1_2_10_126_1
e_1_2_10_65_1
e_1_2_10_88_1
e_1_2_10_103_1
e_1_2_10_122_1
e_1_2_10_24_1
e_1_2_10_43_1
e_1_2_10_20_1
e_1_2_10_108_1
James C.D. (e_1_2_10_28_1) 1993; 53
Wong D.J. (e_1_2_10_35_1) 1997; 57
e_1_2_10_92_1
e_1_2_10_73_1
e_1_2_10_115_1
e_1_2_10_96_1
e_1_2_10_54_1
e_1_2_10_5_1
e_1_2_10_17_1
e_1_2_10_77_1
e_1_2_10_111_1
Jankowski J. (e_1_2_10_58_1) 1994; 4
e_1_2_10_12_1
e_1_2_10_9_1
e_1_2_10_59_1
e_1_2_10_31_1
e_1_2_10_50_1
e_1_2_10_81_1
Clemons N.J. (e_1_2_10_125_1) 2014; 17
e_1_2_10_62_1
e_1_2_10_104_1
e_1_2_10_127_1
e_1_2_10_85_1
e_1_2_10_66_1
e_1_2_10_100_1
e_1_2_10_123_1
e_1_2_10_47_1
e_1_2_10_89_1
References_xml – volume: 269
  start-page: 29382
  year: 1994
  end-page: 29384
  article-title: The thioredoxin and glutaredoxin systems are efficient electron donors to human plasma glutathione peroxidase
  publication-title: J. Biol. Chem
– volume: 5
  start-page: e006640
  year: 2015
  article-title: NSAIDs, statins, low‐dose aspirin and PPIs, and the risk of oesophageal adenocarcinoma among patients with Barrett's oesophagus: a population‐based case–control study
  publication-title: BMJ Open
– volume: 123
  start-page: 473
  year: 2012
  end-page: 484
  article-title: Molecular subgroups of medulloblastoma: an international meta‐analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas
  publication-title: Acta Neuropathol
– volume: 117
  start-page: 451
  year: 2002
  end-page: 456
  article-title: Beta‐catenin expression and its association with prognostic factors in adenocarcinoma developed in Barrett esophagus
  publication-title: Am. J. Clin. Pathol
– volume: 16
  start-page: 5669
  year: 2010
  end-page: 5681
  article-title: Biomarkers in Barrett's esophagus and esophageal adenocarcinoma: predictors of progression and prognosis
  publication-title: World J. Gastroenterol
– volume: 96
  start-page: 6937
  year: 1999
  end-page: 6941
  article-title: P19(ARF) stabilizes p53 by blocking nucleo‐cytoplasmic shuttling of mdm2
  publication-title: Proc. Natl. Acad. Sci. U.S.A
– volume: 19
  start-page: 943
  year: 2010
  end-page: 952
  article-title: Allele‐specific CDH1 downregulation and hereditary diffuse gastric cancer
  publication-title: Hum. Mol. Genet
– volume: 1
  start-page: a003053
  year: 2009
  article-title: Structure and biochemistry of cadherins and catenins
  publication-title: Cold Spring Harb. Perspect. Biol
– volume: 122
  start-page: 1113
  year: 2002
  end-page: 1121
  article-title: p16 Inactivation by methylation of the CDKN2A promoter occurs early during neoplastic progression in Barrett's esophagus
  publication-title: Gastroenterology
– volume: 133
  start-page: 214
  year: 2013
  end-page: 224
  article-title: Study of Digestive Health and Australian Cancer Study. Dietary antioxidants and risk of Barrett's esophagus and adenocarcinoma of the esophagus in an Australian population
  publication-title: Int. J. Cancer
– volume: 38
  start-page: 96
  year: 2010
  end-page: 109
  article-title: Oxidative stress and oxidative damage in carcinogenesis
  publication-title: Toxicol. Pathol
– volume: 95
  start-page: 750
  year: 2003
  end-page: 757
  article-title: Serum selenium levels in relation to markers of neoplastic progression among persons with Barrett's esophagus
  publication-title: J. Natl. Cancer Inst
– volume: 11
  start-page: 23
  year: 2016
  article-title: Increasing diagnostic accuracy to grade dysplasia in Barrett's esophagus using an immunohistochemical panel for CDX2, p120ctn, c‐Myc and Jagged1
  publication-title: Diagn. Pathol
– volume: 210
  start-page: 213
  year: 2004
  end-page: 218
  article-title: P53 protein overexpression and p53 mutation analysis in patients with intestinal metaplasia of the cardia and Barrett's esophagus
  publication-title: Cancer Lett
– volume: 24
  start-page: 34
  year: 1998
  end-page: 37
  article-title: Loss of heterozygosity at microsatellite marker sites for tumour suppressor genes in oesophageal adenocarcinoma
  publication-title: Eur. J. Surg. Oncol
– volume: 35
  start-page: 1620
  year: 2014
  end-page: 1628
  article-title: Loss of glutathione peroxidase 7 promotes TNF‐α‐induced NF‐κB activation in Barrett's carcinogenesis
  publication-title: Carcinogenesis
– volume: 31
  start-page: 250
  year: 2014
  article-title: Downregulation of E‐cadherin expression in breast cancer by promoter hypermethylation and its relation with progression and prognosis of tumor
  publication-title: Med. Oncol
– volume: 13
  start-page: 398
  year: 2009
  end-page: 409
  article-title: Progressive silencing of p14ARF in oesophageal adenocarcinoma
  publication-title: J. Cell. Mol. Med
– volume: 25
  start-page: 3084
  year: 2006
  end-page: 3092
  article-title: Alterations of the Wnt signaling pathway during the neoplastic progression of Barrett's esophagus
  publication-title: Oncogene
– volume: 299
  start-page: G697
  year: 2010
  end-page: G706
  article-title: Acid‐induced p16 hypermethylation contributes to development of esophageal adenocarcinoma via activation of NADPH oxidase NOX5‐S
  publication-title: Am. J. Physiol. Gastrointest. Liver Physiol
– volume: 41
  start-page: W518
  year: 2013
  end-page: W522
  article-title: PubTator: a web‐based text mining tool for assisting biocuration
  publication-title: Nucleic Acids Res
– volume: 16
  start-page: 447
  year: 2008
  end-page: 452
  article-title: p16, cyclin D1, Ki‐67, and AMACR as markers for dysplasia in Barrett esophagus
  publication-title: Appl. Immunohistochem. Mol. Morphol
– volume: 114
  start-page: 583
  year: 2000
  end-page: 590
  article-title: Nuclear accumulation of beta‐catenin is a common and early event during neoplastic progression of Barrett esophagus
  publication-title: Am. J. Clin. Pathol
– volume: 21
  start-page: 97
  year: 2008
  end-page: 102
  article-title: Prognostic value of cell adhesion in esophageal adenocarcinomas
  publication-title: Dis. Esophagus
– volume: 281
  start-page: 1509
  year: 1998
  end-page: 1512
  article-title: Identification of c‐MYC as a target of the APC pathway
  publication-title: Science
– volume: 61
  start-page: 8284
  year: 2001
  end-page: 8289
  article-title: P16(INK4a) lesions are common, early abnormalities that undergo clonal expansion in Barrett's metaplastic epithelium
  publication-title: Cancer Res
– volume: 22
  start-page: 588
  year: 2009
  end-page: 595
  article-title: P53 and Ki‐67 overexpression in gastroesophageal reflux disease—Barrett's esophagus and adenocarcinoma sequence
  publication-title: Dis. Esophagus
– volume: 398
  start-page: 422
  year: 1999
  end-page: 426
  article-title: Beta‐catenin regulates expression of cyclin D1 in colon carcinoma cells
  publication-title: Nature
– volume: 17
  start-page: 7
  year: 2014
  end-page: 14
  article-title: Advances in understanding the pathogenesis of Barrett's esophagus
  publication-title: Discov. Med
– volume: 4
  start-page: 441
  year: 1994
  end-page: 448
  article-title: Differential expression of E‐cadherin in normal, metaplastic and dysplastic esophageal mucosa—a putative biomarker
  publication-title: Int. J. Oncol
– volume: 208
  start-page: 269
  year: 2012
  end-page: 280
  article-title: Inflammation and Barrett's carcinogenesis
  publication-title: Pathol. Res. Pract
– volume: 69
  start-page: 9083
  year: 2009
  end-page: 9089
  article-title: In benign Barrett's epithelial cells, acid exposure generates reactive oxygen species that cause DNA double‐strand breaks
  publication-title: Cancer Res
– volume: 122
  start-page: 1569
  year: 2002
  end-page: 1591
  article-title: Barrett's esophagus
  publication-title: Gastroenterology
– volume: 132
  start-page: 728
  year: 1997
  end-page: 733
  article-title: Apoptosis is inhibited early in the dysplasia–carcinoma sequence of Barrett esophagus
  publication-title: Arch. Surg
– volume: 6
  start-page: 25188
  year: 2015
  end-page: 25201
  article-title: LDOC1 silenced by cigarette exposure and involved in oral neoplastic transformation
  publication-title: Oncotarget
– volume: 31
  start-page: 1141
  year: 2016
  end-page: 1146
  article-title: Trends in esophageal cancer survival in United States adults from 1973 to 2009: a SEER database analysis
  publication-title: J. Gastroenterol. Hepatol
– volume: 105
  start-page: 1637
  year: 1993
  end-page: 1642
  article-title: P53 protein accumulation in Barrett's metaplasia, dysplasia, and carcinoma: a follow‐up study
  publication-title: Gastroenterology
– year: 2016
– volume: 92
  start-page: 1805
  year: 2000
  end-page: 1811
  article-title: Hypermethylated APC DNA in plasma and prognosis of patients with esophageal adenocarcinoma
  publication-title: J. Natl. Cancer Inst
– volume: 56
  start-page: 1961
  year: 1996
  end-page: 1964
  article-title: Barrett's esophagus: metaplastic cells with loss of heterozygosity at the APC gene locus are clonal precursors to invasive adenocarcinoma
  publication-title: Cancer Res
– volume: 260
  start-page: 72
  year: 2014
  end-page: 80
  article-title: Comparison of cancer‐associated genetic abnormalities in columnar‐lined esophagus tissues with and without goblet cells
  publication-title: Ann. Surg
– volume: 7
  start-page: 2765
  year: 2001
  end-page: 2769
  article-title: Frequent hypermethylation of the 5′CpG island of E‐cadherin in esophageal adenocarcinoma
  publication-title: Clin. Cancer Res
– volume: 129
  start-page: 1825
  year: 2005
  end-page: 1831
  article-title: Prevalence of Barrett's esophagus in the general population: an endoscopic study
  publication-title: Gastroenterology
– volume: 414
  start-page: 457
  year: 2001
  end-page: 462
  article-title: The E2F1‐3 transcription factors are essential for cellular proliferation
  publication-title: Nature
– volume: 208
  start-page: 100
  year: 2006
  end-page: 107
  article-title: Methylation of APC, TIMP3, and TERT: a new predictive marker to distinguish Barrett's oesophagus patients at risk for malignant transformation
  publication-title: J. Pathol
– volume: 57
  start-page: 2619
  year: 1997
  end-page: 2622
  article-title: P16INK4a promoter is hypermethylated at a high frequency in esophageal adenocarcinomas
  publication-title: Cancer Res
– volume: 347
  start-page: 1260419
  year: 2015
  article-title: Proteomics. Tissue‐based map of the human proteome
  publication-title: Science
– volume: 306
  start-page: G863
  year: 2014
  end-page: G872
  article-title: Role of intracellular calcium and NADPH oxidase NOX5‐S in acid‐induced DNA damage in Barrett's cells and Barrett's esophageal adenocarcinoma cells
  publication-title: Am. J. Physiol. Gastrointest. Liver Physiol
– volume: 53
  start-page: 4761
  year: 1993
  end-page: 4763
  article-title: Homozygous deletions within 9p21‐p22 identify a small critical region of chromosomal loss in human malignant mesotheliomas
  publication-title: Cancer Res
– volume: 291
  start-page: 1138
  year: 2002
  end-page: 1145
  article-title: Transcriptional regulation of the human tumor suppressor p14(ARF) by E2F1, E2F2, E2F3, and Sp1‐like factors
  publication-title: Biochem. Biophys. Res. Commun
– volume: 30
  start-page: 1508
  year: 1999
  end-page: 1514
  article-title: LOH at the sites of the DCC, APC, and TP53 tumor suppressor genes occurs in Barrett's metaplasia and dysplasia adjacent to adenocarcinoma of the esophagus
  publication-title: Hum. Pathol
– volume: 106
  start-page: 11
  year: 1998
  end-page: 17
  article-title: Interphase cytogenetics of esophageal adenocarcinoma and precursor lesions
  publication-title: Cancer Genet. Cytogenet
– volume: 96
  start-page: 1377
  year: 2007
  end-page: 1383
  article-title: Increasing expression of hypoxia‐inducible proteins in the Barrett's metaplasia–dysplasia–adenocarcinoma sequence
  publication-title: Br. J. Cancer
– volume: 58
  start-page: 5
  year: 2009
  end-page: 15
  article-title: DNA hypermethylation regulates the expression of members of the Mu‐class glutathione ‐transferases and glutathione peroxidases in Barrett's adenocarcinoma
  publication-title: Gut
– volume: 96
  start-page: 2839
  year: 2001
  end-page: 2848
  article-title: Predictors of progression in Barrett's esophagus II: baseline 17p (p53) loss of heterozygosity identifies a patient subset at increased risk for neoplastic progression
  publication-title: Am. J. Gastroenterol
– volume: 228
  start-page: 99
  year: 2012
  end-page: 112
  article-title: Activation of Wnt signalling promotes development of dysplasia in Barrett's oesophagus
  publication-title: J. Pathol
– volume: 1
  start-page: 20
  year: 1999
  end-page: 26
  article-title: Nucleolar Arf sequesters Mdm2 and activates p53
  publication-title: Nat. Cell Biol
– volume: 154
  start-page: 8
  year: 1995
  end-page: 20
  article-title: An overview of epithelio‐mesenchymal transformation
  publication-title: Acta Anat. (Basel)
– volume: 294
  start-page: G174
  year: 2008
  end-page: G183
  article-title: STAT5 mediates PAF‐induced NADPH oxidase NOX5‐S expression in Barrett's esophageal adenocarcinoma cells
  publication-title: Am. J. Physiol. Gastrointest. Liver Physiol
– volume: 115
  start-page: 1381
  year: 1998
  end-page: 1386
  article-title: Hypermethylation of the CDKN2/p16 promoter during neoplastic progression in Barrett's esophagus
  publication-title: Gastroenterology
– volume: 281
  start-page: 20368
  year: 2006
  end-page: 20382
  article-title: CAMP‐response element‐binding protein mediates acid‐induced NADPH oxidase NOX5‐S expression in Barrett esophageal adenocarcinoma cells
  publication-title: J. Biol. Chem
– volume: 23
  start-page: 1177
  year: 2009
  end-page: 1182
  article-title: Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS
  publication-title: Genes Dev
– volume: 301
  start-page: G32
  year: 2011
  end-page: G38
  article-title: Glutathione peroxidase‐3 produced by the kidney binds to a population of basement membranes in the gastrointestinal tract and in other tissues
  publication-title: Am. J. Physiol. Gastrointest. Liver Physiol
– volume: 77
  start-page: 277
  year: 1998
  end-page: 286
  article-title: Comparison of p53 and DNA content abnormalities in adenocarcinoma of the oesophagus and gastric cardia
  publication-title: Br. J. Cancer
– volume: 20
  start-page: 7104
  year: 2001
  end-page: 7109
  article-title: INK4a‐ARF alterations and p53 mutations in hepatocellular carcinomas
  publication-title: Oncogene
– volume: 2
  start-page: 899
  year: 2012
  end-page: 905
  article-title: Comparative genomic analysis of esophageal adenocarcinoma and squamous cell carcinoma
  publication-title: Cancer Discov
– volume: 80
  start-page: 1652
  year: 1999
  end-page: 1657
  article-title: E‐cadherin gene mutations are rare in adenocarcinomas of the oesophagus
  publication-title: Br. J. Cancer
– volume: 55
  start-page: 98
  year: 2016
  end-page: 110
  article-title: p53 Reactivation by PRIMA‐1(Met) (APR‐246) sensitises (V600E/K)BRAF melanoma to vemurafenib
  publication-title: Eur. J. Cancer
– volume: 24
  start-page: 2463
  year: 2010
  end-page: 2479
  article-title: The essence of senescence
  publication-title: Genes Dev
– volume: 305
  start-page: 1685
  year: 2011
  end-page: 1694
  article-title: Association of CTNNB1 (β‐catenin) alterations, body mass index, and physical activity with survival in patients with colorectal cancer
  publication-title: JAMA
– volume: 11
  start-page: 805
  year: 1998
  end-page: 813
  article-title: Expression of beta‐catenin, alpha‐catenin, and E‐cadherin in Barrett's esophagus and esophageal adenocarcinomas
  publication-title: Mod. Pathol
– volume: 2
  start-page: a000919
  year: 2010
  article-title: The tumor suppressor p53: from structures to drug discovery
  publication-title: Cold Spring Harb. Perspect. Biol
– volume: 15
  start-page: 509
  year: 2006
  end-page: 516
  article-title: Genetic mechanisms of TP53 loss of heterozygosity in Barrett's esophagus: implications for biomarker validation
  publication-title: Cancer Epidemiol. Biomarkers Prev
– volume: 97
  start-page: 22
  year: 2002
  end-page: 26
  article-title: Reactive oxygen species: are they involved in the pathogenesis of GERD, Barrett's esophagus, and the latter's progression toward esophageal cancer?
  publication-title: Am. J. Gastroenterol
– volume: 53
  start-page: 3674
  year: 1993
  end-page: 3676
  article-title: Localization of chromosome 9p homozygous deletions in glioma cell lines with markers constituting a continuous linkage group
  publication-title: Cancer Res
– volume: 111
  start-page: 224
  year: 2004
  end-page: 228
  article-title: Hypermethylation of tumor suppressor genes (p16INK4A, p14ARF and APC) in adenocarcinomas of the upper gastrointestinal tract
  publication-title: Int. J. Cancer
– volume: 17
  start-page: 322
  year: 2004
  end-page: 327
  article-title: Malignant degeneration of Barrett's esophagus: the role of the Ki‐67 proliferation fraction, expression of E‐cadherin and p53
  publication-title: Dis. Esophagus
– volume: 115
  start-page: 2771
  issue: Pt. 13
  year: 2002
  end-page: 2780
  article-title: Regulation of S33/S37 phosphorylated β‐catenin in normal and transformed cells
  publication-title: J. Cell Sci
– volume: 2
  start-page: a001008
  year: 2010
  article-title: TP53 mutations in human cancers: origins, consequences, and clinical use
  publication-title: Cold Spring Harb. Perspect. Biol
– volume: 445
  start-page: 135
  year: 2004
  end-page: 141
  article-title: INK4a‐ARF alterations in Barrett's epithelium, intraepithelial neoplasia and Barrett's adenocarcinoma
  publication-title: Virchows Arch
– volume: 62
  start-page: 1613
  year: 2002
  end-page: 1618
  article-title: The SLUG zinc‐finger protein represses E‐cadherin in breast cancer
  publication-title: Cancer Res
– volume: 305
  start-page: C1069
  year: 2013
  end-page: C1079
  article-title: Role of NADPH oxidase NOX5‐S, NF‐κB, and DNMT1 in acid‐induced p16 hypermethylation in Barrett's cells
  publication-title: Am. J. Physiol. Cell Physiol
– volume: 64
  start-page: 7629
  year: 2004
  end-page: 7633
  article-title: The combination of genetic instability and clonal expansion predicts progression to esophageal adenocarcinoma
  publication-title: Cancer Res
– volume: 71
  start-page: 355
  year: 1997
  end-page: 359
  article-title: The E‐cadherin gene is silenced by CpG methylation in human hepatocellular carcinomas
  publication-title: Int. J. Cancer
– volume: 71
  start-page: 166
  year: 1995
  end-page: 172
  article-title: E‐cadherin expression in primary and metastatic thoracic neoplasms and in Barrett's oesophagus
  publication-title: Br. J. Cancer
– volume: 47
  start-page: 1047
  year: 2015
  end-page: 1055
  article-title: Paired exome analysis of Barrett's esophagus and adenocarcinoma
  publication-title: Nat. Genet
– volume: 143
  start-page: 1
  year: 2015
  end-page: 9
  article-title: Image analysis of immunohistochemistry is superior to visual scoring as shown for patient outcome of esophageal adenocarcinoma
  publication-title: Histochem. Cell Biol
– volume: 50
  start-page: 212
  year: 1997
  end-page: 217
  article-title: Mutation analysis of the p53, APC, and p16 genes in the Barrett's oesophagus, dysplasia, and adenocarcinoma
  publication-title: J. Clin. Pathol
– volume: 152
  start-page: 135
  year: 1998
  end-page: 144
  article-title: Altered cadherin and catenin complexes in the Barrett's esophagus–dysplasia–adenocarcinoma sequence: correlation with disease progression and dedifferentiation
  publication-title: Am. J. Pathol
– volume: 275
  start-page: 1787
  year: 1997
  end-page: 1790
  article-title: Activation of beta‐catenin–Tcf signaling in colon cancer by mutations in beta‐catenin or APC
  publication-title: Science
– volume: 7
  start-page: 854
  year: 2005
  end-page: 861
  article-title: Hypermethylation and loss of expression of glutathione peroxidase‐3 in Barrett's tumorigenesis
  publication-title: Neoplasia
– volume: 3
  start-page: 289
  year: 2001
  end-page: 293
  article-title: The E‐cadherin/catenin complex: an important gatekeeper in breast cancer tumorigenesis and malignant progression
  publication-title: Breast Cancer Res
– volume: 63
  start-page: 7
  year: 2014
  end-page: 42
  article-title: British society of gastroenterology guidelines on the diagnosis and management of Barrett's oesophagus
  publication-title: Gut
– volume: 116
  start-page: 499
  issue: Pt. 3
  year: 2003
  end-page: 511
  article-title: The transcription factor Slug represses E‐cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors
  publication-title: J. Cell Sci
– volume: 89
  start-page: 385
  year: 2009
  end-page: 397
  article-title: Genome‐wide analysis of genetic alterations in Barrett's adenocarcinoma using single nucleotide polymorphism arrays
  publication-title: Lab. Invest
– volume: 14
  start-page: 1044
  year: 2008
  end-page: 1052
  article-title: Overexpression of Slug is associated with malignant progression of esophageal adenocarcinoma
  publication-title: World J. Gastroenterol
– volume: 58
  start-page: 490
  year: 2005
  end-page: 492
  article-title: A study to determine plasma antioxidant concentrations in patients with Barrett's oesophagus
  publication-title: J. Clin. Pathol
– volume: 54
  start-page: 6094
  year: 1994
  end-page: 6096
  article-title: Frequent loss of heterozygosity on chromosome 9 in adenocarcinoma and squamous cell carcinoma of the esophagus
  publication-title: Cancer Res
– volume: 112
  start-page: 1237
  issue: Pt. 8
  year: 1999
  end-page: 1245
  article-title: E‐cadherin binding prevents beta‐catenin nuclear localization and beta‐catenin/LEF‐1‐mediated transactivation
  publication-title: J. Cell Sci
– volume: 59
  start-page: 3
  year: 1996
  end-page: 10
  article-title: Nuclear localization of β‐catenin by interaction with transcription factor LEF‐1
  publication-title: Mech. Dev
– volume: 29
  start-page: 3528
  year: 2015
  end-page: 3534
  article-title: Reflux control is important in the management of Barrett's esophagus: results from a retrospective 1,830 patient cohort
  publication-title: Surg. Endosc
– volume: 711
  start-page: 193
  year: 2011
  end-page: 201
  article-title: Role of oxidative stress and DNA damage in human carcinogenesis
  publication-title: Mutat. Res
– volume: 60
  start-page: 5021
  year: 2000
  end-page: 5026
  article-title: Fields of aberrant CpG island hypermethylation in Barrett's esophagus and associated adenocarcinoma
  publication-title: Cancer Res
– volume: 366
  start-page: 704
  year: 1993
  end-page: 707
  article-title: A new regulatory motif in cell‐cycle control causing specific inhibition of cyclin D/CDK4
  publication-title: Nature
– volume: 11
  start-page: e0149735
  year: 2016
  article-title: Rho kinase ROCK2 mediates acid‐induced NADPH oxidase NOX5‐S expression in human esophageal adenocarcinoma cells
  publication-title: PLoS One
– year: 2015
  article-title: Derivation of genetic biomarkers for cancer risk stratification in Barrett's oesophagus: a prospective cohort study
  publication-title: Gut
– volume: 83
  start-page: 993
  year: 1995
  end-page: 1000
  article-title: Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
  publication-title: Cell
– volume: 114
  start-page: 890
  year: 2000
  end-page: 895
  article-title: Allelic loss involving the tumor suppressor genes APC and MCC and expression of the APC protein in the development of dysplasia and carcinoma in Barrett esophagus
  publication-title: Am. J. Clin. Pathol
– volume: 249
  start-page: 1049
  year: 1990
  end-page: 1051
  article-title: Transcriptional activation by wild‐type but not transforming mutants of the p53 anti‐oncogene
  publication-title: Science
– volume: 50
  start-page: 404
  year: 2003
  end-page: 407
  article-title: 3p21, 5q21, 9p21 and 17p13.1 allelic deletions are potential markers of individuals with a high risk of developing adenocarcinoma in Barrett's epithelium without dysplasia
  publication-title: Hepatogastroenterology
– volume: 110
  start-page: 828
  year: 2015
  end-page: 834
  article-title: The presence of genetic mutations at key loci predicts progression to esophageal adenocarcinoma in Barrett's esophagus
  publication-title: Am. J. Gastroenterol
– volume: 103
  start-page: 1049
  year: 2011
  end-page: 1057
  article-title: Risk of malignant progression in Barrett's esophagus patients: results from a large population‐based study
  publication-title: J. Natl. Cancer Inst
– volume: 8
  start-page: 287
  year: 1997
  end-page: 301
  article-title: Cyclin D1/Cdk4 regulates retinoblastoma protein‐mediated cell cycle arrest by site‐specific phosphorylation
  publication-title: Mol. Biol. Cell
– volume: 38
  start-page: 175
  year: 1950
  end-page: 182
  article-title: Chronic peptic ulcer of the oesophagus and ‘oesophagitis
  publication-title: Br. J. Surg
– volume: 55
  start-page: 1390
  year: 2006
  end-page: 1397
  article-title: TP53 and progression from Barrett's metaplasia to oesophageal adenocarcinoma in a UK population cohort
  publication-title: Gut
– volume: 63
  start-page: 1229
  year: 2014
  end-page: 1237
  article-title: Acid‐suppressive medications and risk of oesophageal adenocarcinoma in patients with Barrett's oesophagus: a systematic review and meta‐analysis
  publication-title: Gut
– volume: 112
  start-page: 2173
  year: 2008
  end-page: 2180
  article-title: Telomere length and telomerase subunits as diagnostic and prognostic biomarkers in Barrett carcinoma
  publication-title: Cancer
– volume: 71
  start-page: 995
  year: 1995
  end-page: 998
  article-title: Frequent loss of heterozygosity on chromosome 17 at 17q11.2‐q12 in Barrett's adenocarcinoma
  publication-title: Br. J. Cancer
– volume: 282
  start-page: 16244
  year: 2007
  end-page: 16255
  article-title: NADPH oxidase NOX5‐S mediates acid‐induced cyclooxygenase‐2 expression via activation of NF‐κB in Barrett's esophageal adenocarcinoma cells
  publication-title: J. Biol. Chem
– volume: 454
  start-page: 629
  year: 2009
  end-page: 637
  article-title: Altered expression of CD44 and DKK1 in the progression of Barrett's esophagus to esophageal adenocarcinoma
  publication-title: Virchows Arch
– volume: 45
  start-page: 478
  year: 2013
  end-page: 486
  article-title: Exome and whole‐genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity
  publication-title: Nat. Genet
– volume: 6
  start-page: 1779
  year: 1991
  end-page: 1784
  article-title: Archival analysis of p53 genetic and protein alterations in Chinese esophageal cancer
  publication-title: Oncogene
– volume: 153
  start-page: 287
  year: 1998
  end-page: 294
  article-title: Genetic alterations in Barrett esophagus and adenocarcinomas of the esophagus and esophagogastric junction region
  publication-title: Am. J. Pathol
– volume: 46
  start-page: 837
  year: 2014
  end-page: 843
  article-title: Ordering of mutations in preinvasive disease stages of esophageal carcinogenesis
  publication-title: Nat. Genet
– volume: 13
  start-page: 963
  year: 2013
  end-page: 972
  article-title: The role of Snail in EMT and tumorigenesis
  publication-title: Curr. Cancer Drug Targets
– volume: 27
  start-page: 625
  year: 2011
  end-page: 635
  article-title: Hypermethylation‐modulated down‐regulation of CDH1 expression contributes to the progression of esophageal cancer
  publication-title: Int. J. Mol. Med
– volume: 6
  start-page: 622
  year: 2005
  end-page: 634
  article-title: Regulation of cadherin‐mediated adhesion in morphogenesis
  publication-title: Nat. Rev. Mol. Cell Biol
– volume: 107
  start-page: 1759
  year: 1994
  end-page: 1763
  article-title: APC gene mutations in the mutation cluster region are rare in esophageal cancers
  publication-title: Gastroenterology
– year: 2015
  ident: e_1_2_10_7_1
  article-title: Derivation of genetic biomarkers for cancer risk stratification in Barrett's oesophagus: a prospective cohort study
  publication-title: Gut
  contributor:
    fullname: Timmer M.R.
– ident: e_1_2_10_94_1
  doi: 10.1001/jama.2011.513
– ident: e_1_2_10_8_1
  doi: 10.1136/jcp.50.3.212
– ident: e_1_2_10_44_1
  doi: 10.1038/35106593
– ident: e_1_2_10_82_1
  doi: 10.1016/0925-4773(96)00597-7
– volume: 152
  start-page: 135
  year: 1998
  ident: e_1_2_10_60_1
  article-title: Altered cadherin and catenin complexes in the Barrett's esophagus–dysplasia–adenocarcinoma sequence: correlation with disease progression and dedifferentiation
  publication-title: Am. J. Pathol
  contributor:
    fullname: Bailey T.
– ident: e_1_2_10_88_1
  doi: 10.1016/S0046-8177(99)90175-2
– volume: 7
  start-page: 2765
  year: 2001
  ident: e_1_2_10_70_1
  article-title: Frequent hypermethylation of the 5′CpG island of E‐cadherin in esophageal adenocarcinoma
  publication-title: Clin. Cancer Res
  contributor:
    fullname: Corn P.G.
– ident: e_1_2_10_12_1
  doi: 10.1038/bjc.1995.191
– ident: e_1_2_10_2_1
  doi: 10.1002/bjs.18003815005
– ident: e_1_2_10_19_1
  doi: 10.1038/ng.3343
– ident: e_1_2_10_31_1
  doi: 10.1097/SLA.0000000000000424
– ident: e_1_2_10_106_1
  doi: 10.1136/gut.2007.146290
– ident: e_1_2_10_6_1
  doi: 10.1111/j.1572-0241.2001.04236.x
– ident: e_1_2_10_116_1
  doi: 10.1136/bmjopen-2014-006640
– ident: e_1_2_10_20_1
  doi: 10.1016/S0165-4608(98)00036-3
– ident: e_1_2_10_48_1
  doi: 10.1101/gad.1971610
– ident: e_1_2_10_30_1
  doi: 10.1007/s00428-004-1042-0
– ident: e_1_2_10_9_1
  doi: 10.1016/S0002-9440(10)65570-8
– ident: e_1_2_10_38_1
  doi: 10.1016/S0016-5085(98)70016-2
– ident: e_1_2_10_42_1
  doi: 10.1038/366704a0
– ident: e_1_2_10_72_1
  doi: 10.1159/000147748
– volume: 17
  start-page: 7
  year: 2014
  ident: e_1_2_10_125_1
  article-title: Advances in understanding the pathogenesis of Barrett's esophagus
  publication-title: Discov. Med
  contributor:
    fullname: Clemons N.J.
– ident: e_1_2_10_110_1
  doi: 10.18632/oncotarget.4512
– ident: e_1_2_10_95_1
  doi: 10.1007/s00401-012-0958-8
– ident: e_1_2_10_59_1
  doi: 10.1038/bjc.1995.34
– ident: e_1_2_10_79_1
  doi: 10.1309/3QLC-5MF1-JYXU-A5XX
– ident: e_1_2_10_39_1
  doi: 10.1038/ajg.2015.152
– ident: e_1_2_10_99_1
  doi: 10.1126/science.1260419
– ident: e_1_2_10_81_1
  doi: 10.1038/18884
– ident: e_1_2_10_101_1
  doi: 10.1016/j.mrfmmm.2010.12.016
– ident: e_1_2_10_78_1
  doi: 10.1126/science.275.5307.1787
– ident: e_1_2_10_54_1
  doi: 10.1101/cshperspect.a003053
– ident: e_1_2_10_23_1
  doi: 10.1016/j.canlet.2004.01.020
– ident: e_1_2_10_100_1
  doi: 10.1177/0192623309356453
– ident: e_1_2_10_120_1
  doi: 10.1152/ajpgi.00321.2013
– ident: e_1_2_10_63_1
  doi: 10.1111/j.1442-2050.2004.00434.x
– ident: e_1_2_10_16_1
  doi: 10.1101/cshperspect.a001008
– ident: e_1_2_10_57_1
  doi: 10.3892/ijmm.2011.640
– ident: e_1_2_10_117_1
  doi: 10.1007/s00464-015-4103-3
– ident: e_1_2_10_51_1
  doi: 10.1038/sj.onc.1204902
– ident: e_1_2_10_85_1
  doi: 10.1309/1DB6-GFVH-RA6W-Q07Y
– ident: e_1_2_10_112_1
  doi: 10.1074/jbc.M700297200
– ident: e_1_2_10_43_1
  doi: 10.1091/mbc.8.2.287
– volume: 115
  start-page: 2771
  issue: 13
  year: 2002
  ident: e_1_2_10_86_1
  article-title: Regulation of S33/S37 phosphorylated β‐catenin in normal and transformed cells
  publication-title: J. Cell Sci
  doi: 10.1242/jcs.115.13.2771
  contributor:
    fullname: Sadot E.
– volume: 61
  start-page: 8284
  year: 2001
  ident: e_1_2_10_36_1
  article-title: P16(INK4a) lesions are common, early abnormalities that undergo clonal expansion in Barrett's metaplastic epithelium
  publication-title: Cancer Res
  contributor:
    fullname: Wong D.J.
– ident: e_1_2_10_73_1
  doi: 10.1242/jcs.00224
– ident: e_1_2_10_10_1
  doi: 10.1158/0008-5472.CAN-04-1738
– ident: e_1_2_10_114_1
  doi: 10.1152/ajpgi.00186.2010
– ident: e_1_2_10_115_1
  doi: 10.1136/gutjnl-2013-305997
– volume: 56
  start-page: 1961
  year: 1996
  ident: e_1_2_10_87_1
  article-title: Barrett's esophagus: metaplastic cells with loss of heterozygosity at the APC gene locus are clonal precursors to invasive adenocarcinoma
  publication-title: Cancer Res
  contributor:
    fullname: Zhuang Z.
– ident: e_1_2_10_76_1
  doi: 10.1007/s00418-014-1258-2
– ident: e_1_2_10_32_1
  doi: 10.1038/labinvest.2008.67
– ident: e_1_2_10_14_1
  doi: 10.1038/ng.2591
– ident: e_1_2_10_24_1
  doi: 10.1136/gut.2005.083295
– ident: e_1_2_10_126_1
  doi: 10.1093/carcin/bgu083
– volume: 60
  start-page: 5021
  year: 2000
  ident: e_1_2_10_68_1
  article-title: Fields of aberrant CpG island hypermethylation in Barrett's esophagus and associated adenocarcinoma
  publication-title: Cancer Res
  contributor:
    fullname: Eads C.A.
– ident: e_1_2_10_15_1
  doi: 10.1158/2159-8290.CD-12-0189
– ident: e_1_2_10_49_1
  doi: 10.1002/ijc.20212
– volume: 11
  start-page: 805
  year: 1998
  ident: e_1_2_10_61_1
  article-title: Expression of beta‐catenin, alpha‐catenin, and E‐cadherin in Barrett's esophagus and esophageal adenocarcinomas
  publication-title: Mod. Pathol
  contributor:
    fullname: Washington K.
– ident: e_1_2_10_50_1
  doi: 10.1101/gad.511109
– ident: e_1_2_10_74_1
  doi: 10.2174/15680096113136660102
– ident: e_1_2_10_62_1
  doi: 10.1007/s00428-009-0769-z
– ident: e_1_2_10_65_1
  doi: 10.1186/bcr309
– ident: e_1_2_10_47_1
  doi: 10.1006/bbrc.2002.6591
– ident: e_1_2_10_104_1
  doi: 10.1016/j.prp.2012.03.007
– ident: e_1_2_10_25_1
  doi: 10.1136/gutjnl-2013-305372
– volume: 54
  start-page: 6094
  year: 1994
  ident: e_1_2_10_27_1
  article-title: Frequent loss of heterozygosity on chromosome 9 in adenocarcinoma and squamous cell carcinoma of the esophagus
  publication-title: Cancer Res
  contributor:
    fullname: Tarmin L.
– ident: e_1_2_10_46_1
  doi: 10.1038/8991
– ident: e_1_2_10_118_1
  doi: 10.1152/ajpcell.00080.2013
– ident: e_1_2_10_69_1
  doi: 10.1002/path.1884
– ident: e_1_2_10_90_1
  doi: 10.1093/jnci/92.22.1805
– ident: e_1_2_10_41_1
  doi: 10.1016/0092-8674(95)90214-7
– volume: 4
  start-page: 441
  year: 1994
  ident: e_1_2_10_58_1
  article-title: Differential expression of E‐cadherin in normal, metaplastic and dysplastic esophageal mucosa—a putative biomarker
  publication-title: Int. J. Oncol
  contributor:
    fullname: Jankowski J.
– ident: e_1_2_10_105_1
  doi: 10.1593/neo.05328
– ident: e_1_2_10_121_1
  doi: 10.1053/j.gastro.2005.08.053
– ident: e_1_2_10_11_1
  doi: 10.1158/1055-9965.EPI-05-0246
– ident: e_1_2_10_96_1
  doi: 10.1152/ajpgi.00064.2011
– ident: e_1_2_10_56_1
  doi: 10.1002/(SICI)1097-0215(19970502)71:3<355::AID-IJC8>3.0.CO;2-X
– volume: 6
  start-page: 1779
  year: 1991
  ident: e_1_2_10_22_1
  article-title: Archival analysis of p53 genetic and protein alterations in Chinese esophageal cancer
  publication-title: Oncogene
  contributor:
    fullname: Bennett W.P.
– volume: 53
  start-page: 3674
  year: 1993
  ident: e_1_2_10_28_1
  article-title: Localization of chromosome 9p homozygous deletions in glioma cell lines with markers constituting a continuous linkage group
  publication-title: Cancer Res
  contributor:
    fullname: James C.D.
– ident: e_1_2_10_108_1
  doi: 10.1002/ijc.28016
– ident: e_1_2_10_21_1
  doi: 10.1111/j.1442-2050.2009.00953.x
– ident: e_1_2_10_3_1
  doi: 10.1093/nar/gkt441
– ident: e_1_2_10_92_1
  doi: 10.1097/PAI.0b013e318168598b
– ident: e_1_2_10_71_1
  doi: 10.3748/wjg.14.1044
– volume: 62
  start-page: 1613
  year: 2002
  ident: e_1_2_10_75_1
  article-title: The SLUG zinc‐finger protein represses E‐cadherin in breast cancer
  publication-title: Cancer Res
  contributor:
    fullname: Hajra K.M.
– ident: e_1_2_10_111_1
  doi: 10.1074/jbc.M603353200
– ident: e_1_2_10_64_1
  doi: 10.1111/j.1442-2050.2007.00749.x
– ident: e_1_2_10_91_1
  doi: 10.1016/0016-5085(94)90818-4
– ident: e_1_2_10_66_1
  doi: 10.1093/hmg/ddp537
– ident: e_1_2_10_107_1
  doi: 10.1136/jcp.2004.023721
– volume: 53
  start-page: 4761
  year: 1993
  ident: e_1_2_10_29_1
  article-title: Homozygous deletions within 9p21‐p22 identify a small critical region of chromosomal loss in human malignant mesotheliomas
  publication-title: Cancer Res
  contributor:
    fullname: Cheng J.Q.
– ident: e_1_2_10_122_1
  doi: 10.1093/jnci/djr203
– ident: e_1_2_10_124_1
  doi: 10.1053/gast.2002.33427
– volume: 57
  start-page: 2619
  year: 1997
  ident: e_1_2_10_35_1
  article-title: P16INK4a promoter is hypermethylated at a high frequency in esophageal adenocarcinomas
  publication-title: Cancer Res
  contributor:
    fullname: Wong D.J.
– ident: e_1_2_10_129_1
  doi: 10.1001/archsurg.1997.01430310042007
– ident: e_1_2_10_33_1
  doi: 10.1016/S0748-7983(98)80122-4
– ident: e_1_2_10_84_1
  doi: 10.1038/sj.onc.1209338
– ident: e_1_2_10_17_1
  doi: 10.1126/science.2144364
– volume: 50
  start-page: 404
  year: 2003
  ident: e_1_2_10_37_1
  article-title: 3p21, 5q21, 9p21 and 17p13.1 allelic deletions are potential markers of individuals with a high risk of developing adenocarcinoma in Barrett's epithelium without dysplasia
  publication-title: Hepatogastroenterology
  contributor:
    fullname: Sanz‐Ortega J.
– ident: e_1_2_10_83_1
  doi: 10.1002/path.4058
– ident: e_1_2_10_89_1
  doi: 10.1309/L1Q3-E3AQ-APU9-NA0A
– ident: e_1_2_10_26_1
  doi: 10.1016/j.ejca.2015.12.002
– ident: e_1_2_10_109_1
  doi: 10.1093/jnci/95.10.750
– ident: e_1_2_10_53_1
  doi: 10.1038/nrm1699
– ident: e_1_2_10_93_1
  doi: 10.1186/s13000-016-0473-7
– ident: e_1_2_10_103_1
  doi: 10.1158/0008-5472.CAN-09-2518
– ident: e_1_2_10_97_1
  doi: 10.1016/S0021-9258(18)43889-6
– ident: e_1_2_10_127_1
  doi: 10.1002/cncr.23419
– ident: e_1_2_10_55_1
  doi: 10.1007/s12032-014-0250-y
– ident: e_1_2_10_113_1
  doi: 10.1152/ajpgi.00291.2007
– ident: e_1_2_10_4_1
  doi: 10.1101/cshperspect.a000919
– ident: e_1_2_10_123_1
  doi: 10.1111/jgh.13289
– ident: e_1_2_10_67_1
  doi: 10.1038/sj.bjc.6690577
– ident: e_1_2_10_40_1
  doi: 10.3748/wjg.v16.i45.5669
– ident: e_1_2_10_45_1
  doi: 10.1073/pnas.96.12.6937
– ident: e_1_2_10_52_1
  doi: 10.1111/j.1582-4934.2008.00336.x
– ident: e_1_2_10_98_1
– ident: e_1_2_10_5_1
  doi: 10.1016/0016-5085(93)91058-P
– ident: e_1_2_10_34_1
  doi: 10.1053/gast.2002.32370
– ident: e_1_2_10_119_1
  doi: 10.1371/journal.pone.0149735
– ident: e_1_2_10_128_1
  doi: 10.1038/sj.bjc.6603744
– ident: e_1_2_10_13_1
  doi: 10.1038/bjc.1998.44
– ident: e_1_2_10_18_1
  doi: 10.1038/ng.3013
– ident: e_1_2_10_77_1
  doi: 10.1242/jcs.112.8.1237
– ident: e_1_2_10_102_1
  doi: 10.1111/j.1572-0241.2002.05444.x
– ident: e_1_2_10_80_1
  doi: 10.1126/science.281.5382.1509
SSID ssj0012847
Score 2.38036
SecondaryResourceType review_article
Snippet Esophageal adenocarcinoma (EAC) develops in the sequential transformation of normal epithelium into metaplastic epithelium, called Barrett's esophagus (BE),...
SourceID proquest
crossref
pubmed
wiley
istex
SourceType Aggregation Database
Index Database
Publisher
StartPage 74
SubjectTerms Accumulation
Adenocarcinoma
Adenocarcinoma - diagnosis
Adenocarcinoma - genetics
Adenocarcinoma - metabolism
Animals
Barrett Esophagus - diagnosis
Barrett Esophagus - genetics
Barrett Esophagus - metabolism
Barrett's esophagus
Biochemistry
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Cancer
cancer progression
Correlation
Cyclin-Dependent Kinase Inhibitor p18 - genetics
Cyclin-Dependent Kinase Inhibitor p18 - metabolism
Data mining
Disease Progression
Documents
Dysplasia
E-cadherin
Epithelium
esophageal adenocarcinoma
Esophageal cancer
Esophageal Neoplasms - diagnosis
Esophageal Neoplasms - genetics
Esophageal Neoplasms - metabolism
Esophagus
Extraction
Genes
Genetic transformation
genomic alterations
Health risk assessment
Health risks
Humans
Intestine
Membrane Proteins - genetics
Membrane Proteins - metabolism
NADPH Oxidase 5
NADPH Oxidases - genetics
NADPH Oxidases - metabolism
p53 Protein
Patients
Reactive Oxygen Species - metabolism
Risk factors
Transcription
Tumor Suppressor Protein p53 - genetics
Tumor Suppressor Protein p53 - metabolism
Title Overview of major molecular alterations during progression from Barrett's esophagus to esophageal adenocarcinoma
URI https://api.istex.fr/ark:/67375/WNG-7LK2FJ25-F/fulltext.pdf
https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fnyas.13134
https://www.ncbi.nlm.nih.gov/pubmed/27415609
https://www.proquest.com/docview/1833137331
https://www.proquest.com/docview/1908371177
https://search.proquest.com/docview/1826717990
https://search.proquest.com/docview/1837321784
Volume 1381
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3db9MwED-NVUi8IDa-AmMyAvElFaWOHScSLy0jTAMKAqaNp8iJHQSoydS0wP577uwkMGmahPKSKI7j-Hzn38Xn3wE81FXJhQrDsTImRQeFVCqOinFYWXR7JmYiHLv-u3m8fygOjuXxBrzo98J4fojhhxtphrPXpOC6aP9R8vpUt88n0SQSl2CEuCam_AVcfBjWEMjwOjus0A4jjunISSmO5--zZ6ajEfXs7_Ow5lno6uae7Bpc7UAjm3opb8GGrbfhsk8jeboNW52CtuxJxyL99DqcvP9JZsD-Yk3FFvp7s2SLPhUuc2vk_l8d8xsVmQvU8iQdjPacsJkP4n3cMkupDvTXdctWTX-B-JJptFk4FS7Lb3Wz0DfgMHv1-eX-uEuvMC4Fel04N5XKFGEVWZkW0upYlIVGdbYqNIojDAhjXiYRQjLEIEpHJhIlR9spTSK5THh0Ezbrpra3gRGPfWWskqmI6UiElTE6LiapdIkgJYAHfS_nJ55FI--9D5JF7mQRwCMngKGIXv6guDMl86P561y9fcOzAy7zLICdXkJ5p3JYRRJhJZSC8vzbKYJNRUvUAdwfbqMu0QKJrm2zpip4rIgiL7yoDL4D_bgEm3vLD46hvUQFhAgyDeCZGy0XfGs-_zL95M7u_E_hu3AFEVvsowl3YHO1XNt7iIpWxa4b_Lswms72Zhle7X3kfwAw3AdU
link.rule.ids 314,780,784,1375,11562,27924,27925,46052,46294,46476,46718
linkProvider Wiley-Blackwell
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwED_BJsRegA0YgQFGIL6kVokTx8nj-Chl64oEmxhPkeM4CKYmU9MC46_nzk4CQ9MkUF4S2XES5-78O_v8O4BHqtQ8kr4_kEWRooNCKhWH-cAvDbo9QRFEll1_bxqPD6KdQ3HYxubQXhjHD9FPuJFmWHtNCk4T0n9oeXWimmEQBmF0EVZR3wOK6Hr1vmePspbXGmKJhhiBTMtOSoE8v-89NR6tUtf-OAtsnsaudvAZXXUZVhvLWUgxJ0fD5SIf6p9_MTr-93ddgystLGXbTo7W4YKpNuCSS1R5sgHrrQlo2NOWp_rZdTh-940MjfnO6pLN1Nd6zmZdsl1mV-HdbCBzWyGZDQVzNCCMdrWwFy5M-EnDDCVTUJ-XDVvU3QUiWKbQKuJgO9dfqnqmbsDB6PX-y_GgTeAw0BH6dTj6aVnkfhkakebCqDjSuUKDYaRfSI5Aw4-5TkIEfYhypAqLMNIcrbMoEsFFwsObsFLVlbkFjJjyy8JIkUYxHUlkRIyuUZGUSiMM8uBh9xuzY8fTkXX-DXVoZjvUg8f2D_dV1PyIItukyD5O32RysstHO1xkIw-2OhHIWqXGJpIQG6Ekl2cXpwhnJS2Ce_CgL0ZtpSUYVZl6SU1wFFSJEOC8OvgM9BQTfN1NJ339-xLZEGLU1IPnVobO-dZs-mn7gz27_S-V78Pl8f7eJJu8ne7egTXEh7GLXdyClcV8ae4iBlvk96ym_QK6Gima
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3bbtQwEB2VViBegJZboIARiJu0q6xjx4nES6GE0pYFFSrKA4qc2EFQbbLaC1C-nhk7WSiqKoH2Jas4juN4js_E4zMA93VVcqHCsKeMSdFBIZOKo6IXVhbdnoEZCKeu_3oYb-2L7QN5sARPu70wXh9i8cGNLMPhNRn42FR_GHl9pKf9QTSIxBlYETFPSTl_c28hHuWA1-GwQhxGHtOKk1Icz-9rj01HK9SzP07imsepq5t7sovwqWu1Dzk57M9nRb_8-Zeg4_8-1iW40JJStuFH0Sos2XoNzvo0lUdrsNoCwJQ9alWqH1-G8ZtvBDP2O2sqNtJfmwkbdal2mVuD998Cmd8IyVwgmBcBYbSnhT3zQcIPp8xSKgX9eT5ls6b7g_yVacREnGon5Ze6GekrsJ-9eP98q9emb-iVAr06nPtKZYqwiqxMC2l1LMpCI1xYFRrFkWaEMS-TCCkfchylIxOJkiM2S5NILhMeXYXluqntdWCkk18Zq2QqYvolwsoYHSOTVLpEEhTAve4t5mOv0pF33g11aO46NIAH7gUviujJIcW1KZl_GL7M1e4Oz7a5zLMA1rsRkLcmjVUkEVZCKS5PPp0imVW0BB7A3cVptFVagNG1beZUBY8VSfCFp5XBe6CfmGBzr_nBt2gvSQ0hQ00DeOKG0CnPmg8_brxzRzf-pfAdOPd2M8t3Xw13bsJ5JIexD1xch-XZZG5vIQGbFbednf0CGtYoSQ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Overview+of+major+molecular+alterations+during+progression+from+Barrett%27s+esophagus+to+esophageal+adenocarcinoma&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.au=Kalatskaya%2C+Irina&rft.date=2016-10-01&rft.pub=Wiley+Subscription+Services%2C+Inc&rft.issn=0077-8923&rft.eissn=1749-6632&rft.volume=1381&rft.issue=1&rft.spage=74&rft_id=info:doi/10.1111%2Fnyas.13134&rft.externalDBID=NO_FULL_TEXT&rft.externalDocID=4231152111
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0077-8923&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0077-8923&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0077-8923&client=summon