Clinical efficacy of tacrolimus in systemic lupus erythematosus with various manifestations: a real-world study
Based on the Chinese SLE Treatment and Research group registry,[3] SLE patients who fulfill the 2012 Systemic Lupus International Collaborating Clinics classification criteria and with a Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) ≥2 were included from March 2016 to March 20...
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| Published in | Chinese medical journal Vol. 135; no. 18; pp. 2245 - 2247 |
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| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
China
Lippincott Williams & Wilkins
20.09.2022
Lippincott Williams & Wilkins Ovid Technologies Wolters Kluwer |
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| Abstract | Based on the Chinese SLE Treatment and Research group registry,[3] SLE patients who fulfill the 2012 Systemic Lupus International Collaborating Clinics classification criteria and with a Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) ≥2 were included from March 2016 to March 2020 in Peking Union Medical College Hospital. According to the European consensus criteria, SLE remission was defined as a clinical SLEDAI-2K = 0 and PGA <0.5, with prednisolone (or equivalent) ≤5 mg daily. Pulmonary arterial hypertension (PAH) was defined as a resting mean pulmonary artery pressure >25 mmHg assessed by right heart catheterization, in the presence of normal pulmonary capillary wedge pressure <15 mmHg and pulmonary vascular resistance >3 Wood units, or a resting systolic pulmonary artery pressure >40 mmHg estimated by transthoracic echocardiography. According to our study, tacrolimus combined with or without vasodilator therapy might improve not only the SLEDAI-2K score but also the heart function of patients with SLE-PAH. |
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| AbstractList | Based on the Chinese SLE Treatment and Research group registry,[3] SLE patients who fulfill the 2012 Systemic Lupus International Collaborating Clinics classification criteria and with a Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) ≥2 were included from March 2016 to March 2020 in Peking Union Medical College Hospital. According to the European consensus criteria, SLE remission was defined as a clinical SLEDAI-2K = 0 and PGA <0.5, with prednisolone (or equivalent) ≤5 mg daily. Pulmonary arterial hypertension (PAH) was defined as a resting mean pulmonary artery pressure >25 mmHg assessed by right heart catheterization, in the presence of normal pulmonary capillary wedge pressure <15 mmHg and pulmonary vascular resistance >3 Wood units, or a resting systolic pulmonary artery pressure >40 mmHg estimated by transthoracic echocardiography. According to our study, tacrolimus combined with or without vasodilator therapy might improve not only the SLEDAI-2K score but also the heart function of patients with SLE-PAH. |
| Author | Tian, Xinping Li, Mengtao Zhang, Shangzhu Zeng, Xiaofeng Peng, Liying Wang, Qian Zhou, Shuang Zhao, Yan Zhao, Jiuliang Leng, Xiaomei Bai, Wei Wang, Yanhong |
| AuthorAffiliation | Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science and Technology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital (PUMCH), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing 100730, China Department of Epidemiology and Bio-statistics (YW), Institute of Basic Medical Science, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100053, China |
| AuthorAffiliation_xml | – name: Department of Epidemiology and Bio-statistics (YW), Institute of Basic Medical Science, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100053, China – name: Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science and Technology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital (PUMCH), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing 100730, China |
| Author_xml | – sequence: 1 givenname: Wei surname: Bai fullname: Bai, Wei organization: Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science and Technology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital (PUMCH), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing 100730, China – sequence: 2 givenname: Mengtao surname: Li fullname: Li, Mengtao organization: Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science and Technology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital (PUMCH), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing 100730, China – sequence: 3 givenname: Shuang surname: Zhou fullname: Zhou, Shuang organization: Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science and Technology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital (PUMCH), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing 100730, China – sequence: 4 givenname: Liying surname: Peng fullname: Peng, Liying organization: Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science and Technology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital (PUMCH), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing 100730, China – sequence: 5 givenname: Jiuliang surname: Zhao fullname: Zhao, Jiuliang organization: Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science and Technology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital (PUMCH), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing 100730, China – sequence: 6 givenname: Xinping surname: Tian fullname: Tian, Xinping organization: Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science and Technology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital (PUMCH), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing 100730, China – sequence: 7 givenname: Qian surname: Wang fullname: Wang, Qian organization: Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science and Technology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital (PUMCH), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing 100730, China – sequence: 8 givenname: Xiaomei surname: Leng fullname: Leng, Xiaomei organization: Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science and Technology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital (PUMCH), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing 100730, China – sequence: 9 givenname: Shangzhu surname: Zhang fullname: Zhang, Shangzhu organization: Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science and Technology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital (PUMCH), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing 100730, China – sequence: 10 givenname: Yanhong surname: Wang fullname: Wang, Yanhong organization: Department of Epidemiology and Bio-statistics (YW), Institute of Basic Medical Science, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100053, China – sequence: 11 givenname: Yan surname: Zhao fullname: Zhao, Yan organization: Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science and Technology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital (PUMCH), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing 100730, China – sequence: 12 givenname: Xiaofeng surname: Zeng fullname: Zeng, Xiaofeng organization: Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science and Technology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital (PUMCH), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing 100730, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35946790$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1183/13993003.02449-2016 10.1136/annrheumdis-2020-216924 10.1177/0961203313499086 10.1136/annrheumdis-2015-207726 10.1136/annrheumdis-2013-205139 |
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| References_xml | – volume: 50 start-page: 1602449 year: 2017 ident: R5-20250603 article-title: Randomised placebo-controlled safety and tolerability trial of FK506 (tacrolimus) for pulmonary arterial hypertension publication-title: Eur Respir J doi: 10.1183/13993003.02449-2016 – volume: 79 start-page: 713 year: 2020 ident: R2-20250603 article-title: 2019 update of the Joint European League against Rheumatism and European Renal Association-European Dialysis and Transplant Association (EULAR/ERA-EDTA) recommendations for the management of lupus nephritis publication-title: Ann Rheum Dis doi: 10.1136/annrheumdis-2020-216924 – volume: 22 start-page: 1192 year: 2013 ident: R3-20250603 article-title: Chinese SLE treatment and research group (CSTAR) registry: I. Major clinical characteristics of Chinese patients with systemic lupus erythematosus publication-title: Lupus doi: 10.1177/0961203313499086 – volume: 75 start-page: 1615 year: 2016 ident: R4-20250603 article-title: Definition and initial validation of a Lupus Low Disease Activity State (LLDAS) publication-title: Ann Rheum Dis doi: 10.1136/annrheumdis-2015-207726 – volume: 73 start-page: 958 year: 2014 ident: R1-20250603 article-title: Treat-to-target in systemic lupus erythematosus: recommendations from an international task force publication-title: Ann Rheum Dis doi: 10.1136/annrheumdis-2013-205139 |
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| SubjectTerms | Arthritis Cardiac catheterization Humans Hypertension Immunosuppressive agents Immunosuppressive Agents - therapeutic use Intubation Lupus Lupus Erythematosus, Systemic - drug therapy Proteins Pulmonary arteries Remission (Medicine) Tacrolimus - therapeutic use Thrombocytopenia Treatment Outcome |
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| Title | Clinical efficacy of tacrolimus in systemic lupus erythematosus with various manifestations: a real-world study |
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