Phosphorylation and Stabilization of PIN1 by JNK Promote Intrahepatic Cholangiocarcinoma Growth - Lepore, Alessio; Choy, Pui Man; Lee, Nathan C.W.; Carella, Maria Annunziata; Favicchio, Rosy; Briones‐Orta, Marco A.; Glaser, Shannon S.; Alpini, Gianfranco; D’Santos, Clive; Tooze, Reuben M.; Lorger, Mihaela; Syn, Wing‐Kin; et al. (Hepatology (Baltimore, Md.), 2021)
Keywords: Animals; Antineoplastic Agents - administration & dosage; Bile Duct Neoplasms - drug therapy; Bile Duct Neoplasms - genetics; Bile Duct Neoplasms - metabolism; Bile Duct Neoplasms - pathology; Carcinogenesis - drug effects; Carcinogenesis - genetics; Carcinogenesis - metabolism; Cell Line, Tumor; Cell proliferation; Cholangiocarcinoma; Cholangiocarcinoma - drug therapy; Cholangiocarcinoma - genetics; Cholangiocarcinoma - metabolism; Cholangiocarcinoma - pathology; Female; Gene Knockdown Techniques; Hepatology; Humans; JNK protein; Kinases; Liver cancer; MAP Kinase Signaling System - drug effects; MAP Kinase Signaling System - genetics; Mice; Mice, Inbred NOD; Mice, SCID; Mitogen-Activated Protein Kinase 8 - genetics; Mitogen-Activated Protein Kinase 8 - metabolism; Mitogen-Activated Protein Kinase 9 - genetics; Mitogen-Activated Protein Kinase 9 - metabolism; NIMA-Interacting Peptidylprolyl Isomerase - antagonists & inhibitors; NIMA-Interacting Peptidylprolyl Isomerase - genetics; NIMA-Interacting Peptidylprolyl Isomerase - metabolism; Phosphorylation; Phosphorylation - drug effects; Phosphorylation - genetics; Pin1 protein; Proteasomes; Retinoic acid; RNA, Small Interfering - genetics; Therapeutic targets; Tretinoin - administration & dosage; Tumor Burden - drug effects; Tumor Burden - genetics; Tumorigenesis; Ubiquitination; Xenograft Model Antitumor Assays; Xenografts