Rnd3/RhoE Modulates Hypoxia-Inducible Factor 1α/Vascular Endothelial Growth Factor Signaling by Stabilizing Hypoxia-Inducible Factor 1α and Regulates Responsive Cardiac Angiogenesis

• Published in: Hypertension (Dallas, Tex. 1979) Vol. 67; no. 3; pp. 597 - 605
• Main Authors: Yue, Xiaojing, Lin, Xi, Yang, Tingli, Yang, Xiangsheng, Yi, Xin, Jiang, Xuejun, Li, Xiaoyan, Li, Tianfa, Guo, Junli, Dai, Yuan, Shi, Jianjian, Wei, Lei, Youker, Keith A., Torre-Amione, Guillermo, Yu, Yanhong, Andrade, Kelsey C., Chang, Jiang
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 01.03.2016
• Subjects: Animals; Blotting, Western; Coronary Vessels - metabolism; Coronary Vessels - pathology; Disease Models, Animal; Endothelium, Vascular - metabolism; Endothelium, Vascular - pathology; Gene Expression Regulation; Humans; Hypertension - genetics; Hypertension - metabolism; Hypertension - pathology; Hypoxia-Inducible Factor 1, alpha Subunit - biosynthesis; Hypoxia-Inducible Factor 1, alpha Subunit - genetics; Mice; Mice, Knockout; Mice, Transgenic; Neovascularization, Pathologic - genetics; Neovascularization, Pathologic - metabolism; rho GTP-Binding Proteins - biosynthesis; rho GTP-Binding Proteins - genetics; RNA - genetics; Signal Transduction; Vascular Endothelial Growth Factor A - biosynthesis; Vascular Endothelial Growth Factor A - genetics; heart failure; G-protein; angiogenesis factor; hypertrophy; hypertension; vascular endothelial growth factor A
• ISSN: 0194-911X; 1524-4563
• DOI: 10.1161/HYPERTENSIONAHA.115.06412

The insufficiency of compensatory angiogenesis in the heart of patients with hypertension contributes to heart failure transition. The hypoxia-inducible factor 1α–vascular endothelial growth factor (HIF1α–VEGF) signaling cascade controls responsive angiogenesis. One of the challenges in reprograming...