Capture of extracellular zinc ions by astrocytes

• Published in: Glia Vol. 54; no. 4; pp. 304 - 315
• Main Authors: Varea, Emilio, Alonso-Llosà, Gregori, Molowny, Asunción, Lopez-Garcia, Carlos, Ponsoda, Xavier
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.09.2006; Wiley-Liss
• Subjects: Animals; Astrocytes - drug effects; Astrocytes - metabolism; Astrocytes - ultrastructure; Biological and medical sciences; Cells, Cultured; Dose-Response Relationship, Drug; endocytosis; Endosomes - physiology; Endosomes - ultrastructure; Extracellular Space - drug effects; Extracellular Space - metabolism; fluorescence; Fundamental and applied biological sciences. Psychology; glia; Glial Fibrillary Acidic Protein - metabolism; Homeostasis; Immunohistochemistry; Isolated neuron and nerve. Neuroglia; Microscopy, Electron; Organelles - physiology; Organelles - ultrastructure; Rabbits; Sucrose - pharmacology; TSQ; Vertebrates: nervous system and sense organs; zinc; Zinc - metabolism; Glial cell; Endocytosis; TSQ; fluorescence; Neuroglia; Central nervous system; Astrocyte; Extracellular; glia; Zinc

Synaptic zinc ions released during synaptic transmission interact with pre‐ and postsynaptic neuroreceptors, thus modulating neurotransmission. It is likely that they have to be efficiently cleared from the extracellular milieu to assure subsequent synaptic events. Both neurons and glia are assumed...