Alcohol Stimulates Activation of Snail, Epidermal Growth Factor Receptor Signaling, and Biomarkers of Epithelial-Mesenchymal Transition in Colon and Breast Cancer Cells

• Published in: Alcoholism, clinical and experimental research Vol. 34; no. 1; pp. 19 - 31
• Main Authors: Forsyth, Christopher B., Tang, Yueming, Shaikh, Maliha, Zhang, Lijuan, Keshavarzian, Ali
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.01.2010; Wiley
• Subjects: Active Transport, Cell Nucleus - physiology; Alcohol; Alcoholism - metabolism; Alcoholism - pathology; Alcoholism and acute alcohol poisoning; Biological and medical sciences; Biomarkers, Tumor - metabolism; Breast Neoplasms - metabolism; Caco-2 Cells; Cancer; Cell Line; Cell Line, Tumor; Cell Movement - drug effects; Cell Movement - physiology; Colonic Neoplasms - metabolism; Epidermal Growth Factor Receptor; Epithelial Cells - drug effects; Epithelial Cells - metabolism; Epithelial-Mesenchymal Transition; Ethanol - pharmacology; Female; Gynecology. Andrology. Obstetrics; Humans; Male; Mammary gland diseases; Medical sciences; Mesoderm - drug effects; Mesoderm - metabolism; Receptor, Epidermal Growth Factor - physiology; Signal Transduction - drug effects; Signal Transduction - physiology; Snail; Snail Family Transcription Factors; Toxicology; Transcription Factors - metabolism; Tumors; Breast disease; Ethanol; Digestive system; Gut; Biological marker; Alcohol; Activation; Breast cancer; Gastropoda; Mesenchymal cell; Malignant tumor; Snail; Epidermal growth factor receptor; Mammary gland diseases; Alcoholic beverage; Signal transduction; Growth factor receptor; Epithelial-Mesenchymal Transition; Female; Colon; Invertebrata; Mollusca; Tumor cell; Cancer

Background:  Alcohol consumption is associated with the risk of progressive cancers including colon and breast cancer. The mechanisms for the alcohol‐induced aggressive behavior of these epithelial cancer cells have not been fully identified. Epithelial–mesenchymal transition (EMT) is a developmenta...