The Serum Proteome and Ursodeoxycholic Acid Response in Primary Biliary Cholangitis

• Published in: Hepatology (Baltimore, Md.) Vol. 74; no. 6; pp. 3269 - 3283
• Main Authors: Barron‐Millar, Ben, Ogle, Laura, Mells, George, Flack, Steven, Badrock, Jonathan, Sandford, Richard, Kirby, John, Palmer, Jeremy, Jopson, Laura, Brain, John, Smith, Graham R., Rushton, Steve, Hegade, Vinod S., Jones, Rebecca, Rushbrook, Simon, Thorburn, Douglas, Ryder, Steve, Hirschfield, Gideon, Dyson, Jessica K., Jones, David E.J.
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health, Inc 01.12.2021
• Subjects: Aged; Biliary Tract - cytology; Biliary Tract - metabolism; Biomarkers; Biomarkers - blood; Case-Control Studies; CCL20 protein; Chemokines; Chemokines - blood; Cholangitis; Discriminant analysis; Epithelial cells; Epithelial Cells - metabolism; Female; Hepatology; Humans; Inflammation; Ligands; Liver Cirrhosis, Biliary - blood; Liver Cirrhosis, Biliary - drug therapy; Liver Cirrhosis, Biliary - metabolism; Male; Middle Aged; Patients; Proteome; Proteomes; Proteomics; Senescence; Serum levels; Treatment Failure; Ursodeoxycholic acid; Ursodeoxycholic Acid - therapeutic use; United Kingdom > UK

Background and Aims Stratified therapy has entered clinical practice in primary biliary cholangitis (PBC), with routine use of second‐line therapy in nonresponders to first‐line therapy with ursodeoxycholic acid (UDCA). The mechanism for nonresponse to UDCA remains, however, unclear and we lack mech...