Decreased Circulating Levels of Oxytocin in Obesity and Newly Diagnosed Type 2 Diabetic Patients
Context and Objective:Oxytocin can affect energy homeostasis and has interesting potential as a metabolic disease therapeutic. We detected serum oxytocin levels in obese (OB) and type 2 diabetes mellitus (T2DM) subjects and investigated the relationships between serum oxytocin levels and glycolipid...
Saved in:
| Published in | The journal of clinical endocrinology and metabolism Vol. 99; no. 12; pp. 4683 - 4689 |
|---|---|
| Main Authors | , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Bethesda, MD
Oxford University Press
01.12.2014
Copyright by The Endocrine Society Endocrine Society |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0021-972X 1945-7197 1945-7197 |
| DOI | 10.1210/jc.2014-2206 |
Cover
Loading…
| Abstract | Context and Objective:Oxytocin can affect energy homeostasis and has interesting potential as a metabolic disease therapeutic. We detected serum oxytocin levels in obese (OB) and type 2 diabetes mellitus (T2DM) subjects and investigated the relationships between serum oxytocin levels and glycolipid metabolism, insulin resistance, pancreatic β-cell function, and inflammation.Patients and Methods:A total of 176 subjects were enrolled in the study, including 88 patients with newly diagnosed T2DM and 88 subjects with normal glucose tolerance (NGT). NGT and T2DM groups were divided into normal-weight (NW) and OB subgroups. We analyzed the concentrations of oxytocin by ELISA. Oral glucose tolerance testing was done, and hemoglobin A1c (HbA1c), blood lipids, and highly sensitive C-reactive protein (hs-CRP) were also measured. Insulin resistance and pancreatic β-cell function were assessed by homeostasis model assessment (HOMA).Results:Serum oxytocin levels were lower in the T2DM group than in the NGT group (P < .01). The levels of serum oxytocin in OB subjects were also lower than those in NW subjects (P < .01). Serum oxytocin levels were negatively correlated with body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), HbA1c, fasting plasma glucose (FPG), 2-hour plasma glucose, fasting insulin (FINS), 2-h insulin, total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), HOMA of insulin resistance (HOMA-IR), and hs-CRP and positively correlated with HOMA of β-cell function (HOMA-β) (P < .05). Multiple stepwise regression analysis showed that 2-hour plasma glucose, BMI, and TC were associated with serum oxytocin levels (P < .05). Logistic regression analyses demonstrated that serum oxytocin was significantly associated with T2DM (P < .01).Conclusions:Serum oxytocin levels were decreased in T2DM as well as OB subjects. |
|---|---|
| AbstractList | CONTEXT AND OBJECTIVE:Oxytocin can affect energy homeostasis and has interesting potential as a metabolic disease therapeutic. We detected serum oxytocin levels in obese (OB) and type 2 diabetes mellitus (T2DM) subjects and investigated the relationships between serum oxytocin levels and glycolipid metabolism, insulin resistance, pancreatic β-cell function, and inflammation.
PATIENTS AND METHODS:A total of 176 subjects were enrolled in the study, including 88 patients with newly diagnosed T2DM and 88 subjects with normal glucose tolerance (NGT). NGT and T2DM groups were divided into normal-weight (NW) and OB subgroups. We analyzed the concentrations of oxytocin by ELISA. Oral glucose tolerance testing was done, and hemoglobin A1c (HbA1c), blood lipids, and highly sensitive C-reactive protein (hs-CRP) were also measured. Insulin resistance and pancreatic β-cell function were assessed by homeostasis model assessment (HOMA).
RESULTS:Serum oxytocin levels were lower in the T2DM group than in the NGT group (P < .01). The levels of serum oxytocin in OB subjects were also lower than those in NW subjects (P < .01). Serum oxytocin levels were negatively correlated with body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), HbA1c, fasting plasma glucose (FPG), 2-hour plasma glucose, fasting insulin (FINS), 2-h insulin, total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), HOMA of insulin resistance (HOMA-IR), and hs-CRP and positively correlated with HOMA of β-cell function (HOMA-β) (P < .05). Multiple stepwise regression analysis showed that 2-hour plasma glucose, BMI, and TC were associated with serum oxytocin levels (P < .05). Logistic regression analyses demonstrated that serum oxytocin was significantly associated with T2DM (P < .01).
CONCLUSIONS:Serum oxytocin levels were decreased in T2DM as well as OB subjects. Context and Objective:Oxytocin can affect energy homeostasis and has interesting potential as a metabolic disease therapeutic. We detected serum oxytocin levels in obese (OB) and type 2 diabetes mellitus (T2DM) subjects and investigated the relationships between serum oxytocin levels and glycolipid metabolism, insulin resistance, pancreatic β-cell function, and inflammation.Patients and Methods:A total of 176 subjects were enrolled in the study, including 88 patients with newly diagnosed T2DM and 88 subjects with normal glucose tolerance (NGT). NGT and T2DM groups were divided into normal-weight (NW) and OB subgroups. We analyzed the concentrations of oxytocin by ELISA. Oral glucose tolerance testing was done, and hemoglobin A1c (HbA1c), blood lipids, and highly sensitive C-reactive protein (hs-CRP) were also measured. Insulin resistance and pancreatic β-cell function were assessed by homeostasis model assessment (HOMA).Results:Serum oxytocin levels were lower in the T2DM group than in the NGT group (P < .01). The levels of serum oxytocin in OB subjects were also lower than those in NW subjects (P < .01). Serum oxytocin levels were negatively correlated with body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), HbA1c, fasting plasma glucose (FPG), 2-hour plasma glucose, fasting insulin (FINS), 2-h insulin, total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), HOMA of insulin resistance (HOMA-IR), and hs-CRP and positively correlated with HOMA of β-cell function (HOMA-β) (P < .05). Multiple stepwise regression analysis showed that 2-hour plasma glucose, BMI, and TC were associated with serum oxytocin levels (P < .05). Logistic regression analyses demonstrated that serum oxytocin was significantly associated with T2DM (P < .01).Conclusions:Serum oxytocin levels were decreased in T2DM as well as OB subjects. Oxytocin can affect energy homeostasis and has interesting potential as a metabolic disease therapeutic. We detected serum oxytocin levels in obese (OB) and type 2 diabetes mellitus (T2DM) subjects and investigated the relationships between serum oxytocin levels and glycolipid metabolism, insulin resistance, pancreatic β-cell function, and inflammation.CONTEXT AND OBJECTIVEOxytocin can affect energy homeostasis and has interesting potential as a metabolic disease therapeutic. We detected serum oxytocin levels in obese (OB) and type 2 diabetes mellitus (T2DM) subjects and investigated the relationships between serum oxytocin levels and glycolipid metabolism, insulin resistance, pancreatic β-cell function, and inflammation.A total of 176 subjects were enrolled in the study, including 88 patients with newly diagnosed T2DM and 88 subjects with normal glucose tolerance (NGT). NGT and T2DM groups were divided into normal-weight (NW) and OB subgroups. We analyzed the concentrations of oxytocin by ELISA. Oral glucose tolerance testing was done, and hemoglobin A1c (HbA1c), blood lipids, and highly sensitive C-reactive protein (hs-CRP) were also measured. Insulin resistance and pancreatic β-cell function were assessed by homeostasis model assessment (HOMA).PATIENTS AND METHODSA total of 176 subjects were enrolled in the study, including 88 patients with newly diagnosed T2DM and 88 subjects with normal glucose tolerance (NGT). NGT and T2DM groups were divided into normal-weight (NW) and OB subgroups. We analyzed the concentrations of oxytocin by ELISA. Oral glucose tolerance testing was done, and hemoglobin A1c (HbA1c), blood lipids, and highly sensitive C-reactive protein (hs-CRP) were also measured. Insulin resistance and pancreatic β-cell function were assessed by homeostasis model assessment (HOMA).Serum oxytocin levels were lower in the T2DM group than in the NGT group (P < .01). The levels of serum oxytocin in OB subjects were also lower than those in NW subjects (P < .01). Serum oxytocin levels were negatively correlated with body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), HbA1c, fasting plasma glucose (FPG), 2-hour plasma glucose, fasting insulin (FINS), 2-h insulin, total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), HOMA of insulin resistance (HOMA-IR), and hs-CRP and positively correlated with HOMA of β-cell function (HOMA-β) (P < .05). Multiple stepwise regression analysis showed that 2-hour plasma glucose, BMI, and TC were associated with serum oxytocin levels (P < .05). Logistic regression analyses demonstrated that serum oxytocin was significantly associated with T2DM (P < .01).RESULTSSerum oxytocin levels were lower in the T2DM group than in the NGT group (P < .01). The levels of serum oxytocin in OB subjects were also lower than those in NW subjects (P < .01). Serum oxytocin levels were negatively correlated with body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), HbA1c, fasting plasma glucose (FPG), 2-hour plasma glucose, fasting insulin (FINS), 2-h insulin, total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), HOMA of insulin resistance (HOMA-IR), and hs-CRP and positively correlated with HOMA of β-cell function (HOMA-β) (P < .05). Multiple stepwise regression analysis showed that 2-hour plasma glucose, BMI, and TC were associated with serum oxytocin levels (P < .05). Logistic regression analyses demonstrated that serum oxytocin was significantly associated with T2DM (P < .01).Serum oxytocin levels were decreased in T2DM as well as OB subjects.CONCLUSIONSSerum oxytocin levels were decreased in T2DM as well as OB subjects. Oxytocin can affect energy homeostasis and has interesting potential as a metabolic disease therapeutic. We detected serum oxytocin levels in obese (OB) and type 2 diabetes mellitus (T2DM) subjects and investigated the relationships between serum oxytocin levels and glycolipid metabolism, insulin resistance, pancreatic β-cell function, and inflammation. A total of 176 subjects were enrolled in the study, including 88 patients with newly diagnosed T2DM and 88 subjects with normal glucose tolerance (NGT). NGT and T2DM groups were divided into normal-weight (NW) and OB subgroups. We analyzed the concentrations of oxytocin by ELISA. Oral glucose tolerance testing was done, and hemoglobin A1c (HbA1c), blood lipids, and highly sensitive C-reactive protein (hs-CRP) were also measured. Insulin resistance and pancreatic β-cell function were assessed by homeostasis model assessment (HOMA). Serum oxytocin levels were lower in the T2DM group than in the NGT group (P < .01). The levels of serum oxytocin in OB subjects were also lower than those in NW subjects (P < .01). Serum oxytocin levels were negatively correlated with body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), HbA1c, fasting plasma glucose (FPG), 2-hour plasma glucose, fasting insulin (FINS), 2-h insulin, total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), HOMA of insulin resistance (HOMA-IR), and hs-CRP and positively correlated with HOMA of β-cell function (HOMA-β) (P < .05). Multiple stepwise regression analysis showed that 2-hour plasma glucose, BMI, and TC were associated with serum oxytocin levels (P < .05). Logistic regression analyses demonstrated that serum oxytocin was significantly associated with T2DM (P < .01). Serum oxytocin levels were decreased in T2DM as well as OB subjects. |
| Author | Wang, Dong Zhu, Tianyi Mao, Chaoming Pan, Ruirong Yuan, Guoyue Sun, Wenjun Hu, Hao Yu, Shuqin Tang, Bingqian Wang, Jifang Zhou, Libin Yang, Ling Qian, Weiyun |
| AuthorAffiliation | Department of Endocrinology (W.Q., T.Z., B.T., S.Y., H.H., W.S., R.P., J.W., D.W., L.Y., C.M., G.Y.), Affiliated Hospital of Jiangsu University, Jiangsu 212001, China; and Ruijin Hospital (L.Z.), Shanghai Institute of Endocrine and Metabolic Diseases, State Key Laboratory of Medical Genomics, Shanghai Jiaotong University Medical School, Shanghai 200025, China |
| AuthorAffiliation_xml | – name: Department of Endocrinology (W.Q., T.Z., B.T., S.Y., H.H., W.S., R.P., J.W., D.W., L.Y., C.M., G.Y.), Affiliated Hospital of Jiangsu University, Jiangsu 212001, China; and Ruijin Hospital (L.Z.), Shanghai Institute of Endocrine and Metabolic Diseases, State Key Laboratory of Medical Genomics, Shanghai Jiaotong University Medical School, Shanghai 200025, China |
| Author_xml | – sequence: 1 givenname: Weiyun surname: Qian fullname: Qian, Weiyun organization: 1Department of Endocrinology (W.Q., T.Z., B.T., S.Y., H.H., W.S., R.P., J.W., D.W., L.Y., C.M., G.Y.), Affiliated Hospital of Jiangsu University, Jiangsu 212001, China – sequence: 2 givenname: Tianyi surname: Zhu fullname: Zhu, Tianyi organization: 1Department of Endocrinology (W.Q., T.Z., B.T., S.Y., H.H., W.S., R.P., J.W., D.W., L.Y., C.M., G.Y.), Affiliated Hospital of Jiangsu University, Jiangsu 212001, China – sequence: 3 givenname: Bingqian surname: Tang fullname: Tang, Bingqian organization: 1Department of Endocrinology (W.Q., T.Z., B.T., S.Y., H.H., W.S., R.P., J.W., D.W., L.Y., C.M., G.Y.), Affiliated Hospital of Jiangsu University, Jiangsu 212001, China – sequence: 4 givenname: Shuqin surname: Yu fullname: Yu, Shuqin organization: 1Department of Endocrinology (W.Q., T.Z., B.T., S.Y., H.H., W.S., R.P., J.W., D.W., L.Y., C.M., G.Y.), Affiliated Hospital of Jiangsu University, Jiangsu 212001, China – sequence: 5 givenname: Hao surname: Hu fullname: Hu, Hao organization: 1Department of Endocrinology (W.Q., T.Z., B.T., S.Y., H.H., W.S., R.P., J.W., D.W., L.Y., C.M., G.Y.), Affiliated Hospital of Jiangsu University, Jiangsu 212001, China – sequence: 6 givenname: Wenjun surname: Sun fullname: Sun, Wenjun organization: 1Department of Endocrinology (W.Q., T.Z., B.T., S.Y., H.H., W.S., R.P., J.W., D.W., L.Y., C.M., G.Y.), Affiliated Hospital of Jiangsu University, Jiangsu 212001, China – sequence: 7 givenname: Ruirong surname: Pan fullname: Pan, Ruirong organization: 1Department of Endocrinology (W.Q., T.Z., B.T., S.Y., H.H., W.S., R.P., J.W., D.W., L.Y., C.M., G.Y.), Affiliated Hospital of Jiangsu University, Jiangsu 212001, China – sequence: 8 givenname: Jifang surname: Wang fullname: Wang, Jifang organization: 1Department of Endocrinology (W.Q., T.Z., B.T., S.Y., H.H., W.S., R.P., J.W., D.W., L.Y., C.M., G.Y.), Affiliated Hospital of Jiangsu University, Jiangsu 212001, China – sequence: 9 givenname: Dong surname: Wang fullname: Wang, Dong organization: 1Department of Endocrinology (W.Q., T.Z., B.T., S.Y., H.H., W.S., R.P., J.W., D.W., L.Y., C.M., G.Y.), Affiliated Hospital of Jiangsu University, Jiangsu 212001, China – sequence: 10 givenname: Ling surname: Yang fullname: Yang, Ling organization: 1Department of Endocrinology (W.Q., T.Z., B.T., S.Y., H.H., W.S., R.P., J.W., D.W., L.Y., C.M., G.Y.), Affiliated Hospital of Jiangsu University, Jiangsu 212001, China – sequence: 11 givenname: Chaoming surname: Mao fullname: Mao, Chaoming organization: 1Department of Endocrinology (W.Q., T.Z., B.T., S.Y., H.H., W.S., R.P., J.W., D.W., L.Y., C.M., G.Y.), Affiliated Hospital of Jiangsu University, Jiangsu 212001, China – sequence: 12 givenname: Libin surname: Zhou fullname: Zhou, Libin organization: 2Ruijin Hospital (L.Z.), Shanghai Institute of Endocrine and Metabolic Diseases, State Key Laboratory of Medical Genomics, Shanghai Jiaotong University Medical School, Shanghai 200025, China – sequence: 13 givenname: Guoyue surname: Yuan fullname: Yuan, Guoyue email: yuanguoyue@hotmail.com organization: 1Department of Endocrinology (W.Q., T.Z., B.T., S.Y., H.H., W.S., R.P., J.W., D.W., L.Y., C.M., G.Y.), Affiliated Hospital of Jiangsu University, Jiangsu 212001, China |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=29075584$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/25233153$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1kt1rFDEUxYNU7Lb65rMMiOiDU_M5mXmUrV-wuD5U8C1mMnfarNlkm8y4zn9vxl0VCg2BkJvfuRzuyRk68cEDQk8JviCU4Dcbc0Ex4SWluHqAFqThopSkkSdogTElZSPpt1N0ltIGZ4wL9gidUkEZI4It0PdLMBF0gq5Y2mhGpwfrr4sV_ASXitAX61_TEIz1Rd7rFpIdpkL7rvgMezcVl1Zf-zCrr6YdFHQutDBYU3zJjcAP6TF62GuX4MnxPEdf37-7Wn4sV-sPn5ZvV6XhTXbJG9Z3upVtyyTDwnSNbuu-F4zWkkADAhPQkkhdCc77yjStNlSIphP5ueeSnaNXh767GG5HSIPa2mTAOe0hjEmRinEqJREio8_voJswRp_dKUYqzitMcZ2pZ0dqbLfQqV20Wx0n9Xd2GXhxBHQy2vVRe2PTf67BUoiaZ-71gTMxpBSh_4cQrOYI1caoOUI1R5hxegc3dsjDDH6I2rr7RPwg2gc3QEw_3LiHqG5Au-FG4bx4JetyFhCab-VcIVn28iAL4-4-V38-FvsND1q3dQ |
| CODEN | JCEMAZ |
| CitedBy_id | crossref_primary_10_1111_ijpo_12527 crossref_primary_10_1186_s13148_022_01318_3 crossref_primary_10_1210_jc_2018_02608 crossref_primary_10_1016_j_yexmp_2021_104604 crossref_primary_10_1007_s12020_023_03453_0 crossref_primary_10_1186_s12986_024_00828_6 crossref_primary_10_1210_jc_2019_00643 crossref_primary_10_1515_hmbci_2016_0045 crossref_primary_10_1016_j_yhbeh_2021_105005 crossref_primary_10_1186_s40478_023_01606_w crossref_primary_10_1038_s41467_018_07033_z crossref_primary_10_3389_fphys_2021_726411 crossref_primary_10_1038_s41366_021_00876_5 crossref_primary_10_1007_s40519_024_01698_w crossref_primary_10_3390_ijms23158207 crossref_primary_10_1515_enr_2016_0025 crossref_primary_10_2337_db16_0569 crossref_primary_10_1111_dom_15812 crossref_primary_10_1111_jne_13016 crossref_primary_10_1159_000538792 crossref_primary_10_1016_j_tem_2021_02_005 crossref_primary_10_3389_fendo_2015_00119 crossref_primary_10_1007_s00592_016_0926_1 crossref_primary_10_1016_j_dsx_2016_08_008 crossref_primary_10_1016_j_diabres_2016_09_022 crossref_primary_10_1038_s41598_018_20963_4 crossref_primary_10_1016_j_clnu_2021_08_011 crossref_primary_10_1016_j_molmet_2018_08_005 crossref_primary_10_1016_j_peptides_2017_12_019 crossref_primary_10_1111_jne_13243 crossref_primary_10_1111_obr_12757 crossref_primary_10_1038_s41366_018_0150_x crossref_primary_10_1016_j_lfs_2021_119130 crossref_primary_10_1038_s41598_018_28816_w crossref_primary_10_1016_j_yfrne_2016_12_004 crossref_primary_10_1159_000492001 crossref_primary_10_1177_0890334419838225 crossref_primary_10_1002_hbm_23308 crossref_primary_10_1038_s41574_023_00894_5 crossref_primary_10_1111_dom_12928 crossref_primary_10_3390_ijms23084309 crossref_primary_10_1016_j_clinbiochem_2018_10_016 crossref_primary_10_1093_nutrit_nux078 crossref_primary_10_17925_EE_2020_16_1_25 crossref_primary_10_1021_acs_molpharmaceut_5b00047 crossref_primary_10_3389_fnins_2019_00454 crossref_primary_10_1507_endocrj_EJ16_0078 crossref_primary_10_3390_ijms21145144 crossref_primary_10_1016_j_yhbeh_2017_09_005 crossref_primary_10_1038_s41598_017_09318_7 crossref_primary_10_1038_nutd_2017_24 crossref_primary_10_1210_endrev_bnz012 crossref_primary_10_3390_molecules24213887 crossref_primary_10_1038_nrendo_2017_115 crossref_primary_10_3390_nu17050784 crossref_primary_10_1016_j_physbeh_2015_05_023 crossref_primary_10_1152_ajpregu_00220_2015 crossref_primary_10_1210_endrev_bnad033 crossref_primary_10_1038_ijo_2016_149 crossref_primary_10_1056_EVIDoa2300349 crossref_primary_10_3803_EnM_2019_34_3_302 crossref_primary_10_33808_clinexphealthsci_975706 crossref_primary_10_1016_j_peptides_2019_05_001 crossref_primary_10_3389_fimmu_2022_864007 crossref_primary_10_1016_j_physbeh_2017_03_007 crossref_primary_10_1042_CS20170030 crossref_primary_10_1371_journal_pone_0190301 crossref_primary_10_1016_j_biopha_2023_114852 crossref_primary_10_1016_j_peptides_2024_171202 crossref_primary_10_1007_s12020_016_1084_5 crossref_primary_10_1111_jne_12805 crossref_primary_10_7570_jomes20098 crossref_primary_10_3390_ijms24054832 crossref_primary_10_1016_j_archger_2019_103903 crossref_primary_10_1016_j_physbeh_2019_112684 crossref_primary_10_1152_ajpregu_00422_2015 crossref_primary_10_1210_jc_2016_3963 crossref_primary_10_3389_fendo_2024_1387964 crossref_primary_10_1111_cen_13909 crossref_primary_10_1111_dom_13527 crossref_primary_10_1097_MED_0000000000000351 crossref_primary_10_1186_s12902_016_0110_1 crossref_primary_10_3390_ijerph18062923 crossref_primary_10_3390_ijms23137092 crossref_primary_10_1210_endrev_bnab034 crossref_primary_10_4158_EP151192_RA crossref_primary_10_1016_j_bbagen_2020_129811 crossref_primary_10_1016_j_biopsycho_2019_107718 crossref_primary_10_1016_j_neuropharm_2020_108082 crossref_primary_10_3390_ijms22147737 crossref_primary_10_3390_ijms222111784 crossref_primary_10_1016_j_jogn_2023_11_003 crossref_primary_10_3389_fpsyt_2019_01032 crossref_primary_10_1113_EP090513 crossref_primary_10_1177_2042018818788802 crossref_primary_10_3390_nu15030535 crossref_primary_10_1016_j_neuropharm_2024_110201 |
| ContentType | Journal Article |
| Copyright | Copyright © 2014 by the Endocrine Society 2014 Copyright © 2014 by The Endocrine Society 2015 INIST-CNRS Copyright © 2014 by the Endocrine Society |
| Copyright_xml | – notice: Copyright © 2014 by the Endocrine Society 2014 – notice: Copyright © 2014 by The Endocrine Society – notice: 2015 INIST-CNRS – notice: Copyright © 2014 by the Endocrine Society |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7QP 7T5 7TM H94 K9. 7X8 |
| DOI | 10.1210/jc.2014-2206 |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Calcium & Calcified Tissue Abstracts Immunology Abstracts Nucleic Acids Abstracts AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Immunology Abstracts Calcium & Calcified Tissue Abstracts Nucleic Acids Abstracts MEDLINE - Academic |
| DatabaseTitleList | AIDS and Cancer Research Abstracts MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1945-7197 |
| EndPage | 4689 |
| ExternalDocumentID | 25233153 29075584 10_1210_jc_2014_2206 00004678-201412000-00041 10.1210/jc.2014-2206 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- -~X .55 .XZ 08P 0R~ 18M 1TH 29K 2WC 34G 354 39C 4.4 48X 53G 5GY 5RS 5YH 8F7 AABZA AACZT AAIMJ AAPQZ AAPXW AARHZ AAUAY AAVAP AAWTL ABBLC ABDFA ABEJV ABGNP ABJNI ABLJU ABMNT ABNHQ ABOCM ABPMR ABPPZ ABPQP ABPTD ABQNK ABVGC ABWST ABXVV ACGFO ACGFS ACPRK ACUTJ ACYHN ADBBV ADGKP ADGZP ADHKW ADQBN ADRTK ADVEK AELWJ AEMDU AENEX AENZO AETBJ AEWNT AFCHL AFFZL AFGWE AFOFC AFRAH AFXAL AGINJ AGKRT AGQXC AGUTN AHMBA AHMMS AJEEA ALMA_UNASSIGNED_HOLDINGS APIBT ARIXL ASPBG ATGXG AVWKF AZFZN BAWUL BAYMD BCRHZ BEYMZ BSWAC BTRTY C45 CDBKE CS3 D-I DAKXR DIK E3Z EBS EJD EMOBN ENERS F5P FECEO FHSFR FLUFQ FOEOM FOTVD FQBLK GAUVT GJXCC GX1 H13 HZ~ H~9 KBUDW KOP KQ8 KSI KSN L7B M5~ MHKGH MJL N9A NLBLG NOMLY NOYVH NVLIB O9- OAUYM OBH OCB ODMLO OFXIZ OGEVE OHH OJZSN OK1 OPAEJ OVD OVIDX P2P P6G REU ROX ROZ TEORI TJX TLC TR2 TWZ VVN W8F WOQ X7M YBU YFH YHG YOC YSK ZY1 ~02 ~H1 .GJ 3O- 7X7 88E 8FI 8FJ AAJQQ AAKAS AAPGJ AAQQT AAUQX AAWDT AAYJJ ABDPE ABUWG ABXZS ACFRR ACVCV ACZBC ADMTO ADNBA ADZCM AEMQT AEOTA AERZD AFFNX AFFQV AFKRA AFYAG AGMDO AGORE AHGBF AI. AJBYB AJDVS ALXQX APJGH AQDSO AQKUS AVNTJ BENPR BPHCQ BVXVI CCPQU EIHJH FEDTE FYUFA HMCUK HVGLF IAO IHR INH ITC J5H M1P MBLQV N4W NU- OBFPC PHGZM PHGZT PQQKQ PROAC PSQYO TMA UKHRP VH1 WHG X52 ZGI ZXP AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM PJZUB PPXIY 7QP 7T5 7TM H94 K9. 7X8 |
| ID | FETCH-LOGICAL-c4921-493fdab7bb37305cd9ab8ff532871e9e501ea717a6544f6c9bac2559d571ef473 |
| ISSN | 0021-972X 1945-7197 |
| IngestDate | Mon Jul 21 10:29:52 EDT 2025 Mon Jun 30 12:44:15 EDT 2025 Mon Jul 21 06:04:40 EDT 2025 Wed Apr 02 07:14:00 EDT 2025 Tue Jul 01 01:10:33 EDT 2025 Thu Apr 24 23:09:10 EDT 2025 Fri May 16 03:43:24 EDT 2025 Fri Feb 07 10:35:39 EST 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 12 |
| Keywords | Endocrinopathy Type 2 diabetes Human Obesity Nutrition Oxytocin Nutrition disorder Patient Metabolic diseases Early stage Endocrinology Nutritional status |
| Language | English |
| License | CC BY 4.0 |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c4921-493fdab7bb37305cd9ab8ff532871e9e501ea717a6544f6c9bac2559d571ef473 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| PMID | 25233153 |
| PQID | 3164460208 |
| PQPubID | 2046206 |
| PageCount | 7 |
| ParticipantIDs | proquest_miscellaneous_1634277155 proquest_journals_3164460208 pubmed_primary_25233153 pascalfrancis_primary_29075584 crossref_primary_10_1210_jc_2014_2206 crossref_citationtrail_10_1210_jc_2014_2206 wolterskluwer_health_00004678-201412000-00041 oup_primary_10_1210_jc_2014-2206 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2014-December |
| PublicationDateYYYYMMDD | 2014-12-01 |
| PublicationDate_xml | – month: 12 year: 2014 text: 2014-December |
| PublicationDecade | 2010 |
| PublicationPlace | Bethesda, MD |
| PublicationPlace_xml | – name: Bethesda, MD – name: United States – name: Washington |
| PublicationTitle | The journal of clinical endocrinology and metabolism |
| PublicationTitleAlternate | J Clin Endocrinol Metab |
| PublicationYear | 2014 |
| Publisher | Oxford University Press Copyright by The Endocrine Society Endocrine Society |
| Publisher_xml | – name: Oxford University Press – name: Copyright by The Endocrine Society – name: Endocrine Society |
| SSID | ssj0014453 |
| Score | 2.4901273 |
| Snippet | Context and Objective:Oxytocin can affect energy homeostasis and has interesting potential as a metabolic disease therapeutic. We detected serum oxytocin... CONTEXT AND OBJECTIVE:Oxytocin can affect energy homeostasis and has interesting potential as a metabolic disease therapeutic. We detected serum oxytocin... Oxytocin can affect energy homeostasis and has interesting potential as a metabolic disease therapeutic. We detected serum oxytocin levels in obese (OB) and... |
| SourceID | proquest pubmed pascalfrancis crossref wolterskluwer oup |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 4683 |
| SubjectTerms | Adiposity Adult Aged Beta cells Biological and medical sciences Body mass index C-reactive protein C-Reactive Protein - metabolism Cholesterol Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - blood Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Energy balance Etiopathogenesis. Screening. Investigations. Target tissue resistance Fasting Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Glucose Glucose tolerance Glycated Hemoglobin A - analysis Glycolipids - metabolism Hemoglobin Homeostasis Hormones Humans Insulin resistance Insulin Resistance - physiology Insulin-Secreting Cells - pathology Laboratory testing Lipids Low density lipoprotein Male Medical sciences Metabolic disorders Middle Aged Obesity Obesity - blood Oxytocin Oxytocin - blood Pancreas Pancreatic Function Tests Triglycerides Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology |
| Title | Decreased Circulating Levels of Oxytocin in Obesity and Newly Diagnosed Type 2 Diabetic Patients |
| URI | https://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00004678-201412000-00041 https://www.ncbi.nlm.nih.gov/pubmed/25233153 https://www.proquest.com/docview/3164460208 https://www.proquest.com/docview/1634277155 |
| Volume | 99 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELfKkBASQnwTGJOR4AllamInaR752JjQGA-0ovBiEsfWCiXplkZQ_nru7MRNRScNpCqqkquT5vfL5c6-D0KeDZXisebSZzzPfaxu4mdxEfghU0xzNsKiaRhtcRIfTfi7aTQdDBa9qKVmme_L31vzSv4HVdgHuGKW7D8g6waFHfAd8IUtIAzbS2H8xth8NdiMcnYuTSMucPznGAdkIjSqX6sl3HwTzFjZDgBmsQBM6fkKp10xyg5-vTEPO5NdsdW6b7kin3plJlxGpSqLCjRPua7l9EMtgVnzrjYhzqrO7DTrJzVbNY6NX04byxbQR7P1DIJVPq_gn5z1qPvZyH48bc7aUuHtTEXAe1EfVrmmPPKTwMbj7qst-1qNbFsmdcwLe_qVx7btzV-KHzxXVPxYlBJOHIbDLfW1Tz6Iw8nxsRgfTMdXyNUwSczC_tupCwoC79LULXVX1aZKYJ5Tf-wNI8YmRt5YZDXcdW3boWzzV0DmZ4UhEPV3kwHRs2PGt8jN1gGhLy2bbpOBKu-Qa-_bEIu75KsjFe2RilpS0UrTjlQUPi2pKMBODamoIxVFUtGQdqSiHanukcnhwfj1kd-24fAlT8PA5ynTRZYnec7gdRDJIs3ykdYRQ2dbpSoaBipLgiSLI851LNM8k-ioFhEc1jxh98lOWZXqIaFa47IvWKSxYhz7QWo1LEZ6xEZMRWEReORFd1-FbGvUY6uUuUBfFVAQ36RAFASi4JHnTnpha7NcIEcBootEfCuyt4GfEw5TsKnBSPfIbgeoaB-2WrAAvIkY29x65Kk7DPoZF92yUlVNLcDf4ci0KPLIA0uE9eBRyBiYHB7xN5ghbA60MA48WJM-XmfgikAEjy5xtsfk-voZ3CU7y_NGPQH7eZnvGcr_AT6Sw-Q |
| linkProvider | Geneva Foundation for Medical Education and Research |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Decreased+circulating+levels+of+oxytocin+in+obesity+and+newly+diagnosed+type+2+diabetic+patients&rft.jtitle=The+journal+of+clinical+endocrinology+and+metabolism&rft.au=Qian%2C+Weiyun&rft.au=Zhu%2C+Tianyi&rft.au=Tang%2C+Bingqian&rft.au=Yu%2C+Shuqin&rft.date=2014-12-01&rft.issn=1945-7197&rft.eissn=1945-7197&rft.volume=99&rft.issue=12&rft.spage=4683&rft_id=info:doi/10.1210%2Fjc.2014-2206&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-972X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-972X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-972X&client=summon |