Damage and threshold shift resulting from cochlear exposure to Paraquat-generated superoxide

• Published in: Hearing research Vol. 207; no. 1; pp. 35 - 42
• Main Authors: Bielefeld, Eric C., Hu, Bo Hua, Harris, Kelly Carney, Henderson, Donald
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.09.2005; Elsevier
• Subjects: Animals; Auditory Threshold - drug effects; Biological and medical sciences; Chinchilla; Cochlea; Cochlea - drug effects; Cochlea - pathology; Cochlea - physiopathology; Dose-Response Relationship, Drug; Drug toxicity and drugs side effects treatment; Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology; Evoked Potentials, Auditory - drug effects; Hair Cells, Auditory, Inner - drug effects; Hair Cells, Auditory, Inner - pathology; Hair Cells, Auditory, Outer - drug effects; Hair Cells, Auditory, Outer - pathology; Hearing Loss - chemically induced; Hearing Loss - pathology; Hearing Loss - physiopathology; Herbicides - administration & dosage; Herbicides - toxicity; Medical sciences; NADPH oxidase; NADPH Oxidases - metabolism; Non tumoral diseases; Otorhinolaryngology. Stomatology; Paraquat; Paraquat - administration & dosage; Paraquat - toxicity; Pharmacology. Drug treatments; Superoxide; Superoxides - metabolism; Superoxides - toxicity; Toxicity: respiratory system, ent, stomatology; PBS; PQ; IHC; TDT; SOD; Superoxide; OHC; PTS; TTS; NADPH oxidase; ROS; Cochlea; Paraquat; IC; EVP; Noise; Central nervous system; Electrophysiology; Auditory disorder; Recovery; Inner ear; Outer hair cell; Chinchilla; Organ of hearing; Encephalon; ENT disease; Drug; Hair cell of the ear; Oxygen; Implant; Rodentia; Hearing loss; Vertebrata; Mammalia; Round window; Colliculus inferior; Evoked potential; Threshold shift; Auditory pathway; Superoxide: NADPH oxidase

Superoxide has been implicated as a contributing factor to cochlear pathology from a number of sources, including noise and ototoxic drugs. The effects of NADPH oxidase-dependent superoxide on the cochlea were investigated in the current study using paraquat (PQ). PQ is a toxic herbicide that causes...