MUTYH Gene Polymorphisms as Risk Factors for Rheumatoid Arthritis

• Published in: BioMed research international Vol. 2015; no. 2015; pp. 1 - 8
• Main Authors: Wan, Lei, Huang, Yong-San, Hsu, Yu-An, Chen, Ter-Hsin, Lin, Hui-Ju, Huang, Chung-Ming, Tsai, Kun Shi, Kung, Yung-Jen, Chang, Ching-Yao
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2015; John Wiley & Sons, Inc
• Subjects: Arthritis, Rheumatoid - diagnosis; Arthritis, Rheumatoid - epidemiology; Arthritis, Rheumatoid - genetics; Base Sequence; Cancer; Deoxyribonucleic acid; Disease; DNA; DNA Glycosylases - genetics; DNA repair; Enzymes; Female; Genes; Genetic Markers - genetics; Genetic polymorphisms; Genetic Predisposition to Disease - epidemiology; Genetic Predisposition to Disease - genetics; Genotype & phenotype; Haplotypes; Haplotypes - genetics; Hospitals; Humans; Incidence; Inflammation; Male; Middle Aged; Molecular Sequence Data; Mutation; Physiological aspects; Polymorphism, Single Nucleotide - genetics; Population; Reproducibility of Results; Rheumatoid arthritis; Rheumatology; Risk Factors; Sensitivity and Specificity; Taiwan - epidemiology; Veterinary medicine; Taiwan; China

Objectives. MUTYH glycosylase involved in DNA repair pathways may be associated with the risk of autoimmune diseases such as rheumatoid arthritis (RA). Therefore, the association between polymorphisms in the MUTYH gene and RA was evaluated. Methods. We recruited 192 RA patients and 192 healthy subje...