Environmental control of cell size at division

Tight coupling between cell growth and cell cycle progression allows cells to adjust their size to the demands of proliferation in varying nutrient environments. Target of rapamycin (TOR) signalling pathways co-ordinate cell growth with cell cycle progression in response to altered nutritional avail...

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Bibliographic Details
Published inCurrent opinion in cell biology Vol. 24; no. 6; pp. 838 - 844
Main Authors Davie, Elizabeth, Petersen, Janni
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.12.2012
Subjects
Cell Division
cell growth
Cell Size
Internal Medicine
Mechanistic Target of Rapamycin Complex 1
mitosis
Multiprotein Complexes - metabolism
nutrient availability
nutrients
physiology
Signal Transduction
TOR Serine-Threonine Kinases - metabolism
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Summary:Tight coupling between cell growth and cell cycle progression allows cells to adjust their size to the demands of proliferation in varying nutrient environments. Target of rapamycin (TOR) signalling pathways co-ordinate cell growth with cell cycle progression in response to altered nutritional availability. To increase cell size the active TOR Complex 1 (TORC1) promotes cell growth to delay mitosis and cell division, whereas under limited nutrients TORC1 activity is decreased to reduce cell size. It remains unclear why cell size is subject to such tight control. Recent evidence suggests that in addition to modulating cell size, changes in nutrient availability also alter nuclear:cytoplasmic (N/C) ratios and may therefore compromise optimal cellular physiology. This could explain why cells increase their size when conditions are favourable, despite being competent to survive at a smaller size if necessary.
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ISSN:0955-0674
1879-0410
1879-0410
DOI:10.1016/j.ceb.2012.08.003