Ubiquitin carboxyl-terminal hydrolase L-1 in brain: Focus on its oxidative/nitrosative modification and role in brains of subjects with Alzheimer disease and mild cognitive impairment

• Published in: Free radical biology & medicine Vol. 177; pp. 278 - 286
• Main Author: Butterfield, D. Allan
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2021
• Subjects: Alzheimer Disease - genetics; Alzheimer disease and mild cognitive impairment; Brain - metabolism; Cognitive Dysfunction - genetics; Humans; Loss of function; Neuronal death; Oxidative and nitrosative stress; Oxidative Stress; Ubiquitin - metabolism; Ubiquitin carboxyl-terminal hydrolase-L1; Ubiquitin Thiolesterase - genetics; Ubiquitin Thiolesterase - metabolism; Ubiquitin-proteasomal system; Ubiquitin-proteasomal system; Loss of function; Neuronal death; Oxidative and nitrosative stress; Alzheimer disease and mild cognitive impairment; Ubiquitin carboxyl-terminal hydrolase-L1

Neurons must remove aggregated, damaged proteins in order to survive. Among the ways of facilitating this protein quality control is the ubiquitin-proteasomal system (UPS). Aggregated, damaged proteins are targeted for destruction by the UPS by acquiring a polymer of ubiquitin residues that serves a...