Comparative Analysis of Microbiological Profiles and Antibiotic Resistance Genes in Subjects with Colorectal Cancer and Healthy Individuals

• Published in: Polish journal of microbiology Vol. 74; no. 1; pp. 71 - 81
• Main Authors: Li, Jun, Zhu, Yanyun, Chang, Qing, Gong, Yuan, Wan, Jun, Xu, Shiping
• Format: Journal Article
• Language: English
• Published: Poland Sciendo 01.03.2025; De Gruyter Poland
• Subjects: Actinobacteria; Aged; Anti-Bacterial Agents - pharmacology; Antibiotic resistance; antibiotic resistant genes; Antibiotics; Bacteria - classification; Bacteria - drug effects; Bacteria - genetics; Bacteria - isolation & purification; Cancer; Case-Control Studies; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - microbiology; Comparative analysis; Drug Resistance, Bacterial - genetics; Drug Resistance, Microbial - genetics; Enterobacter cloacae; Feces; Feces - microbiology; Female; Gastrointestinal Microbiome - genetics; Genera; Genes; gut microbiota; Humans; Intestinal microflora; Male; Metabolism; Metagenomics; Microbiomes; Microbiota; Microorganisms; Middle Aged; Next-generation sequencing; Nostoc; Original Paper; Principal components analysis; Risk assessment; Salmonella; Actinobacteria; antibiotic resistant genes; colorectal cancer; metagenomics; gut microbiota

Alteration of the gut microbiota (GM) is associated with various diseases, including colorectal cancer (CRC). With the development of next-generation sequencing techniques, metagenomic sequencing, along with metabolic function and antibiotic-resistant gene analyses, has been used to investigate diff...