Decreased H3K27 and H3K4 trimethylation on mortal chromosomes in distributed stem cells

The role of immortal DNA strands that co-segregate during mitosis of asymmetrically self-renewing distributed stem cells (DSCs) is unknown. Previously, investigation of immortal DNA strand function and molecular mechanisms responsible for their nonrandom co-segregation was precluded by difficulty in...

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Published inCell death & disease Vol. 5; no. 12; p. e1554
Main Authors Huh, Y H, Sherley, J L
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.12.2014
Springer Nature B.V
Nature Publishing Group
Subjects
13
13/1
13/100
13/51
14
14/63
631/208/176/1988
631/532
692/53
Animals
Antibodies
Biochemistry
Biomarkers - metabolism
Biomedical and Life Sciences
Cell Biology
Cell Culture
Cell Differentiation
Cell Lineage - genetics
Chromosome Segregation - genetics
Chromosomes - chemistry
Chromosomes - metabolism
DNA - genetics
DNA - metabolism
DNA Methylation
Epigenesis, Genetic
Hair Follicle - cytology
Hair Follicle - metabolism
Histones - genetics
Histones - metabolism
Immunology
Life Sciences
Mice
Mitosis
Original
original-article
Stem Cells - cytology
Stem Cells - metabolism
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Abstract The role of immortal DNA strands that co-segregate during mitosis of asymmetrically self-renewing distributed stem cells (DSCs) is unknown. Previously, investigation of immortal DNA strand function and molecular mechanisms responsible for their nonrandom co-segregation was precluded by difficulty in identifying DSCs and immortal DNA strands. Here, we report the use of two technological innovations, selective DSC expansion and establishment of H2A.Z chromosomal asymmetry as a specific marker of ‘immortal chromosomes,’ to investigate molecular properties of immortal chromosomes and opposing ‘mortal chromosomes’ in cultured mouse hair follicle DSCs. Although detection of the respective suppressive and activating H3K27me3 and H3K4me3 epigenetic marks on immortal chromosomes was similar to randomly segregated chromosomes, detection of both was lower on mortal chromosomes destined for lineage-committed sister cells. This global epigenomic feature of nonrandom co-segregation may reveal a mechanism that maintains an epigenome-wide ‘poised’ transcription state, which preserves DSC identity, while simultaneously activating sister chromosomes for differentiation.
AbstractList The role of immortal DNA strands that co-segregate during mitosis of asymmetrically self-renewing distributed stem cells (DSCs) is unknown. Previously, investigation of immortal DNA strand function and molecular mechanisms responsible for their nonrandom co-segregation was precluded by difficulty in identifying DSCs and immortal DNA strands. Here, we report the use of two technological innovations, selective DSC expansion and establishment of H2A.Z chromosomal asymmetry as a specific marker of 'immortal chromosomes,' to investigate molecular properties of immortal chromosomes and opposing 'mortal chromosomes' in cultured mouse hair follicle DSCs. Although detection of the respective suppressive and activating H3K27me3 and H3K4me3 epigenetic marks on immortal chromosomes was similar to randomly segregated chromosomes, detection of both was lower on mortal chromosomes destined for lineage-committed sister cells. This global epigenomic feature of nonrandom co-segregation may reveal a mechanism that maintains an epigenome-wide 'poised' transcription state, which preserves DSC identity, while simultaneously activating sister chromosomes for differentiation.
Abstract The role of immortal DNA strands that co-segregate during mitosis of asymmetrically self-renewing distributed stem cells (DSCs) is unknown. Previously, investigation of immortal DNA strand function and molecular mechanisms responsible for their nonrandom co-segregation was precluded by difficulty in identifying DSCs and immortal DNA strands. Here, we report the use of two technological innovations, selective DSC expansion and establishment of H2A.Z chromosomal asymmetry as a specific marker of ‘immortal chromosomes,’ to investigate molecular properties of immortal chromosomes and opposing ‘mortal chromosomes’ in cultured mouse hair follicle DSCs. Although detection of the respective suppressive and activating H3K27me3 and H3K4me3 epigenetic marks on immortal chromosomes was similar to randomly segregated chromosomes, detection of both was lower on mortal chromosomes destined for lineage-committed sister cells. This global epigenomic feature of nonrandom co-segregation may reveal a mechanism that maintains an epigenome-wide ‘poised’ transcription state, which preserves DSC identity, while simultaneously activating sister chromosomes for differentiation.
Author Sherley, J L
Huh, Y H
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SSID ssj0000330256
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Snippet The role of immortal DNA strands that co-segregate during mitosis of asymmetrically self-renewing distributed stem cells (DSCs) is unknown. Previously,...
Abstract The role of immortal DNA strands that co-segregate during mitosis of asymmetrically self-renewing distributed stem cells (DSCs) is unknown....
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StartPage e1554
SubjectTerms 13
13/1
13/100
13/51
14
14/63
631/208/176/1988
631/532
692/53
Animals
Antibodies
Biochemistry
Biomarkers - metabolism
Biomedical and Life Sciences
Cell Biology
Cell Culture
Cell Differentiation
Cell Lineage - genetics
Chromosome Segregation - genetics
Chromosomes - chemistry
Chromosomes - metabolism
DNA - genetics
DNA - metabolism
DNA Methylation
Epigenesis, Genetic
Hair Follicle - cytology
Hair Follicle - metabolism
Histones - genetics
Histones - metabolism
Immunology
Life Sciences
Mice
Mitosis
Original
original-article
Stem Cells - cytology
Stem Cells - metabolism
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Title Decreased H3K27 and H3K4 trimethylation on mortal chromosomes in distributed stem cells
URI https://link.springer.com/article/10.1038/cddis.2014.522
https://www.ncbi.nlm.nih.gov/pubmed/25476902
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https://search.proquest.com/docview/1634274960
https://search.proquest.com/docview/1790941648
https://pubmed.ncbi.nlm.nih.gov/PMC4649838
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