Cluster Analysis and Clinical Asthma Phenotypes

• Published in: American journal of respiratory and critical care medicine Vol. 178; no. 3; pp. 218 - 224
• Main Authors: Haldar, Pranab, Pavord, Ian D, Shaw, Dominic E, Berry, Michael A, Thomas, Michael, Brightling, Christopher E, Wardlaw, Andrew J, Green, Ruth H
• Format: Journal Article
• Language: English
• Published: New York, NY Am Thoracic Soc 01.08.2008; American Lung Association; American Thoracic Society
• Subjects: Adrenal Cortex Hormones - therapeutic use; Adult; Aged; Algorithms; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Asthma; Asthma - classification; Asthma - drug therapy; Asthma - physiopathology; Biological and medical sciences; Chronic obstructive pulmonary disease, asthma; Classification; Cluster Analysis; Datasets; Family physicians; Female; Humans; Inflammation; Inflammation - physiopathology; Intensive care medicine; Male; Medical sciences; Middle Aged; Phenotype; Pneumology; Primary care; Prospective Studies; Steroids; Taxonomy; Lung disease; Corticosteroid; Intensive care; Respiratory disease; corticosteroid response; taxonomy; Asthma; Phenotype; Classification; Bronchus disease; Obstructive pulmonary disease; multivariate classification; Resuscitation

Heterogeneity in asthma expression is multidimensional, including variability in clinical, physiologic, and pathologic parameters. Classification requires consideration of these disparate domains in a unified model. To explore the application of a multivariate mathematical technique, k-means cluster...