The T allele of TCF7L2 rs7903146 is associated with decreased glucose tolerance after bed rest in healthy older adults

• Published in: Scientific reports Vol. 12; no. 1; pp. 6897 - 8
• Main Authors: Fry, Jean L., Munson, Brooke D., Thompson, Katherine L., Fry, Christopher S., Paddon-Jones, Douglas, Arentson-Lantz, Emily J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 27.04.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 631/208/205; 692/163; 692/163/2743/2037; 692/163/2743/2815; 692/308/2056; 692/308/575; 692/499; 692/53/2423; Aged; Alleles; Bed Rest - adverse effects; Blood; Blood glucose; Blood Glucose - metabolism; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - genetics; Genetic diversity; Genetic variance; Glucose; Glucose metabolism; Glucose tolerance; Glucose Tolerance Test; Humanities and Social Sciences; Humans; Hyperglycemia; Immobilization; Insulin; Morbidity; multidisciplinary; Older people; Science; Science (multidisciplinary); Transcription Factor 7-Like 2 Protein - genetics

Inpatient populations are at increased risk of hyperglycemia due to factors such as medications, physical inactivity and underlying illness, which increases morbidity and mortality. Unfortunately, clinicians have limited tools available to prospectively identify those at greatest risk. We evaluated...