Chemokines and the immune response to cancer

Chemokines are chemotactic cytokines that regulate the migration of immune cells. Chemokines function as cues for the coordinated recruitment of immune cells into and out of tissue and also guide the spatial organization and cellular interactions of immune cells within tissues. Chemokines are critic...

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Published inImmunity (Cambridge, Mass.) Vol. 54; no. 5; pp. 859 - 874
Main Authors Ozga, Aleksandra J., Chow, Melvyn T., Luster, Andrew D.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 11.05.2021
Elsevier Limited
Subjects
Animals
Anticancer properties
Bone marrow
Cancer
Cancer therapies
Carcinogenesis - immunology
Cell migration
Cell Movement - immunology
Chemokines
Chemokines - immunology
Cytokines
Genotype & phenotype
Humans
Immune response
Immune system
Immunity - immunology
Immunotherapy
Ligands
Localization
Lymphocytes
Neoplasms - immunology
Regulation
Tumor microenvironment
Tumor Microenvironment - immunology
Tumorigenesis
Tumors
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Abstract Chemokines are chemotactic cytokines that regulate the migration of immune cells. Chemokines function as cues for the coordinated recruitment of immune cells into and out of tissue and also guide the spatial organization and cellular interactions of immune cells within tissues. Chemokines are critical in directing immune cell migration necessary to mount and then deliver an effective anti-tumor immune response; however, chemokines also participate in the generation and recruitment of immune cells that contribute to a pro-tumorigenic microenvironment. Here, we review the role of the chemokine system in anti-tumor and pro-tumor immune responses and discuss how malignant cells and the tumor microenvironment regulate the overall chemokine landscape to shape the type and outcome of immune responses to cancer and cancer treatment. Luster and colleagues review the role of the chemokine system in anti-tumor and pro-tumor immune responses and discuss how malignant cells and the tumor microenvironment regulate the overall chemokine landscape to shape the type and outcome of immune responses to cancer and cancer treatment.
AbstractList SummaryChemokines are chemotactic cytokines that regulate the migration of immune cells. Chemokines function as cues for the coordinated recruitment of immune cells into and out of tissue and also guide the spatial organization and cellular interactions of immune cells within tissues. Chemokines are critical in directing immune cell migration necessary to mount and then deliver an effective anti-tumor immune response; however, chemokines also participate in the generation and recruitment of immune cells that contribute to a pro-tumorigenic microenvironment. Here, we review the role of the chemokine system in anti-tumor and pro-tumor immune responses and discuss how malignant cells and the tumor microenvironment regulate the overall chemokine landscape to shape the type and outcome of immune responses to cancer and cancer treatment.
Chemokines are chemotactic cytokines that regulate the migration of immune cells. Chemokines function as cues for the coordinated recruitment of immune cells into and out of tissue and also guide the spatial organization and cellular interactions of immune cells within tissues. Chemokines are critical in directing immune cell migration necessary to mount and then deliver an effective anti-tumor immune response; however, chemokines also participate in the generation and recruitment of immune cells that contribute to a pro-tumorigenic microenvironment. Here, we review the role of the chemokine system in anti-tumor and pro-tumor immune responses and discuss how malignant cells and the tumor microenvironment regulate the overall chemokine landscape to shape the type and outcome of immune responses to cancer and cancer treatment.
Chemokines are chemotactic cytokines that regulate the migration of immune cells. Chemokines function as cues for the coordinated recruitment of immune cells into and out of tissue and also guide the spatial organization and cellular interactions of immune cells within tissues. Chemokines are critical in directing immune cell migration necessary to mount and then deliver an effective anti-tumor immune response; however, chemokines also participate in the generation and recruitment of immune cells that contribute to a pro-tumorigenic microenvironment. Here, we review the role of the chemokine system in anti-tumor and pro-tumor immune responses and discuss how malignant cells and the tumor microenvironment regulate the overall chemokine landscape to shape the type and outcome of immune responses to cancer and cancer treatment.Chemokines are chemotactic cytokines that regulate the migration of immune cells. Chemokines function as cues for the coordinated recruitment of immune cells into and out of tissue and also guide the spatial organization and cellular interactions of immune cells within tissues. Chemokines are critical in directing immune cell migration necessary to mount and then deliver an effective anti-tumor immune response; however, chemokines also participate in the generation and recruitment of immune cells that contribute to a pro-tumorigenic microenvironment. Here, we review the role of the chemokine system in anti-tumor and pro-tumor immune responses and discuss how malignant cells and the tumor microenvironment regulate the overall chemokine landscape to shape the type and outcome of immune responses to cancer and cancer treatment.
Chemokines are chemotactic cytokines that regulate the migration of immune cells. Chemokines function as cues for the coordinated recruitment of immune cells into and out of tissue and also guide the spatial organization and cellular interactions of immune cells within tissues. Chemokines are critical in directing immune cell migration necessary to mount and then deliver an effective anti-tumor immune response; however, chemokines also participate in the generation and recruitment of immune cells that contribute to a pro-tumorigenic microenvironment. Here, we review the role of the chemokine system in anti-tumor and pro-tumor immune responses and discuss how malignant cells and the tumor microenvironment regulate the overall chemokine landscape to shape the type and outcome of immune responses to cancer and cancer treatment. Luster and colleagues review the role of the chemokine system in anti-tumor and pro-tumor immune responses and discuss how malignant cells and the tumor microenvironment regulate the overall chemokine landscape to shape the type and outcome of immune responses to cancer and cancer treatment.
Author Ozga, Aleksandra J.
Chow, Melvyn T.
Luster, Andrew D.
Author_xml – sequence: 1
  givenname: Aleksandra J.
  surname: Ozga
  fullname: Ozga, Aleksandra J.
  organization: Center for Immunology & Inflammatory Diseases, Division of Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
– sequence: 2
  givenname: Melvyn T.
  surname: Chow
  fullname: Chow, Melvyn T.
  organization: Center for Immunology & Inflammatory Diseases, Division of Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
– sequence: 3
  givenname: Andrew D.
  surname: Luster
  fullname: Luster, Andrew D.
  email: aluster@mgh.harvard.edu
  organization: Center for Immunology & Inflammatory Diseases, Division of Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33838745$$D View this record in MEDLINE/PubMed
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  doi: 10.1007/s00262-013-1506-7
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Snippet Chemokines are chemotactic cytokines that regulate the migration of immune cells. Chemokines function as cues for the coordinated recruitment of immune cells...
SummaryChemokines are chemotactic cytokines that regulate the migration of immune cells. Chemokines function as cues for the coordinated recruitment of immune...
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SubjectTerms Animals
Anticancer properties
Bone marrow
Cancer
Cancer therapies
Carcinogenesis - immunology
Cell migration
Cell Movement - immunology
Chemokines
Chemokines - immunology
Cytokines
Genotype & phenotype
Humans
Immune response
Immune system
Immunity - immunology
Immunotherapy
Ligands
Localization
Lymphocytes
Neoplasms - immunology
Regulation
Tumor microenvironment
Tumor Microenvironment - immunology
Tumorigenesis
Tumors
Title Chemokines and the immune response to cancer
URI https://dx.doi.org/10.1016/j.immuni.2021.01.012
https://www.ncbi.nlm.nih.gov/pubmed/33838745
https://www.proquest.com/docview/2525630744
https://www.proquest.com/docview/2511894973
https://pubmed.ncbi.nlm.nih.gov/PMC8434759
Volume 54
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