Hypoxia modulates CCR7 expression in head and neck cancers

• Published in: Oral oncology Vol. 80; pp. 64 - 73
• Main Authors: Basheer, Haneen A., Pakanavicius, Edvinas, Cooper, Patricia A., Shnyder, Steven D., Martin, Lisette, Hunter, Keith D., Vinader, Victoria, Afarinkia, Kamyar
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.05.2018
• Subjects: Animals; Biomarkers, Tumor - metabolism; CCR7; Cell Hypoxia - genetics; Cell Line, Tumor; Female; Head and neck cancer; Head and Neck Neoplasms - genetics; Head and Neck Neoplasms - pathology; HIF-1α; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Mice; Mice, Inbred BALB C; Mice, Nude; Receptors, CCR7 - genetics; Receptors, CCR7 - metabolism; Tumour grade; Tumour stage; LN; APES; HIF; Tumour stage; DAPI; TMA; HIF-1α; LDH-A; Head and neck cancer; Hypoxia; CCR7; Tumour grade; HNC

•Under hypoxia, the expression of CCR7 is elevated in both in vitro and in vivo models.•There is a correlation between HIF-1α and CCR7 in all head and neck clinical stages.•Hypoxia contributes to a metastatic phenotype in HNC by upregulating CCR7. The chemokine receptor CCR7 is expressed on lymphocy...