Quantitative assessment of placental perfusion by contrast-enhanced ultrasound in macaques and human subjects

• Published in: American journal of obstetrics and gynecology Vol. 214; no. 3; pp. 369.e1 - 369.e8
• Main Authors: Roberts, Victoria H.J., Lo, Jamie O., Salati, Jennifer A., Lewandowski, Katherine S., Lindner, Jonathan R., Morgan, Terry K., Frias, Antonio E.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2016
• Subjects: Algorithms; Animals; Caspase 3 - metabolism; Chorionic Villi - blood supply; Chorionic Villi - diagnostic imaging; Chorionic Villi - ultrastructure; Contrast Media - adverse effects; contrast-enhanced ultrasound imaging; Female; HSP70 Heat-Shock Proteins - metabolism; Humans; Japanese macaque; Kinetics; Macaca; Microbubbles - adverse effects; Obstetrics and Gynecology; placenta; Placental Circulation; placental perfusion; Pregnancy; Pregnancy Trimester, First - physiology; Pregnancy Trimester, Second - physiology; Pregnancy Trimester, Third - physiology; Signal Processing, Computer-Assisted; Trophoblasts - ultrastructure; Tyrosine - analogs & derivatives; Tyrosine - metabolism; Ultrasonography; contrast-enhanced ultrasound imaging; placenta; Japanese macaque; placental perfusion
• ISSN: 0002-9378; 1097-6868
• DOI: 10.1016/j.ajog.2016.01.001

The uteroplacental vascular supply is a critical determinant of placental function and fetal growth. Current methods for the in vivo assessment of placental blood flow are limited. We demonstrate the feasibility of the use of contrast-enhanced ultrasound imaging to visualize and quantify perfusion k...