Sox9 Is Essential for Outer Root Sheath Differentiation and the Formation of the Hair Stem Cell Compartment

• Published in: Current biology Vol. 15; no. 15; pp. 1340 - 1351
• Main Authors: Vidal, Valerie P.I., Chaboissier, Marie-Christine, Lützkendorf, Susanne, Cotsarelis, George, Mill, Pleasantine, Hui, Chi-Chung, Ortonne, Nicolas, Ortonne, Jean-Paul, Schedl, Andreas
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 09.08.2005
• Subjects: Alopecia - genetics; Animals; Carcinoma, Basal Cell - metabolism; GATA3 Transcription Factor - metabolism; Gene Expression Regulation, Developmental; Gene Silencing; Hair Follicle - cytology; Hair Follicle - embryology; Hair Follicle - metabolism; Hair Follicle - ultrastructure; Hedgehog Proteins; High Mobility Group Proteins - metabolism; Immunohistochemistry; In Situ Hybridization; Mice; Mice, Transgenic; Microscopy, Electron, Scanning; Signal Transduction - physiology; Skin Neoplasms - metabolism; SOX9 Transcription Factor; Stem Cells - cytology; Stem Cells - metabolism; Trans-Activators - metabolism; Transcription Factors - metabolism

Background: The mammalian hair represents an unparalleled model system to understand both developmental processes and stem cell biology. The hair follicle consists of several concentric epithelial sheaths with the outer root sheath (ORS) forming the outermost layer. Functionally, the ORS has been im...