Tumor cell intrinsic RON signaling suppresses innate immune responses in breast cancer through inhibition of IRAK4 signaling

• Published in: Cancer letters Vol. 503; pp. 75 - 90
• Main Authors: Bourn, Jennifer R., Ruiz-Torres, Sasha J., Hunt, Brian G., Benight, Nancy M., Waltz, Susan E.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 10.04.2021; Elsevier Limited
• Subjects: Animals; Breast cancer; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; CD8 antigen; Cell growth; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cytokines; Cytotoxicity; Female; Gene Expression Regulation, Neoplastic; Humans; Immunity, Innate; Immunotherapy; Innate immunity; Interferon; Interleukin-1 Receptor-Associated Kinases - metabolism; IRAK4 regulation; Kinases; Laboratories; Lymphocytes T; Macrophages; MCF-7 Cells; Metastases; Metastasis; Mice; Molecular modelling; Natural killer cells; Neoplasm Transplantation; Phenotypes; Receptor Protein-Tyrosine Kinases - genetics; Receptor Protein-Tyrosine Kinases - metabolism; Receptor tyrosine kinases; Rodents; Ron protein; Signal Transduction; Tumor cells; Tumor Microenvironment; Tumors; Type I IFN signaling; United States > US; Type I IFN signaling; Breast cancer; Tumor microenvironment; Receptor tyrosine kinases; IRAK4 regulation

Increasing evidence suggests that cancer cells require both alterations in intrinsic cellular processes and the tumor microenvironment for tumor establishment, growth, and progression to metastatic disease. Despite this, knowledge of tumor-cell intrinsic molecular mechanisms controlling both tumor c...