Conducting polymers, dual neurotrophins and pulsed electrical stimulation — Dramatic effects on neurite outgrowth

• Published in: Journal of controlled release Vol. 141; no. 2; pp. 161 - 167
• Main Authors: Thompson, Brianna C., Richardson, Rachael T., Moulton, Simon E., Evans, Alison J., O'Leary, Stephen, Clark, Graeme M., Wallace, Gordon G.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier B.V 25.01.2010; Elsevier
• Subjects: Animals; Animals, Newborn; Biological and medical sciences; Brain-derived neurotrophic factor; Brain-Derived Neurotrophic Factor - chemistry; Brain-Derived Neurotrophic Factor - pharmacology; Cell Survival; Cochlear Nerve - drug effects; Cochlear Nerve - growth & development; Drug Carriers; Drug Combinations; Drug Synergism; Electric Conductivity; Electric Stimulation; Electrical stimulation; General pharmacology; Kinetics; Medical sciences; Neural engineering; Neurites - drug effects; Neurotrophin 3 - chemistry; Neurotrophin 3 - pharmacology; Neurotrophin-3; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Polymers - chemistry; Polypyrrole; Pyrroles - chemistry; Rats; Rats, Wistar; Solubility; Tissue Culture Techniques; Electrical stimulation; Neurotrophin-3; Brain-derived neurotrophic factor; Neural engineering; Polypyrrole; Neurotrophin; Neurotrophic factor; Neurite; Pharmaceutical technology; Polymer; Encephalon; Growth factor

In this study the synergistic effect of delivering two neurotrophins simultaneously to encourage neuron survival and neurite elongation was explored. Neurotrophin-3 (NT-3) and brain-derived neurotrophic factor (BDNF) were incorporated into polypyrrole (PPy) during electrosynthesis and the amounts in...