Norepinephrine kinetics and dynamics in septic shock and trauma patients

• Published in: British journal of anaesthesia : BJA Vol. 95; no. 6; pp. 782 - 788
• Main Authors: Beloeil, H., Mazoit, J.-X., Benhamou, D., Duranteau, J.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.12.2005; Oxford University Press; Oxford Publishing Limited (England)
• Subjects: Adult; Aged; Aged, 80 and over; Anesthesia; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Body Weight; Chromatography, High Pressure Liquid; complications; complications, septic shock; Critical Care - methods; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Male; Medical sciences; Middle Aged; Models, Biological; norepinephrine; Norepinephrine - administration & dosage; Norepinephrine - blood; pharmacokinetics; septic shock; Severity of Illness Index; Sex Factors; Shock, Septic - blood; sympathetic nervous system; sympathetic nervous system, norepinephrine; trauma patients; Vasoconstrictor Agents - administration & dosage; Vasoconstrictor Agents - blood; Wounds and Injuries - blood; pharmacokinetics; complications, septic shock; trauma patients; sympathetic nervous system, norepinephrine; Shock; American; Multicenter study; Body weight; Variability; HPLC chromatography; septic shock; pharmacokinetics; sympathetic nervous system; Anesthesia; Complication; Arterial pressure; Blood pressure; Human; Dopamine; complications; Catecholamine; Sympathetic nervous system; Trauma; Infection; Arterial blood; Distribution volume; Neurotransmitter; Informed consent; Norepinephrine; Pharmacokinetics; norepinephrine; trauma patients

There is considerable variability in the inter-patient response to norepinephrine. Pharmacokinetic studies of dopamine infusion in volunteers and in patients have also shown large variability. The purpose of this study was to define the pharmacokinetics of norepinephrine in septic shock and trauma p...