Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms - Beltra, Jean-Christophe; Manne, Sasikanth; Abdel-Hakeem, Mohamed S.; Kurachi, Makoto; Giles, Josephine R.; Chen, Zeyu; Casella, Valentina; Ngiow, Shin Foong; Khan, Omar; Huang, Yinghui Jane; Yan, Patrick; Nzingha, Kito; et al. (Immunity (Cambridge, Mass.), 2020)
Keywords: Animals; B7-H1 Antigen - genetics; B7-H1 Antigen - immunology; Biological effects; Biology; Cancer; Cancer immunotherapy; CD8; CD8 antigen; CD8-Positive T-Lymphocytes - cytology; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - metabolism; Cell cycle; Cells, Cultured; chronic infection; Developmental biology; Epigenesis, Genetic - genetics; Epigenesis, Genetic - immunology; Epigenetics; Exhaustion; Hepatocyte nuclear factor 1; Hepatocyte Nuclear Factor 1-alpha - genetics; Hepatocyte Nuclear Factor 1-alpha - immunology; Homeodomain Proteins - genetics; Homeodomain Proteins - immunology; Humans; Immunotherapy; Immunotherapy - methods; Infections; Lymphocytes; Lymphocytes T; Mice, Inbred C57BL; Neoplasms - genetics; Neoplasms - immunology; Neoplasms - therapy; PD-1 blockade; PD-L1 protein; Population; T cell exhaustion lineage; T cell receptors; T-bet; T-Box Domain Proteins - genetics; T-Box Domain Proteins - immunology; T-Lymphocyte Subsets - immunology; T-Lymphocyte Subsets - metabolism; TCF1; Tox; Transcription; Transcription, Genetic - genetics; Transcription, Genetic - immunology; Tumors; Viral infections; T cell exhaustion lineage; chronic infection; CD8; cancer immunotherapy; exhaustion; PD-1 blockade; Tox; TCF1; T-bet; epigenetics