Mapping the Ca2+ induced structural change in calreticulin

• Published in: Journal of proteomics Vol. 142; pp. 138 - 148
• Main Authors: Boelt, Sanne Grundvad, Norn, Christoffer, Rasmussen, Morten Ib, André, Ingemar, Čiplys, Evaldas, Slibinskas, Rimantas, Houen, Gunnar, Højrup, Peter
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 16.06.2016
• Subjects: bioinformatics; Biologi; Biological Sciences; BS d; BS3 d0; BS3 d4; calcium; Calreticulin; Chemical cross-linking; crosslinking; endoplasmic reticulum; homeostasis; Mass spectrometry; MassAI software; Natural Sciences; Naturvetenskap; Protein structure; reticulin; Rosetta modelling; Chemical cross-linking; Rosetta modelling; Calreticulin; BS3 d0; BS3 d4; Mass spectrometry; Protein structure; MassAI software

Calreticulin is a highly conserved multifunctional protein implicated in many different biological systems and has therefore been the subject of intensive research. It is primarily present in the endoplasmatic reticulum where its main functions are to regulate Ca2+ homeostasis, act as a chaperone an...