Increased susceptibility of aged rats to haemorrhage and intravascular hypercoagulation following endotoxin administered in a generalized Shwartzman regime

• Published in: Journal of comparative pathology Vol. 105; no. 3; pp. 323 - 330
• Main Authors: Carthew, P., Dorman, B.M., Edwards, R.E.
• Format: Journal Article
• Language: English
• Published: London Elsevier Ltd 01.10.1991; Elsevier; Published by Elsevier Ltd
• Subjects: Aging - physiology; Animals; Bacteriology; Biological and medical sciences; Depression, Chemical; Disease Susceptibility; Disseminated Intravascular Coagulation - chemically induced; Disseminated Intravascular Coagulation - pathology; Endotoxins - administration & dosage; Endotoxins - toxicity; Fibrinolysis - drug effects; Fundamental and applied biological sciences. Psychology; Hemorrhage - chemically induced; Hemorrhage - pathology; Male; Microbiology; Rats; Shwartzman Phenomenon - chemically induced; Shwartzman Phenomenon - pathology; Tranexamic Acid - pharmacology; Vertebrata; Sensitivity; Mammalia; Histopathology; Rat; Rodentia; Endotoxin

Ageing rats are known to have an increased incidence of myocardial fibrosis and dyspnoea caused by pulmonary intravascular coagulation. In order to determine whether endotoxin can be responsible for such responses in ageing rats we have exposed rats of differing ages (2 months, 16 months and 24 mont...