Tracing the Evolutionary History and Global Expansion of Candida auris Using Population Genomic Analyses

• Published in: mBio Vol. 11; no. 2; pp. e03364 - 19
• Main Authors: Chow, Nancy A., Muñoz, José F., Gade, Lalitha, Berkow, Elizabeth L., Li, Xiao, Welsh, Rory M., Forsberg, Kaitlin, Lockhart, Shawn R., Adam, Rodney, Alanio, Alexandre, Alastruey-Izquierdo, Ana, Althawadi, Sahar, Araúz, Ana Belén, Ben-Ami, Ronen, Bharat, Amrita, Calvo, Belinda, Desnos-Ollivier, Marie, Escandón, Patricia, Gardam, Dianne, Gunturu, Revathi, Heath, Christopher H., Kurzai, Oliver, Martin, Ronny, Litvintseva, Anastasia P., Cuomo, Christina A.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 28.04.2020
• Subjects: Antifungal Agents; Antifungal Agents - pharmacology; antifungal resistance; Azoles; Azoles - pharmacology; Biological Evolution; Candida; Candida - classification; Candida - drug effects; Candida - genetics; Candida - isolation & purification; Candida auris; Candidiasis, Invasive; Candidiasis, Invasive - drug therapy; Candidiasis, Invasive - epidemiology; Drug Resistance, Fungal; Drug Resistance, Fungal - genetics; Echinocandins; Echinocandins - pharmacology; Ecological and Evolutionary Science; emerging species; Fluconazole; Fluconazole - pharmacology; Genes, Fungal; Genetics, Population; Genetics, Population - methods; genome analysis; Genome, Fungal; Humans; Life Sciences; Metagenomics; Microbiology and Parasitology; Molecular Epidemiology; Mutation; Mycology; Phylogeny; Phylogeography; population genetics; Whole Genome Sequencing; Candida auris; population genetics; emerging species; genome analysis; antifungal resistance

In less than a decade, C. auris has emerged in health care settings worldwide; this species is capable of colonizing skin and causing outbreaks of invasive candidiasis. In contrast to other Candida species, C. auris is unique in its ability to spread via nosocomial transmission and its high rates of...