Human eosinophils constitutively express nuclear factor of activated T cells p and c

• Published in: Journal of allergy and clinical immunology Vol. 107; no. 1; pp. 143 - 152
• Main Authors: Seminario, Maria-Cristina, Guo, Jia, Bochner, Bruce S., Beck, Lisa A., Georas, Steve N.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.01.2001; Elsevier
• Subjects: Allergic diseases; Binding Sites; Biological and medical sciences; DNA-Binding Proteins - genetics; Eosinophils - chemistry; Gene Expression Regulation; General aspects; Humans; Immunopathology; Interleukin-4 - pharmacology; Interleukin-5 - pharmacology; Medical sciences; NF-AT protein; NFATC Transcription Factors; Nuclear Proteins - metabolism; RNA, Messenger - metabolism; Th2 Cells - secretion; Transcription Factors - genetics; Translocation, Genetic - drug effects; Human; Immunopathology; Allergy; Cell culture; Pathogenesis; Cytokine; Granulocyte; Eosinophil; Polymerase chain reaction; Interleukin 4; T-Lymphocyte; Immunoblotting assay; Molecular biology; Transcription factor; Nuclear protein

Background: Eosinophils are now known to produce a variety of proinflammatory cytokines, although the molecular factors that regulate their production are poorly understood. The expression of almost all of the cytokines produced by eosinophils, including the proallergic cytokine IL-4, is now known t...