Hyperoside Alleviates Helicobacter pylori-Induced Gastric Epithelial Cell Injury by Regulating Nrf2/HO-1 Signaling

• Published in: Polish journal of microbiology Vol. 74; no. 1; pp. 60 - 70
• Main Authors: Wang, Yanfen, Liu, Yuxue, Zheng, Xiuhua
• Format: Journal Article
• Language: English
• Published: Poland Sciendo 01.03.2025; De Gruyter Poland
• Subjects: Anti-inflammatory agents; Apoptosis; Apoptosis - drug effects; Assaying; Cell activation; Cell injury; Cell Line; Cell Survival - drug effects; Cell viability; Cholecystokinin; Chronic infection; Cytotoxicity; Enzyme-linked immunosorbent assay; Epithelial cells; Epithelial Cells - drug effects; Epithelial Cells - metabolism; Epithelial Cells - microbiology; Epithelium; Flavonols; Flow cytometry; Gastric cancer; Gastric mucosa; Gastric Mucosa - drug effects; Gastric Mucosa - microbiology; Gastritis; Glycosides; Helicobacter Infections - drug therapy; Helicobacter Infections - microbiology; Helicobacter pylori; Helicobacter pylori - drug effects; Heme Oxygenase-1 - genetics; Heme Oxygenase-1 - metabolism; human gastric epithelial cells; Humans; Hyperoside; Immunofluorescence; Inflammation; Injuries; NF-E2-Related Factor 2 - genetics; NF-E2-Related Factor 2 - metabolism; NQO1 protein; Original Paper; Oxidative stress; Oxidative Stress - drug effects; Peptic ulcers; Quercetin - analogs & derivatives; Quercetin - pharmacology; Signal Transduction - drug effects; Staining; Western blotting; Helicobacter pylori; inflammation; human gastric epithelial cells; Hyperoside; apoptosis; gastritis; oxidative stress

Infection with is the major causative factor of chronic gastritis, peptic ulcer, gastric cancer, and other diseases. Gastric mucosal epithelial injury characterized by abnormal apoptosis, oxidative stress, and inflammation is a crucial mechanism of infection. Hyperoside (HYP) is a flavonol glycoside...