WNT6 is a novel target gene of caveolin-1 promoting chemoresistance to epirubicin in human gastric cancer cells

• Published in: Oncogene Vol. 32; no. 3; pp. 375 - 387
• Main Authors: Yuan, G, Regel, I, Lian, F, Friedrich, T, Hitkova, I, Hofheinz, R D, Ströbel, P, Langer, R, Keller, G, Röcken, C, Zimmermann, W, Schmid, R M, Ebert, M P A, Burgermeister, E
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 17.01.2013; Nature Publishing Group
• Subjects: 5-Fluorouracil; 631/67/1059/2326; 631/67/1059/99; 631/92/609; 692/699/67/1504/1829; Adult; Aged; Aged, 80 and over; Animal models; Animals; Anthracycline; Antineoplastic Agents - pharmacology; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism; Cancer; Cancer therapies; catenin; Caveolae; Caveolin 1 - metabolism; caveolin-1; Cell Biology; Cell death; Cell Line, Tumor; Chemoresistance; Chemotherapy; Cisplatin; Conserved Sequence; Doxorubicin; Drug resistance; Drug Resistance, Neoplasm - genetics; Drug therapy; Embryogenesis; Epirubicin; Epirubicin - pharmacology; Female; Gastric cancer; Gene expression; Gene Expression Regulation, Neoplastic - drug effects; Genetic aspects; Glycoproteins; Guanylate cyclase; Health aspects; Human Genetics; Humans; Integration; Internal Medicine; Male; Medicine; Medicine & Public Health; Membrane proteins; Mice; Middle Aged; Molecular modelling; Mouse mammary tumor virus; Oncology; original-article; Physiological aspects; Plasma membranes; Promoter Regions, Genetic - genetics; Promoters; scaffolds; Signal Transduction - drug effects; Stomach cancer; Stomach Neoplasms - genetics; Stomach Neoplasms - metabolism; Stomach Neoplasms - pathology; Transcription Factor 4; Transcription Factors - metabolism; Tumors; Wnt protein; Wnt Proteins - genetics; Germany; epirubicin; stomach; gastric cancer; WNT; caveolin

Resistance to chemotherapy is a major obstacle for curative treatment of human gastric cancer (GC). However, the underlying molecular mechanisms are largely unknown. Wingless-type MMTV integration site family members (WNTs) are secreted glycoproteins involved in embryogenesis and, on inappropriate e...