Subject specific effects of hyperpnea but not hypocapnia on airway conductance

We investigated the effects of hypocapnia in normal subjects on airway tone while controlling airway cooling and drying. We hypothesized that airway tone is positively related to the degree of hypocapnia. Participants (8; 2 women) underwent 3 protocols consisting of 20min of hyperpnea (breathing fre...

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Published inRespiratory physiology & neurobiology Vol. 177; no. 2; pp. 127 - 132
Main Authors Steinback, Craig D., Whitelaw, William A., Poulin, Marc J.
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier B.V 31.07.2011
Elsevier
Subjects
Adult
Biological and medical sciences
Female
Fundamental and applied biological sciences. Psychology
Humans
Hypercapnia - physiopathology
Hyperpnea
Hyperventilation
Hypocapnia
Hypocapnia - physiopathology
Male
Medical Education
Pulmonary conductance
Pulmonary resistance
Pulmonary Ventilation - physiology
Pulmonary/Respiratory
Respiratory Function Tests
Respiratory Mechanics - physiology
Vertebrates: respiratory system
Pulmonary resistance
Hyperpnea
Hyperventilation
Hypocapnia
Pulmonary conductance
Human
Respiratory tract
Vertebrata
Mammalia
Lung
Carbon dioxide
Respiratory system
Online AccessGet full text
ISSN1569-9048
1878-1519
1878-1519
DOI10.1016/j.resp.2011.03.022

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Abstract We investigated the effects of hypocapnia in normal subjects on airway tone while controlling airway cooling and drying. We hypothesized that airway tone is positively related to the degree of hypocapnia. Participants (8; 2 women) underwent 3 protocols consisting of 20min of hyperpnea (breathing frequency=20 breathsmin−1; tidal volume=2.5L) and 10min recovery. End-tidal PCO2 was maintained at +1Torr above rest (ISO; 37.9±1.2Torr), 8Torr below resting values (H-8; 29.2±1.7Torr) or 15Torr below resting values (H-15; 23.2±2.9Torr). Breath-by-breath lung conductance (GL) was calculated from flow, volume, and esophageal pressure. GL responses to hyperpnea varied widely across subjects. However, individual responses during ISO correlated highly with responses during H-8 (r=0.976, p<0.001) and H-15 (r=0.952, p<0.001), with the magnitude of change inversely related to basal GL (r=−0.555, p=0.006). Thus, inter-subject variation in GL was due to hyperpnea, with no detectable effect of hypocapnia.
AbstractList Abstract We investigated the effects of hypocapnia in normal subjects on airway tone while controlling airway cooling and drying. We hypothesized that airway tone is positively related to the degree of hypocapnia. Participants (8; 2 women) underwent 3 protocols consisting of 20 min of hyperpnea (breathing frequency = 20 breaths min−1 ; tidal volume = 2.5 L) and 10 min recovery. End-tidal P C O 2 was maintained at +1 Torr above rest (ISO; 37.9 ± 1.2 Torr), 8 Torr below resting values (H-8; 29.2 ± 1.7 Torr) or 15 Torr below resting values (H-15; 23.2 ± 2.9 Torr). Breath-by-breath lung conductance ( GL ) was calculated from flow, volume, and esophageal pressure. GL responses to hyperpnea varied widely across subjects. However, individual responses during ISO correlated highly with responses during H-8 ( r = 0.976, p < 0.001) and H-15 ( r = 0.952, p < 0.001), with the magnitude of change inversely related to basal GL ( r = −0.555, p = 0.006). Thus, inter-subject variation in GL was due to hyperpnea, with no detectable effect of hypocapnia.
We investigated the effects of hypocapnia in normal subjects on airway tone while controlling airway cooling and drying. We hypothesized that airway tone is positively related to the degree of hypocapnia. Participants (8; 2 women) underwent 3 protocols consisting of 20 min of hyperpnea (breathing frequency = 20 breaths min-1; tidal volume = 2.5 L) and 10 min recovery. End-tidal PCO2 was maintained at +1 Torr above rest (ISO; 37.9 ± 1.2 Torr), 8 Torr below resting values (H-8; 29.2 ± 1.7 Torr) or 15 Torr below resting values (H-15; 23.2 ± 2.9 Torr). Breath-by-breath lung conductance (GL) was calculated from flow, volume, and esophageal pressure. GL responses to hyperpnea varied widely across subjects. However, individual responses during ISO correlated highly with responses during H-8 (r = 0.976, p < 0.001) and H-15 (r = 0.952, p < 0.001), with the magnitude of change inversely related to basal GL (r = -0.555, p = 0.006). Thus, inter-subject variation in GL was due to hyperpnea, with no detectable effect of hypocapnia.We investigated the effects of hypocapnia in normal subjects on airway tone while controlling airway cooling and drying. We hypothesized that airway tone is positively related to the degree of hypocapnia. Participants (8; 2 women) underwent 3 protocols consisting of 20 min of hyperpnea (breathing frequency = 20 breaths min-1; tidal volume = 2.5 L) and 10 min recovery. End-tidal PCO2 was maintained at +1 Torr above rest (ISO; 37.9 ± 1.2 Torr), 8 Torr below resting values (H-8; 29.2 ± 1.7 Torr) or 15 Torr below resting values (H-15; 23.2 ± 2.9 Torr). Breath-by-breath lung conductance (GL) was calculated from flow, volume, and esophageal pressure. GL responses to hyperpnea varied widely across subjects. However, individual responses during ISO correlated highly with responses during H-8 (r = 0.976, p < 0.001) and H-15 (r = 0.952, p < 0.001), with the magnitude of change inversely related to basal GL (r = -0.555, p = 0.006). Thus, inter-subject variation in GL was due to hyperpnea, with no detectable effect of hypocapnia.
We investigated the effects of hypocapnia in normal subjects on airway tone while controlling airway cooling and drying. We hypothesized that airway tone is positively related to the degree of hypocapnia. Participants (8; 2 women) underwent 3 protocols consisting of 20min of hyperpnea (breathing frequency=20 breathsmin−1; tidal volume=2.5L) and 10min recovery. End-tidal PCO2 was maintained at +1Torr above rest (ISO; 37.9±1.2Torr), 8Torr below resting values (H-8; 29.2±1.7Torr) or 15Torr below resting values (H-15; 23.2±2.9Torr). Breath-by-breath lung conductance (GL) was calculated from flow, volume, and esophageal pressure. GL responses to hyperpnea varied widely across subjects. However, individual responses during ISO correlated highly with responses during H-8 (r=0.976, p<0.001) and H-15 (r=0.952, p<0.001), with the magnitude of change inversely related to basal GL (r=−0.555, p=0.006). Thus, inter-subject variation in GL was due to hyperpnea, with no detectable effect of hypocapnia.
We investigated the effects of hypocapnia in normal subjects on airway tone while controlling airway cooling and drying. We hypothesized that airway tone is positively related to the degree of hypocapnia. Participants (8; 2 women) underwent 3 protocols consisting of 20 min of hyperpnea (breathing frequency = 20 breaths min-1; tidal volume = 2.5 L) and 10 min recovery. End-tidal PCO2 was maintained at +1 Torr above rest (ISO; 37.9 ± 1.2 Torr), 8 Torr below resting values (H-8; 29.2 ± 1.7 Torr) or 15 Torr below resting values (H-15; 23.2 ± 2.9 Torr). Breath-by-breath lung conductance (GL) was calculated from flow, volume, and esophageal pressure. GL responses to hyperpnea varied widely across subjects. However, individual responses during ISO correlated highly with responses during H-8 (r = 0.976, p < 0.001) and H-15 (r = 0.952, p < 0.001), with the magnitude of change inversely related to basal GL (r = -0.555, p = 0.006). Thus, inter-subject variation in GL was due to hyperpnea, with no detectable effect of hypocapnia.
Author Steinback, Craig D.
Poulin, Marc J.
Whitelaw, William A.
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Issue 2
Keywords Pulmonary resistance
Hyperpnea
Hyperventilation
Hypocapnia
Pulmonary conductance
Human
Respiratory tract
Vertebrata
Mammalia
Lung
Carbon dioxide
Respiratory system
Language English
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Snippet We investigated the effects of hypocapnia in normal subjects on airway tone while controlling airway cooling and drying. We hypothesized that airway tone is...
Abstract We investigated the effects of hypocapnia in normal subjects on airway tone while controlling airway cooling and drying. We hypothesized that airway...
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SubjectTerms Adult
Biological and medical sciences
Female
Fundamental and applied biological sciences. Psychology
Humans
Hypercapnia - physiopathology
Hyperpnea
Hyperventilation
Hypocapnia
Hypocapnia - physiopathology
Male
Medical Education
Pulmonary conductance
Pulmonary resistance
Pulmonary Ventilation - physiology
Pulmonary/Respiratory
Respiratory Function Tests
Respiratory Mechanics - physiology
Vertebrates: respiratory system
Title Subject specific effects of hyperpnea but not hypocapnia on airway conductance
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https://dx.doi.org/10.1016/j.resp.2011.03.022
https://www.ncbi.nlm.nih.gov/pubmed/21457801
https://www.proquest.com/docview/868995352
Volume 177
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