Cysteine String Protein Regulates G Protein Modulation of N-Type Calcium Channels

• Published in: Neuron (Cambridge, Mass.) Vol. 28; no. 1; pp. 195 - 204
• Main Authors: Magga, Johanna M., Jarvis, Scott E., Arnot, Michelle I., Zamponi, Gerald W., Braun, Janice E.A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2000
• Subjects: Adenosine Triphosphate - metabolism; Animals; Calcium Channel Blockers - pharmacology; Calcium Channels, N-Type - drug effects; Calcium Channels, N-Type - metabolism; Cell Line; Cross-Linking Reagents - pharmacology; cysteine string proteins; GTP-Binding Proteins - genetics; GTP-Binding Proteins - metabolism; GTP-Binding Proteins - pharmacology; Hippocampus - chemistry; Hippocampus - metabolism; HSP40 Heat-Shock Proteins; Humans; Immunoblotting; In Vitro Techniques; Ion Transport - drug effects; Membrane Proteins - drug effects; Membrane Proteins - metabolism; Models, Molecular; Patch-Clamp Techniques; Potassium Chloride - pharmacology; Protein Binding - drug effects; Protein Subunits; Rats

Cysteine string proteins (CSPs) are secretory vesicle proteins bearing a “J domain” and a palmitoylated cysteine-rich “string” region that are critical for neurotransmitter release. The precise role of CSP in neurotransmission is controversial. Here, we demonstrate a novel interaction between CSP, r...