Impact of resistance training on the autophagy-inflammation-apoptosis crosstalk in elderly subjects

• Published in: Aging (Albany, NY.) Vol. 9; no. 2; pp. 408 - 418
• Main Authors: Mejías-Peña, Yubisay, Estébanez, Brisamar, Rodriguez-Miguelez, Paula, Fernandez-Gonzalo, Rodrigo, Almar, Mar, de Paz, José A., González-Gallego, Javier, Cuevas, María J.
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 02.02.2017
• Subjects: Aged; Apoptosis - physiology; Autophagy - physiology; Autophagy-Related Protein 12 - metabolism; Autophagy-Related Proteins - metabolism; Beclin-1 - metabolism; Female; Humans; Inflammasomes - metabolism; Inflammation - metabolism; Leukocytes, Mononuclear - metabolism; Lysosomal-Associated Membrane Protein 2 - metabolism; Male; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism; Research Paper; Resistance Training; apoptosis; autophagy; resistance exercise; elderly; inflammasome

Aging is associated with a decline in autophagy and a state of low-grade inflammation which further affects apoptosis and autophagy. Importantly, these alterations could reverse with regular physical activity. This study assessed the effects of a resistance exercise training program on autophagy, NL...