Meta-analysis of the impact of surgical margins on local recurrence in women with early-stage invasive breast cancer treated with breast-conserving therapy

• Published in: European journal of cancer (1990) Vol. 46; no. 18; pp. 3219 - 3232
• Main Authors: Houssami, Nehmat, Macaskill, Petra, Marinovich, M. Luke, Dixon, J. Michael, Irwig, Les, Brennan, Meagan E., Solin, Lawrence J.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.12.2010; Elsevier
• Subjects: Biological and medical sciences; Breast Neoplasms - drug therapy; Breast Neoplasms - pathology; Breast Neoplasms - radiotherapy; Breast Neoplasms - surgery; Breast-conserving therapy; Female; Hematology, Oncology and Palliative Medicine; Humans; Invasive breast cancer; Local recurrence; Lymphatic Metastasis; Mastectomy, Segmental - methods; Medical sciences; Meta-analysis; Neoplasm Recurrence, Local - etiology; Pharmacology. Drug treatments; Radiation therapy; Randomized Controlled Trials as Topic; Surgical margins; Surgical oncology; Tumors; Invasive breast cancer; Breast-conserving therapy; Local recurrence; Surgical margins; Radiation therapy; Surgical oncology; Meta-analysis; Relapse; Breast disease; Early stage; Metaanalysis; Cancerology; Surgery; Adult; Female; Surgical margin; Invasive cancer; Mammary gland; Woman; Human; Breast cancer; Malignant tumor; Radiotherapy; Mammary gland diseases; Treatment; Cancer

There is no consensus on what constitutes adequate negative margins in breast-conserving therapy (BCT). We review the evidence on surgical margins in BCT for early-stage invasive breast cancer. Meta-analysis of studies reporting local recurrence (LR) relative to quantified final microscopic margin s...