P2 domain profiles and shedding dynamics in prospectively monitored norovirus outbreaks

• Published in: Journal of clinical virology Vol. 56; no. 4; pp. 286 - 292
• Main Authors: Sukhrie, Faizel H.A., Teunis, Peter, Vennema, Harry, Bogerman, Jolanda, van Marm, Sebastian, Beersma, Matthias F.C. Thijs, Koopmans, Marion
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2013
• Subjects: Adult; Aged; Aged, 80 and over; Allergy and Immunology; Amino Acid Sequence; Caliciviridae Infections - epidemiology; Caliciviridae Infections - virology; Disease Outbreaks; Feces - virology; Follow-Up Studies; Genetic Variation; Health Personnel; Humans; Infectious Disease; Middle Aged; Molecular Sequence Data; Mutation; Norovirus; Norovirus - genetics; Norovirus - pathogenicity; Norovirus - physiology; Norovirus transmission; P2 domain; Phylogeny; Prospective Studies; Real-Time Polymerase Chain Reaction; RNA, Viral - genetics; Sequence Analysis, Protein; Shedding; Time Factors; Viral Proteins - analysis; Virus Replication; Virus Shedding; Shedding; OB; NoV; Norovirus transmission; EMC; P2 domain; HCW; university hospital; norovirus; health care workers; outbreaks

Norovirus P2 domain is commonly used to extrapolate transmission within an outbreak (OB) setting. The current definition is that transmission among cases is considered to be proven when no sequence variation is found. Previous studies have shown a high mutation rate and errors during replication of...