Review of 54 patients with complete DiGeorge anomaly enrolled in protocols for thymus transplantation: outcome of 44 consecutive transplants

• Published in: Blood Vol. 109; no. 10; pp. 4539 - 4547
• Main Authors: Markert, M. Louise, Devlin, Blythe H., Alexieff, Marilyn J., Li, Jie, McCarthy, Elizabeth A., Gupton, Stephanie E., Chinn, Ivan K., Hale, Laura P., Kepler, Thomas B., He, Min, Sarzotti, Marcella, Skinner, Michael A., Rice, Henry E., Hoehner, Jeffrey C.
• Format: Journal Article
• Language: English
• Published: Washington, DC Elsevier Inc 15.05.2007; The Americain Society of Hematology; American Society of Hematology
• Series: Transplantation
• Subjects: B-Lymphocytes - physiology; Biological and medical sciences; Biopsy; DiGeorge Syndrome - mortality; DiGeorge Syndrome - surgery; Female; Hematologic and hematopoietic diseases; Humans; Infant, Newborn; Infections - epidemiology; Leukocyte Count; Male; Medical sciences; Retrospective Studies; Survival Analysis; T-Lymphocytes - cytology; Thymus Gland - pathology; Thymus Gland - transplantation; Transplantation; Transplantation, Homologous - adverse effects; Transplantation, Homologous - methods; Transplantation, Homologous - mortality; Human; Immunopathology; Prognosis; Thymus gland; Treatment; Hematology; DiGeorge syndrome; Surgery; Graft; Transplantation; Review; Bibliographic review

The purpose of this study was to characterize a large group of infants with complete DiGeorge anomaly and to evaluate the ability of thymus transplantation to reconstitute immune function in these infants. DiGeorge anomaly is characterized by varying defects of the heart, thymus, and parathyroid gla...