Evolution of the CYP2ABFGST gene cluster in rat, and a fine-scale comparison among rodent and primate species

• Published in: Genetica Vol. 133; no. 2; pp. 215 - 226
• Main Authors: Hu, Shengyong, Wang, Haoyi, Knisely, Alyssa A, Reddy, Shanti, Kovacevic, David, Liu, Zhi, Hoffman, Susan M. G
• Format: Journal Article
• Language: English
• Published: Dordrecht Dordrecht : Springer Netherlands 01.06.2008; Springer Netherlands; Springer Nature B.V
• Subjects: Animal Genetics and Genomics; Animals; Aryl Hydrocarbon Hydroxylases - genetics; Biomedical and Life Sciences; Chromosomal rearrangement; Chromosome 1; CYP2ABFGST cluster; cytochrome P-450; Cytochrome P-450 CYP2B1 - genetics; Cytochrome P-450 Enzyme System - genetics; Cytochrome P450 Family 2; Evolution, Molecular; Evolutionary Biology; Gene evolution; Gene family; Human Genetics; Humans; Life Sciences; Mammals; Mice; Microbial Genetics and Genomics; Multigene Family; Phylogeny; Plant Genetics and Genomics; Primates; Primates - genetics; Rats; Rodentia - genetics; Rodents; Steroid Hydroxylases - genetics; cluster; Gene evolution; Gene family; Chromosomal rearrangement; Cytochrome P450

The evolution of gene families can be best understood by studying the modern organization and functions of family members, and by comparing parallel families in different species. In this study, the CYP2ABFGST gene cluster has been characterized in rat and compared to the syntenic clusters in mouse...