Cloning and heterologous expression of P450Lent4B11, a novel bacterial P450 gene, for hydroxylation of an antifungal agent sordaricin - Ueno, Motoi; Kobayashi, Motoo; Fujie, Akihiko; Shibata, Takashi (Journal of antibiotics, 2020)
Keywords: 38; 38/22; 38/23; 45/29; 631/1647/2234; 631/326/252; 82/80; Actinomycetales; Actinomycetales - genetics; Antifungal Agents; Antifungal Agents - pharmacology; Bacteriology; Biomedical and Life Sciences; Bioorganic Chemistry; Biotransformation; Biotransformation - genetics; Cloning; Cloning, Molecular; Cloning, Molecular - methods; Cytochrome; Cytochrome P-450 Enzyme System; Cytochrome P-450 Enzyme System - genetics; Diterpenes; Diterpenes - pharmacology; Fungi; Fungi - drug effects; Genes, Bacterial; Genes, Bacterial - genetics; Hydroxylation; Hydroxylation - genetics; Indenes; Indenes - pharmacology; Life Sciences; Medicinal Chemistry; Metyrapone; Metyrapone - pharmacology; Microbiology; Organic Chemistry; Oxidation-Reduction; Oxidation-Reduction - drug effects; Protein synthesis