Establishment and characterization of a new highly metastatic human osteosarcoma cell line

• Published in: Clinical & experimental metastasis Vol. 26; no. 7; pp. 599 - 610
• Main Authors: Su, Yuxi, Luo, Xiaoji, He, Bai-Cheng, Wang, Yi, Chen, Liang, Zuo, Guo-Wei, Liu, Bo, Bi, Yang, Huang, Jiayi, Zhu, Gao-Hui, He, Yun, Kang, Quan, Luo, Jinyong, Shen, Jikun, Chen, Jin, Jin, Xianqing, Haydon, Rex C, He, Tong-Chuan, Luu, Hue H
• Format: Journal Article
• Language: English
• Published: Dordrecht Dordrecht : Springer Netherlands 01.10.2009; Springer Netherlands; Springer Nature B.V
• Subjects: Animals; Base Sequence; Biomedical and Life Sciences; Biomedicine; Blotting, Western; Bone Neoplasms - genetics; Bone Neoplasms - pathology; Cancer Research; Cell Adhesion; Cell Line, Tumor; DNA Primers; Gene Expression Regulation, Neoplastic; Hematology; Humans; Male; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Oncology; Osteoblastoma - genetics; Osteoblastoma - pathology; Research Paper; Reverse Transcriptase Polymerase Chain Reaction; Surgical Oncology; Animal model; Matrix metalloproteinase; Metastasis; Osteosarcoma; Ezrin

Osteosarcoma is the most common primary malignancy of bone in children and young adults. There is a paucity of tumorigenic and highly metastatic human osteosarcoma cell lines that have not been further transformed by exogenous means. Here we establish and characterize a highly metastatic human osteo...