Minocycline and Ethylenediaminetetraacetate for the Prevention of Recurrent Vascular Catheter Infections

Three patients with recurrent vascular catheter-related bacteremia were successfully treated by allowing a solution of minocycline and ethylenediaminetetraacetate (EDTA) to dwell in the lumen of the indwelling catheter or by coating polyurethane catheters with minocycline/EDTA and flushing the lumen...

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Published inClinical infectious diseases Vol. 25; no. 1; pp. 149 - 151
Main Authors Raad, Issam, Buzaid, Antonio, Rhyne, Janelle, Hachem, Ray, Darouiche, Rabih, Safar, Hossam, Albitar, Maher, Sherertz, Robert J.
Format Journal Article
LanguageEnglish
Published Chicago, IL The University of Chicago Press 01.07.1997
University of Chicago Press
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Abstract Three patients with recurrent vascular catheter-related bacteremia were successfully treated by allowing a solution of minocycline and ethylenediaminetetraacetate (EDTA) to dwell in the lumen of the indwelling catheter or by coating polyurethane catheters with minocycline/EDTA and flushing the lumen daily with the same solution. In vitro and in vivo experiments showed that minocycline/ EDTA may have broad-spectrum antimicrobial activity, may have optimal anticoagulant activity, and may be highly efficacious in preventing catheter colonization.
AbstractList Abstract only
Three patients with recurrent vascular catheter-related bacteremia were successfully treated by allowing a solution of minocycline and ethylenediaminetetraacetate (EDTA) to dwell in the lumen of the indwelling catheter or by coating polyurethane catheters with minocycline/EDTA and flushing the lumen daily with the same solution. In vitro and in vivo experiments showed that minocycline/ EDTA may have broad-spectrum antimicrobial activity, may have optimal anticoagulant activity, and may be highly efficacious in preventing catheter colonization.
Author Darouiche, Rabih
Safar, Hossam
Albitar, Maher
Sherertz, Robert J.
Buzaid, Antonio
Hachem, Ray
Rhyne, Janelle
Raad, Issam
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  givenname: Antonio
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  fullname: Buzaid, Antonio
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  surname: Rhyne
  fullname: Rhyne, Janelle
  organization: Department of Medical Specialties, Section of Infectious Diseases, the Department of Melanoma/Sarcoma, and the Division of Laboratory Medicine, The University of Texas M. D. Anderson Cancer Center, and the Infectious Disease Section, Baylor College of Medicine and Veterans Affairs Medical Center, Houston, Texas, Winston-Salem, North Carolina
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  fullname: Darouiche, Rabih
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  fullname: Safar, Hossam
  organization: Department of Medical Specialties, Section of Infectious Diseases, the Department of Melanoma/Sarcoma, and the Division of Laboratory Medicine, The University of Texas M. D. Anderson Cancer Center, and the Infectious Disease Section, Baylor College of Medicine and Veterans Affairs Medical Center, Houston, Texas, Winston-Salem, North Carolina
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Issue 1
Keywords Human
Drug combination
Relapse
Intravenous administration
Tetracycline derivatives
Catheter
EDTA
Bacteremia
Infection
Case study
Prevention
Chemotherapy
Bacteriosis
Minocycline
Complication
Antibacterial agent
Resuscitation
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Notes Reprints or correspondence: Dr. Issam Raad, Section of Infectious Diseases, The University of Texas M. D. Anderson Cancer Center, Box 47, 1515 Holcombe Boulevard, Houston, Texas 77030.
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Snippet Three patients with recurrent vascular catheter-related bacteremia were successfully treated by allowing a solution of minocycline and...
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SubjectTerms Adult
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Anti-Bacterial Agents - therapeutic use
Antibiotics
Anticoagulants
Anticoagulants - therapeutic use
Antimicrobials
Bacteremia
Bacteremia - etiology
Bacteremia - prevention & control
Biological and medical sciences
Cancer
Catheterization, Central Venous - adverse effects
Catheters
Central venous catheterization
Coatings
Drug Therapy, Combination
Edetic Acid - therapeutic use
Emergency and intensive care: techniques, logistics
Enterobacter - isolation & purification
Enterobacteriaceae Infections - etiology
Enterobacteriaceae Infections - prevention & control
Fatal Outcome
Female
Humans
Infections
Infectious diseases
Intensive care medicine
Male
Medical sciences
Middle Aged
Minocycline - therapeutic use
Perfusions. Catheterizations. Hyperbaric oxygenotherapy
Recurrence
Staphylococcal Infections - etiology
Staphylococcal Infections - prevention & control
Title Minocycline and Ethylenediaminetetraacetate for the Prevention of Recurrent Vascular Catheter Infections
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