Minocycline and Ethylenediaminetetraacetate for the Prevention of Recurrent Vascular Catheter Infections

• Published in: Clinical infectious diseases Vol. 25; no. 1; pp. 149 - 151
• Main Authors: Raad, Issam, Buzaid, Antonio, Rhyne, Janelle, Hachem, Ray, Darouiche, Rabih, Safar, Hossam, Albitar, Maher, Sherertz, Robert J.
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University of Chicago Press 01.07.1997; University of Chicago Press
• Subjects: Adult; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Anti-Bacterial Agents - therapeutic use; Antibiotics; Anticoagulants; Anticoagulants - therapeutic use; Antimicrobials; Bacteremia; Bacteremia - etiology; Bacteremia - prevention & control; Biological and medical sciences; Cancer; Catheterization, Central Venous - adverse effects; Catheters; Central venous catheterization; Coatings; Drug Therapy, Combination; Edetic Acid - therapeutic use; Emergency and intensive care: techniques, logistics; Enterobacter - isolation & purification; Enterobacteriaceae Infections - etiology; Enterobacteriaceae Infections - prevention & control; Fatal Outcome; Female; Humans; Infections; Infectious diseases; Intensive care medicine; Male; Medical sciences; Middle Aged; Minocycline - therapeutic use; Perfusions. Catheterizations. Hyperbaric oxygenotherapy; Recurrence; Staphylococcal Infections - etiology; Staphylococcal Infections - prevention & control; Human; Drug combination; Relapse; Intravenous administration; Tetracycline derivatives; Catheter; EDTA; Bacteremia; Infection; Case study; Prevention; Chemotherapy; Bacteriosis; Minocycline; Complication; Antibacterial agent; Resuscitation
• ISSN: 1058-4838; 1537-6591
• DOI: 10.1086/514518

Three patients with recurrent vascular catheter-related bacteremia were successfully treated by allowing a solution of minocycline and ethylenediaminetetraacetate (EDTA) to dwell in the lumen of the indwelling catheter or by coating polyurethane catheters with minocycline/EDTA and flushing the lumen daily with the same solution. In vitro and in vivo experiments showed that minocycline/ EDTA may have broad-spectrum antimicrobial activity, may have optimal anticoagulant activity, and may be highly efficacious in preventing catheter colonization.