Antimalarial Activity of Some Kenyan Medicinal Plants

This paper describes the in vitro antimalarial activity of eight species of plants popularly used traditionally to treat malaria in Kenya. Organic and aqueous extracts from different parts of the plants were tested. Generally, a stronger antimalarial activity was observed in the organic extracts. Th...

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Published inPharmaceutical biology Vol. 37; no. 5; pp. 329 - 334
Main Authors Oketch-Rabah, H.A, Dossaji, S.F., Mberu, E.K.
Format Journal Article
LanguageEnglish
Published Lisse Informa UK Ltd 1999
Taylor & Francis
Swets & Zeitlinger
Subjects
Biological and medical sciences
General pharmacology
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Kenya
Africa
Protozoa
Antimalarial
Plasmodium falciparum
Apicomplexa
Folk medicine
Pharmacognosy
Parasiticid
Plant origin
In vitro
Biological activity
Medicinal plant
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Abstract This paper describes the in vitro antimalarial activity of eight species of plants popularly used traditionally to treat malaria in Kenya. Organic and aqueous extracts from different parts of the plants were tested. Generally, a stronger antimalarial activity was observed in the organic extracts. The most active extracts were of Vernonia brachycalyx O. Hoffm. Schreber. (Compositae) leaves which showed an IC 50 of 6.6 µg/ml for methylene chloride: ethyl acetate (1:1) extracts, while the aqueous and more polar methanolic extracts gave IC 50 values of 29.6 and 30 µg/ml, respectively. The findings of this study support the use of this plant as a traditional remedy for malaria. The rest of the plants tested gave IC 50 values between 30-100 µg/ml.
AbstractList This paper describes the in vitro antimalarial activity of eight species of plants popularly used traditionally to treat malaria in Kenya. Organic and aqueous extracts from different parts of the plants were tested. Generally, a stronger antimalarial activity was observed in the organic extracts. The most active extracts were of Vernonia brachycalyx O. Hoffm. Schreber. (Compositae) leaves which showed an IC 50 of 6.6 µg/ml for methylene chloride: ethyl acetate (1:1) extracts, while the aqueous and more polar methanolic extracts gave IC 50 values of 29.6 and 30 µg/ml, respectively. The findings of this study support the use of this plant as a traditional remedy for malaria. The rest of the plants tested gave IC 50 values between 30-100 µg/ml.
Author Mberu, E.K.
Dossaji, S.F.
Oketch-Rabah, H.A
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Cites_doi 10.1055/s-2006-957514
10.1128/AAC.38.7.1470
10.1016/0031-9422(95)00522-9
10.1126/science.3887571
10.4269/ajtmh.1987.37.445
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ContentType Journal Article
Copyright 1999 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1999
2000 INIST-CNRS
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Issue 5
Keywords Protozoa
Antimalarial
Plasmodium falciparum
Apicomplexa
Folk medicine
Pharmacognosy
Parasiticid
Plant origin
In vitro
Biological activity
Medicinal plant
Language English
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Desjardin RE (CIT0004) 1979; 16
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SubjectTerms Biological and medical sciences
General pharmacology
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Title Antimalarial Activity of Some Kenyan Medicinal Plants
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