Ubiquitous plasticizer, Di-(2-ethylhexyl) phthalate enhances existing inflammatory profile in monocytes of children with autism

• Published in: Toxicology (Amsterdam) Vol. 446; p. 152597
• Main Authors: Nadeem, Ahmed, Ahmad, Sheikh F., Al-Harbi, Naif O., AL-Ayadhi, Laila Y., Attia, Sabry M., Alasmari, Abdullah F, As Sobeai, Homood M, Bakheet, Saleh A.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 15.12.2020
• Subjects: Autism; Autism Spectrum Disorder - metabolism; Autism Spectrum Disorder - pathology; Cells, Cultured; Child; children; Chronic disease; cosmetics; Cross-Sectional Studies; DEHP; dermal exposure; Diethylhexyl Phthalate - toxicity; Emergency; Environmental Exposure - adverse effects; Female; floors; Humans; Inflammation; Inflammation Mediators - metabolism; inhalation exposure; interleukin-1beta; interleukin-6; Male; metabolites; Monocytes; Monocytes - drug effects; Monocytes - metabolism; Monocytes - pathology; oral exposure; pathogenesis; phthalates; Plasticizer; plasticizers; Plasticizers - toxicity; toys; tumor necrosis factor-alpha; Autism; Monocytes; Inflammation; Plasticizer; Chronic disease; DEHP

[Display omitted] •DEHP upregulates NFkB/STAT3 expression in monocytes of ASD children.•DEHP upregulates IL-6, TNF-α, IL-1β in monocytes of ASD children.•Inhibition of NFkB and STAT3 attenuates DEHP-induced inflammation in monocytes of ASD. Genetic as well as environmental factors are believed to pl...