Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant - Atwell, Shane; Brouillette, Christie G.; Conners, Kris; Emtage, Spencer; Gheyi, Tarun; Guggino, William B.; Hendle, Jorg; Hunt, John F.; Lewis, Hal A.; Lu, Frances; Protasevich, Irina I.; Rodgers, Logan A.; et al. (Protein engineering, design and selection, 2010)
Keywords: ABC transporter; BASIC BIOLOGICAL SCIENCES; Binding Sites - genetics; CFTR; Cloning, Molecular; Crystallization; Cystic Fibrosis Transmembrane Conductance Regulator - chemistry; Cystic Fibrosis Transmembrane Conductance Regulator - isolation & purification; Dimerization; DNA Primers - genetics; FIBROSIS; GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE; Humans; Models, Molecular; MUTANTS; Mutation - genetics; MUTATIONS; NBD1; NUCLEOTIDES; Protein Conformation; Protein Structure, Tertiary - genetics; PROTEINS; regulatory insert; REMOVAL; RESIDUES; RESOLUTION; ΔF508; regulatory insert; NBD1; ABC transporter; CFTR; ΔF508