Is there a relationship between baseline and treatment-associated changes in [3H]-IMI platelet binding and clinical response in major depression?

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 14; no. 1; pp. 47 - 53
• Main Authors: Tollefson, Gary D., Heiligenstein, John H., Tollefson, Sherrie L., Birkett, Martin A., Knight, David L., Nemeroff, Charles B.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.01.1996; Nature Publishing
• Subjects: 3H-IMI binding; Adolescent; Adult; Aged; Biological and medical sciences; Blood Platelets - metabolism; Depression; Depressive Disorder - blood; Depressive Disorder - drug therapy; Double-Blind Method; Female; Fluoxetine; Fluoxetine - therapeutic use; Humans; Imipramine - metabolism; Imipramine - therapeutic use; Kinetics; Male; Medical sciences; Middle Aged; Neuropharmacology; Pharmacology. Drug treatments; Platelet; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Radioligand Assay; Response prediction; Time Factors; Tricyclic; Depression; Platelet; Tricyclic; 3H-IMI binding; Fluoxetine; Response prediction; Human; Mood disorder; Serotonin; Psychotropic; Treatment efficiency; Prediction; Biological marker; Binding site; Tricyclic compound; Reuptake inhibitor; Chemotherapy; Biological fixation; Double blind study; Antidepressant agent

A peripheral model for the central 5-HT neuron is the characterization of platelet imipramine binding. We studied an outpatient major depressive cohort who fulfilled Research Diagnostic Criteria for agitation. After a 1-week placebo lead-in, subjects were blindly randomized to either imipramine (IMI...