Patterns and Causes of Signed Linkage Disequilibria in Flies and Plants

• Published in: Molecular biology and evolution Vol. 38; no. 10; pp. 4310 - 4321
• Main Authors: Sandler, George, Wright, Stephen I, Agrawal, Aneil F
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.10.2021
• Subjects: Analysis; Animals; Capsella - genetics; Discoveries; Drosophila; Drosophila melanogaster - genetics; Epistasis; Fruit flies; Genes; Genome, Plant; Genomes; Genomics; Linkage Disequilibrium; Missense mutation; Mutation; Plant genetics; Hill–Robertson interference; epistasis; admixture; linkage disequilibrium

Most empirical studies of linkage disequilibrium (LD) study its magnitude, ignoring its sign. Here, we examine patterns of signed LD in two population genomic data sets, one from Capsella grandiflora and one from Drosophila melanogaster. We consider how processes such as drift, admixture, Hill–Rober...